A5075983019- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Mitochondrial Function and Pathology
- Genetic Neurodegenerative Diseases
- Glaucoma and retinal disorders
- Autoimmune Neurological Disorders and Treatments
- DNA Repair Mechanisms
- Retinal and Optic Conditions
- Endoplasmic Reticulum Stress and Disease
Children's Hospital of Philadelphia
2022-2025
University of Pennsylvania
2024
Baylor College of Medicine
2017-2022
Abstract Objective Most individuals with Friedreich ataxia (FRDA) have homozygous GAA triplet repeat expansions in the FXN gene, correlating a typical phenotype of and cardiomyopathy. A minority are compound heterozygotes carrying expansion on one allele mutation other. The study aim was to examine phenotypic variation among heterozygotes. Methods Data mutations were obtained from Ataxia Clinical Outcome Measures Study (FA‐COMS). We compared clinical features single‐site FA‐COMS cohort 51...
Many patients of choroidal neovascularization (CNV) are unresponsive to the current anti-VEGF treatment. The mechanisms for resistance poorly understood. We explore unique property apolipoprotein A-I (apoA-I) binding protein (AIBP) that enhances cholesterol efflux from endothelial cells and macrophages thereby limit angiogenesis inflammation tackle in CNV. show laser-induced CNV mice with increased age showed treatment, which correlates lipid accumulation macrophages. combination AIBP/apoA-I...
Purpose: Anti-VEGF resistance represents a major unmet clinical need in the management of choroidal neovascularization (CNV). We have previously reported that combination AIBP, apoA-I, and an anti-VEGF antibody overcomes laser-induced CNV old mice prevention experiments. The purpose this work is to conduct more clinically relevant study assess efficacy aflibercept treatment experimental at different time points after laser photocoagulation. Methods: To understand pathobiology resistance, we...