A5040735702- Primate Behavior and Ecology
- Child and Animal Learning Development
- Animal Vocal Communication and Behavior
- Retinal Development and Disorders
- Human-Animal Interaction Studies
- Animal Behavior and Reproduction
- Photoreceptor and optogenetics research
- Memory and Neural Mechanisms
- Neuroscience and Neural Engineering
- Face Recognition and Perception
- Neuroendocrine regulation and behavior
- Evolutionary Psychology and Human Behavior
- Olfactory and Sensory Function Studies
- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Action Observation and Synchronization
- Cell Image Analysis Techniques
- Evolutionary Game Theory and Cooperation
- Visual perception and processing mechanisms
- Psychology of Moral and Emotional Judgment
- Early Childhood Education and Development
- Wildlife Ecology and Conservation
- Advanced Fluorescence Microscopy Techniques
- Animal Behavior and Welfare Studies
- Advanced Electron Microscopy Techniques and Applications
University of Utah
2013-2024
Kyoto University
2014-2023
University of Nebraska Medical Center
2023
University of Stirling
2006-2021
Eye Institute of Utah
2008-2019
Google (United States)
2005-2018
Anderson University - Indiana
2005
Centre National de la Recherche Scientifique
1991-1998
Laboratoire de Psychologie et NeuroCognition
1985-1996
Université de Strasbourg
1995
Early visual defects in degenerative diseases such as retinitis pigmentosa (RP) may arise from phased remodeling of the neural retina. The authors sought to explore functional expression ionotropic (iGluR) and group 3, type 6 metabotropic (mGluR6) glutamate receptors late-stage photoreceptor degeneration.Excitation mapping with organic cations computational molecular phenotyping were used determine whether retinal neurons displayed receptor signaling rodent models degeneration a sample human...
Many primary sensory cilia exhibit unique architectures that are critical for transduction of specific stimuli. Although basic ciliogenic mechanisms well described, how complex ciliary structures generated remains unclear. Seminal work performed several decades ago provided an initial but incomplete description diverse morphologies in C. elegans. To begin to explore the generate these remarkably structures, we have taken advantage advances electron microscopy and tomography, reconstructed...
Six adult female chimpanzees were shown video scenes of repeatedly yawning or showing open–mouth facial expressions that not yawns. Two out the six females showed significantly higher frequencies in response to yawn videos; no inverse. Three infant accompanied their mothers did at all. These data are highly reminiscent contagious effects reported for humans. Contagious is thought be based on capacity empathy. provides further evidence these apes may possess advanced self–awareness and...
Abstract Increased human population growth and more conversions of natural habitat to agricultural land have resulted in greater proximity between humans nonhuman primate species. Consequent increases resource competition including crop‐raiding are a by‐product both resources becoming less available the nutritional benefits cultivated foods known primates. Chimpanzees at Bossou Republic Guinea, West Africa, consume 17 different types that grown extensively throughout their small, fragmented...
Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in elderly. Wet AMD includes typical choroidal neovascularization (CNV) and polypoidal vasculopathy (PCV). The etiology pathogenesis CNV PCV are not well understood. Genome-wide association studies have linked a multifunctional serine protease, HTRA1, to AMD. However, precise role HTRA1 remains elusive. By transgenically expressing human mouse retinal pigment epithelium, we showed that increased induced...
Circuitry mapping of metazoan neural systems is difficult because canonical regions (regions containing one or more copies all components) are large, regional borders uncertain, neuronal diversity high, and potential network topologies so numerous that only anatomical ground truth can resolve them. Complete a specific requires synaptic resolution, region coverage, robust classification. Though transmission electron microscopy (TEM) remains the optimal tool for mapping, process building large...
The mammalian AII retinal amacrine cell is a narrow-field, multistratified glycinergic neuron best known for its role in collecting scotopic signals from rod bipolar cells and distributing them to ON OFF cone pathways crossover network via combination of inhibitory synapses heterocellular AII::ON gap junctions. Long considered simple cell, full connectomics analysis shows that possess most complex interaction repertoire any vertebrate neuron, contacting at least 28 different classes,...
The sharing of wild plant foods is infrequent in chimpanzees, but chimpanzee communities that engage hunting, meat frequently used as a 'social tool' for nurturing alliances and social bonds. Here we report the only recorded example regular by unrelated, non-provisioned contexts which these behaviours occur. From direct observations, adult chimpanzees at Bossou (Republic Guinea, West Africa) very rarely transferred foods. In contrast, they shared cultivated much more (58 out 59 food events)....
Abstract We have examined the effects of vibrissal damage on structure VB murine thalamus. The findings are: (1) barreloid (Van der Loos, '76) pattern can be recognized in normal adult mouse On basis size, population neurons bimodal, larger neurons–presumed to thalamocortical relay cells (TCR's)–outnumbering smaller thalamic interneurons–by 3:1. (2) Damage vibrissa Row‐C PND‐1 (postnatal day‐1) results an altered cytoarchitectonic barreloids contralateral VB, which is qualitatively similar...
Abstract Retinitis pigmentosa (RP) is an inherited blinding disease characterized by progressive loss of retinal photoreceptors. There are numerous rodent models degeneration, but most poor platforms for interventions that will translate into clinical practice. The rabbit possesses a number desirable qualities model including large eye and existing substantial knowledge base in circuitry, anatomy, ophthalmology. We have analyzed remodeling, reprogramming expressing rhodopsin proline 347 to...