A5100634267- RNA modifications and cancer
- Pancreatitis Pathology and Treatment
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Neonatal Respiratory Health Research
- Inhalation and Respiratory Drug Delivery
- Phytoestrogen effects and research
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- RNA Research and Splicing
- Fungal Biology and Applications
- Regional Economic and Spatial Analysis
- Biological Activity of Diterpenoids and Biflavonoids
- Near-Field Optical Microscopy
- E-commerce and Technology Innovations
- FOXO transcription factor regulation
- Cultural Differences and Values
- Effects and risks of endocrine disrupting chemicals
- Autopsy Techniques and Outcomes
- Technology Adoption and User Behaviour
- Histone Deacetylase Inhibitors Research
- Asthma and respiratory diseases
- Cancer therapeutics and mechanisms
- Wine Industry and Tourism
- Fatty Acid Research and Health
Hunan Normal University
2012-2025
Hunan Provincial People's Hospital
2022-2024
Hunan Institute of Microbiology
2024
Hunan Provincial Center for Disease Control and Prevention
2023
First Affiliated Hospital of GuangXi Medical University
2022
Guangxi Medical University
2022
Tobacco Research Institute
2017
Chinese PLA General Hospital
2015
Analysis Group (United States)
2014
University of Michigan
2014
Although the relationship between stressors and thriving at work has been established, linkage them is still in early stages of theory development. This study proposed a two-path model, based on Lepine's stressors-performance to analyze effects work. Two complementary mediating paths were proposed, i.e., affective strain (positive affect) motivation (self-efficacy), which explained using events expectancy theory, respectively. Based empirical data from 233 employees, results show that...
Abstract Background Recent studies showed that macrophages co-cultured with ovarian cancer stem-like cells (OCSLCs) induced SKOV3 cell stemness via IL-8/STAT3 signaling. Genistein (GEN) demonstrates chemopreventive activity in inflammation-associated cancers. The present study aimed to examine whether and if GEN inhibits the of OVCA-3R by co-culture THP-1 SKOV3-derived OCSLCs. Methods was treated or without different concentrations (10, 20, 40 μmol/L) for 24 h. Depletion addition IL-8 Co-CM...
// Qian Mei 1,2,* , Meixia Chen Xuechun Lu Xiang Li 1,2 Feng Duan 3 Maoqiang Wang Guangbin Luo 1,4,* and Weidong Han * 1 Department of Molecular Biology, School Life Sciences, Chinese PLA General Hospital, Beijing, P. R. China 2 Bio-therapeutic, Interventional Radiology, 4 Genetics Genome Case Comprehensive Cancer Center, Western Reserve University Medicine, Cleveland, Ohio, USA These authors have contributed equally to this work Correspondence to: Han, email: Luo, Keywords : decitabine,...
Abstract Colorectal cancer ( CRC ) exhibiting MSI (microsatellite instability) represents a well‐defined subtype characterized by deficient mismatch repair pathway and typical clinico‐pathological features. Our objective was to identify the entire miRNome its molecular pathological roles in CRCs . We profiled miRNA expression compared it with MSS counterparts. Microarray qRT‐PCR analysis identified eight miRNAs that could distinguish status of MiR ‐484 most significantly decreased ,...
Abstract Background Manganese superoxide dismutase (MnSOD) upregulating FoxM1 have previously been demonstrated promoting lung cancer stemness. Isovitexin exhibits antitumor activities in various cancers. This study aimed to assess whether isovitexin inhibits hepatic carcinoma stem-like cells (HCSLCs) features via regulating MnSOD and expression. Methods Second-generation spheres from the cell lines, respectively, were used as HCSLCs. Protein amounts of MnSOD, stemness-associated markers...
Abstract Background CSLCs(Cancer stem cell-like cells), which are central to tumorigenesis, intrinsically influenced by epigenetic modifications. This study aimed elucidate the underlying mechanism involving DNMT1/miR-152-3p/SOS1 axis in regulating self-renewal and tumor growth of LCSLCs (lung cancer stem-like cells). Materials methods Target genes miR-152-3p were predicted using TargetScan Human 8.0. Self-renewal LCSLC compared suspension-cultured non-small cell lung (NSCLC) lines H460 A549...
In 2009, the passing of Family Smoking Prevention and Tobacco Control Act facilitated establishment FDA Center for Products (CTP), gave it regulatory authority over marketing, manufacture distribution tobacco products, including those termed 'modified risk'. On 4-6 April 2016, Institute Vitro Sciences, Inc. (IIVS) convened a workshop conference entitled, Exposure Systems Dosimetry Assessment Tools Inhaled Products, to bring together stakeholders representing agencies, academia industry...
Pulmonary fibrosis is considered to be an irreversible lung injury, which can caused by paraquat (PQ) poisoning. MiRNAs have been demonstrated crucial roles in pulmonary numerous approaches including PQ induction. The purpose of this study was investigate the role and underlying mechanism miR-215 PQ-induced fibrosis.The cell animal models were established through intervention. Cell viability performed test MTT assay. Immunofluorescence assay used detect COL1A1 expression its location....
The DNA methyltransferase 1 (DNMT1)/miR-34a axis promoted carcinogenesis of various types cancers. However, no literature reported its contribution to the stemness osteosarcoma cancer stem-like cells (OSLCs). We sought determine whether DNMT1/miR-34a facilitates OSLCs. here revealed higher DNMT1 activity and expression, lower miR-34a expression with high methylation promoter, stronger OSLCs, as manifested by elevated sphere colony formation capacities; CD133, CD44, ABCG2, Bmi1, Sox2, Oct4...
Human liver cancer stem-like cells (HLCSLCs) are widely acknowledged as significant factors in the recurrence and eradication of hepatocellular carcinoma (HCC). The sustenance HLCSLCs' stemness is hypothesized to be intricately linked epigenetic process DNA methylation modification genes associated with anticancer properties. present study aimed elucidate stemness-maintaining mechanism HLCSLCs provide a novel idea for clearance HLCSLCs.
This study aims to explore the molecular mechanism of N6-methyladenosine (m6A) modification-related long noncoding RNA (lncRNA)–microRNA (miRNA)–messenger (mRNA) network in regulating autophagy and affecting occurrence development acute pancreatitis (AP). RNA-seq datasets related AP were obtained from Gene Expression Omnibus (GEO) database merged after batch effect removal. lncRNAs significantly m6A AP, namely candidate lncRNA, screened by correlation analysis differential expression...
Signal transducer and activator of transcription 3 (STAT3) is a member the family latent cytoplasmic transcriptional factors that could regulate cell proliferation, survival, development. It has been reported Twist target gene STAT3, STAT3/Twist signaling plays an important role in regulating cancer progress. Here, to explore whether 8-bromo-7-methoxychrysin (BrMC) inhibits liver stem-like (LCSLC) properties via disrupting signaling, we cultured SMMC-7721 cells vitro, evaluated effects BrMC...
To observe the clinical effect of initiating continuous blood purification (CBP) treatment at different times for patients with severe acute pancreatitis (SAP), and to explore optimal timing starting CBP SAP, so as provide evidence clinicians start treatment.
To observe the relation between expression of CTNNAL1 and airway resistance in rats with hyperresponsiveness.Thirty Wister were randomly divided into 5 groups: a normal control group, 2 d ozone attack 4 6 attack+2 dexamethasone treatment group (6 each group). The distribution was observed by situ hybridization; detected fluorescence quantitative RT-PCR; Buxco pulmonary function analysis system; relevance respiratory tract rat hyperresponsiveness analyzed.CTNNAL1 distributed bronchial...
ABSTRACT Four days after the announcement of 2014 Nobel Prize in Chemistry for “the development super‐resolved fluorescence microscopy” based on single molecule detection, Single Molecule Analysis Real‐Time (SMART) Center at University Michigan hosted a “Principles Techniques 2014” course. Through combination plenary lectures and an Open House SMART Center, course took snapshot technology with especially broad rapidly expanding range applications biomedical materials sciences. Highlighting...
To investigate the efficacy of arterial partial pressure oxygen (PaO2), procalcitonin (PCT) combined with ROX index in predicting timing tracheal intubation patients acute severe pancreatitis (SAP).A case-control study was conducted. A total 148 SAP admitted to Hunan Provincial People's Hospital from January 2019 December 2022 were selected as research objects. According whether endotracheal used after admission during hospitalization, divided into group (102 cases) and non-intubation (46...
Abstract Background Acute pancreatitis (AP) is an inflammatory disease that causes pancreatic autodigestion, and severe AP (SAP) associated with high morbidity mortality. Thus, a rapid approach reverses harmful symptoms when patients arrive at the emergency room required. Methods We investigated effect mechanism of intragastric hypothermia on using dual metabolomics strategy to detect metabolites metabolic pathways. ELISA immunohistochemistry western blotting were used measure serum amylase...