A5078099107- Trace Elements in Health
- Heavy Metal Exposure and Toxicity
- Glaucoma and retinal disorders
- Retinal Development and Disorders
- Retinal Diseases and Treatments
- Aluminum toxicity and tolerance in plants and animals
- Receptor Mechanisms and Signaling
- Retinal Imaging and Analysis
- Photoreceptor and optogenetics research
- Iron Metabolism and Disorders
- Peripheral Artery Disease Management
- Axon Guidance and Neuronal Signaling
- Cerebrovascular and genetic disorders
- Pharmacology and Obesity Treatment
- Folate and B Vitamins Research
- Vascular Procedures and Complications
- Obsessive-Compulsive Spectrum Disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- Aortic aneurysm repair treatments
- Transcranial Magnetic Stimulation Studies
- Neuroscience and Neuropharmacology Research
- Reproductive Biology and Fertility
- Tuberculosis Research and Epidemiology
- Parathyroid Disorders and Treatments
- Glutathione Transferases and Polymorphisms
Post Graduate Institute of Medical Education and Research
2005-2024
Indian Institute of Science Bangalore
2024
All India Institute of Medical Sciences Bhopal
2019
All India Institute of Medical Sciences Raipur
2019
All India Institute of Medical Sciences
2019
Baylor College of Medicine
2016-2018
University of California, San Diego
2017
Houston Methodist
2017
John Hunter Hospital
2016
University of Utah
2011-2014
Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in elderly. Wet AMD includes typical choroidal neovascularization (CNV) and polypoidal vasculopathy (PCV). The etiology pathogenesis CNV PCV are not well understood. Genome-wide association studies have linked a multifunctional serine protease, HTRA1, to AMD. However, precise role HTRA1 remains elusive. By transgenically expressing human mouse retinal pigment epithelium, we showed that increased induced...
Angiogenesis improves perfusion to the ischemic tissue after acute vascular obstruction. in pathophysiological settings reactivates signaling pathways involved developmental angiogenesis. We showed previously that AIBP (apolipoprotein A-I [apoA-I]-binding protein)-regulated cholesterol efflux endothelial cells controls zebra fish embryonic angiogenesis.This study is determine whether loss of affects angiogenesis mice during development and under pathological conditions explore underlying...
Ovarian cancer (OC) is the third most common gynecological and alone has an emergence rate of approximately 308,069 cases worldwide (2020) with dire survival rates. To put it into perspective, mortality OC three times higher than that breast predicted to only increase significantly by 2040. The primary reasons for such a high are physical symptoms detectable during advanced phase disease when resistance chemotherapies around 80% patients do indeed respond chemotherapy initially, show poor...
Significance Despite in vitro evidence, it remains unclear whether the rod visual pigment rhodopsin exists as dimers vivo. With a unique mouse line that expresses blue cone opsin transgenically rods, we showed that, absence of chromophore, transgenic can mature and target to outer segment if only is present help along (i.e., forming heterodimers endoplasmic reticulum). Furthermore, have confirmed key interaction domain for dimerization show again vivo, maturation targeting becomes defective...
Polypoidal choroidal vasculopathy (PCV) is characterized by a branching vascular network (BVN) of choroid that terminates in polypoidal dilations. We have previously reported the generation first PCV model transgenically expressing human HTRA1 (hHTRA1(+)), multifunctional serine protease, mouse RPE. The purpose this study was to perform comprehensive examination phenotypes (e.g., lesion type and distribution) hHTRA1(+) mice variety vivo imaging techniques.We generated improved with more...
Abstract Elevated intracranial pressure (ICP) can result in multiple neurologic sequelae including vision loss. Inducible models of ICP elevation are lacking model organisms, which limits our understanding the mechanism by increased impacts visual system. We adapted a mouse for sustained and tested hypothesis that elevated optic nerve retinal ganglion cells (RGCs). was maintained 2 weeks, resulted anatomic changes consistent with human disease papilledema, loss physiologic cupping,...
Indocyanine Green Angiography (or ICGA) is a technique performed by ophthalmologists to diagnose abnormalities of the choroidal and retinal vasculature various eye diseases such as age-related macular degeneration (AMD). ICGA especially useful image posterior due its capability penetrating through pigmented layer with infrared spectrum. time course can be divided into early, middle, late phases. The three phases provide valuable information on pathology problems. Although time-course...
The use of covered tibial stents extends beyond the treatment atherosclerotic disease. Tibial artery pseudoaneurysms have traditionally been managed with open surgery; however, endovascular option is an emerging treatment.This report describes management iatrogenic anterior pseudoaneurysm using a stent.This case highlights stent for exclusion, vascular control, and to minimize dissection in patient multiple previous surgeries.
Background: A number of polymerase chain reaction (PCR) based techniques like single-strand conformational polymorphism (SSCP), amplification refractory mutation system (ARMS)-PCR, semi-nested PCR and dinucleotide-repeat marker analysis have been used in the diagnosis asymptomatic Wilson disease (WD) patients carrier status WD families. In present study, we explore utility combination with restriction fragment length (RFLP) genetic WD.