A5061274699- Monoclonal and Polyclonal Antibodies Research
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Glycosylation and Glycoproteins Research
- T-cell and Retrovirus Studies
- HIV Research and Treatment
- Diabetes and associated disorders
- Immunodeficiency and Autoimmune Disorders
- Lymphatic System and Diseases
- Immunotherapy and Immune Responses
- Advanced Biosensing Techniques and Applications
- HIV-related health complications and treatments
- Immune Response and Inflammation
- Cytomegalovirus and herpesvirus research
Scripps Research Institute
2018-2024
Semmelweis University
1999
Orszagos Kornyezetegeszsegugyi Intezet
1999
An HCV vaccine strategy displays optimized E2 cores on nanoparticles for eliciting a cross-neutralizing B cell response.
An alternate conformation is found for the major antibody target on hepatitis C virus to aid in rational vaccine design.
Significance Hepatitis C virus (HCV) infects 1–2% of the world’s population, but a vaccine to limit spreading this silent killer is unavailable. A leading strategy in design counter genetic variability HCV elicit broadly neutralizing antibodies (bnAbs) targeting conserved viral epitopes. The antigenic site 412–423 (AS412) highly and prime target. In study, structural properties murine bnAbs AS412 were determined. Using specific molecular interactions encoded antibody germline genes those...
Type 1 diabetes (T1D) is a prototypic T cell-mediated autoimmune disease. Because the islets of Langerhans are insulated from blood vessels by double basement membrane and lack detectable lymphatic drainage, interactions between endocrine circulating cells not permitted. Thus, we hypothesized that initiation progression anti-islet immunity required islet neolymphangiogenesis to allow cell access islet. Combining microscopy single approaches, timing this phenomenon in mice was situated 5 8 wk...
Abstract Antibiotic resistance threatens clinical control of bacterial infections while the genetic adaptability microbes continues to outpace small-molecule development. The combinatorial diversity antibodies offers a solution this problem. However, under normal circumstances polymeric glycans surfaces avoid adaptive recognition by not binding MHC molecules. Thus, they are T cell independent antigens and targeted only low affinity IgM responses. Glycoconjugate vaccines have been developed...
ABSTRACT Hepatitis C virus (HCV) envelope glycoproteins E1 and E2 are critical for cell entry with being the major target of neutralizing antibodies (NAbs). Here, we present a comprehensive strategy B cell-based HCV vaccine development through optimization nanoparticle display. We redesigned variable region 2 in truncated form (tVR2) on cores derived from genotypes 1a 6a, resulting improved stability antigenicity. Crystal structures three optimized human cross-genotype NAbs (AR3s) revealed...
P204 The involvement of HTLV-like retroviral elements in induction eosinohpilia various dermatoses was investigated Hungary, where exogenous HTLV infection has not yet been reported. DNA samples skin specimens and lymphocytes from 50 patients were analysed by PCR amplifying a 210 bp conserved fragments (1323-1442 bp) HTLV-1 gag. Amplicons than cloned E.Coli XLI-Blue strain. analysis have identified containing homologous (>95%) sequences to gag >70 % with lymphoreticular proliferation...