A5087180831- Craniofacial Disorders and Treatments
- Bone fractures and treatments
- Toxic Organic Pollutants Impact
- Atmospheric and Environmental Gas Dynamics
- Orthopedic Surgery and Rehabilitation
- Cleft Lip and Palate Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Trauma and Emergency Care Studies
- Hip and Femur Fractures
- Orthopedic Infections and Treatments
- Single-cell and spatial transcriptomics
- Mercury impact and mitigation studies
- Inorganic Fluorides and Related Compounds
- Petroleum Processing and Analysis
- Advanced ceramic materials synthesis
- Fluorine in Organic Chemistry
- Muscle Physiology and Disorders
- Congenital limb and hand anomalies
- Advanced materials and composites
- Air Quality and Health Impacts
- Congenital heart defects research
- Analytical Chemistry and Chromatography
- Neurogenetic and Muscular Disorders Research
- Injury Epidemiology and Prevention
- RNA regulation and disease
Shenzhen Children's Hospital
2019-2025
Zhengzhou University
2021-2025
China Medical University
2019-2024
Guangxi Medical University
2024
Sichuan University
2022-2024
West China Second University Hospital of Sichuan University
2022-2024
Shanghai Institute of Technology
2023-2024
University of Hong Kong
2022-2023
University of Hong Kong - Shenzhen Hospital
2022-2023
Chinese University of Hong Kong
2023
Parkinson's disease (PD) is a neurodegenerative disease, leading to the impairment of movement execution. PD pathogenesis has been largely investigated, either limited bulk transcriptomic levels or at certain cell types, which failed capture cellular heterogeneity and intrinsic interplays among distinct types. Here, we report application single-nucleus RNA-seq on midbrain, striatum, cerebellum α-syn-A53T mouse, well-established mouse model, matched controls, generating first single atlas for...
Neuromuscular abnormality is the leading cause of disability in adults. Understanding complex interplay between muscle structure and function crucial for effective treatment rehabilitation. However, substantial deformation muscles during movement (up to 40%) poses challenges accurate assessment. To address this, we developed a wearable structural-functional sensing patch (WSFP) that enables synchronous analysis function. The WSFP incorporates soft, stretchable electrode array...
Abstract Unfired calcium aluminate cement (CAC) bonded alumina‐spinel based plug precasts have many advantages including energy saving, shorter placement period, lower cost and good thermal shock resistance in comparison with fired purging plugs. Unfortunately, their strength was drastically decreased the range of 700°C–1000°C, which attributed to destruction hydrates network castables, structural spalling also occurred because strength. To respond these, a feasible method fabricate higher...
Abstract Purpose To explore and analyze the causes related influencing factors of pediatric fractures, provide theoretical basis for reducing incidence adverse effects fractures. Methods This study retrospectively analyzed epidemiological characteristics fractures in aged ≤18 years old who were admitted to our hospital between July 2015 February 2020. Results A total 10,486 patients included study, whom 6961 (66.38%) boys, 3525 (33.62%) girls. For fracture incidence, age group 3-6 reached...
This study produced gridded deposition estimates of polycyclic aromatic compounds (PACs), including 17 hydrocarbons (PAHs), 21 alkylated PAHs (alk-PAHs), and 5 dibenzothiophenes (DBTs), over the oil sands region Alberta, Canada surrounding communities. Gridded annual total PACs in 2011 ranged from 55 to 175 000 μg m–2 yr–1 mean median fluxes were 1700 760 yr–1, respectively. The domain-wide dry wet 600 1100 yr–1. PAHs, alk-PAHs DBTs contributed 19%, 74%, 7% deposition, 42%, 49%, 9%...
The brain of the domestic pig (Sus scrofa domesticus) has drawn considerable attention due to its high similarities that humans. However, cellular compositions (PB) remain elusive. Here we investigated single-nucleus transcriptomic profiles five regions PB (frontal lobe, parietal temporal occipital and hypothalamus) identified 21 cell subpopulations. cross-species comparison mouse hypothalamus revealed shared specific gene expression patterns at single-cell resolution. Furthermore, types...
Abstract Background In this study, to provide a theoretical basis for understanding the clinical characteristics of epiphyseal fractures in children and improving their management, we explored analyzed proportions different types evaluated causes injury epidemiological characteristics. Methods We retrospectively younger than 18 years with fresh who were admitted our hospital from July 2015 February 2020. Demographic information, mechanisms, fracture characteristics, classification surgical...
Abstract. Two speciated and spatially resolved emissions databases for polycyclic aromatic compounds (PACs) in the Athabasca oil sands region (AOSR) were developed. The first database was derived from volatile organic compound (VOC) data provided by Cumulative Environmental Management Association (CEMA) second additional collected within Joint Canada–Alberta Oil Sands Monitoring (JOSM) program. CALPUFF modelling results atmospheric hydrocarbons (PAHs), alkylated PAHs, dibenzothiophenes...
To uncover the role of satellite cells (SCs) in paravertebral muscle development and aging, we constructed a single-nucleus transcriptomic atlas mouse across seven timepoints spanning embryo (day 16.5) to old (month 24) stages. Eight cell types, including SCs, fast cells, slow were identified. An energy metabolism-related gene set, TCA CYCLE IN SENESCENCE, was enriched SCs. Forty-two skeletal disease-related genes highly expressed SCs exhibited similar expression patterns. Among them, Pdha1...
The Scottish Inflammatory Prognostic Score (SIPS), an innovative scoring system, has emerged as a promising biomarker for predicting patient outcomes following cancer therapy. This study aimed to evaluate the value of SIPS prognostic indicator hepatectomy in patients with hepatocellular carcinoma (HCC). retrospective included 693 HCC who underwent hepatectomy. Survival were compared between propensity score-matched groups. Independent factors identified through Cox regression analysis....
Abstract Background Fractures are the most common type of unintentional injury in children, with traumatic upper limb fractures accounting for approximately 80% all childhood fractures. Many epidemiological investigations children have been conducted, but development society, patterns may changed. This study aimed to analyze epidemiology and economic cost factors Chinese children. Methods We retrospectively reviewed or old hospitalized between December 1, 2015, 31, 2019, 22 tertiary...
This study developed an emission inventory for 29 elements in PM2.5 and PM2.5-10 covering area of approximately 300 by 420 km2 the Athabasca Oil Sands Region northern Alberta, Canada. Emission sources were aggregated into nine categories, which (OS) Sources emitted most, followed Non-OS Dust both fine coarse over area. The top six particulate include Si, Ca, Al, Fe, S, K (933, 442, 323, 269, 116, 103 tonnes/year, respectively), sum accounted 20.5% total emissions. five (3713, 1815, 1198,...
Abstract Congenital muscular torticollis (CMT) is a common musculoskeletal abnormality in children, which has been characterized by unclarified pathological changes the sternocleidomastoid muscle (SCM) and various hypothetical etiologies. There are 2 main etiologies for CMT literature: 1 infers that may represent sequela of an intrauterine or perinatal compartment syndrome, other regard as maldevelopment fetal SCM. To better understand etiopathogenesis CMT, we screened necks 1-day-old...
Abstract Objective Differentiating septic arthritis from transient synovitis in children is challenging. This study aimed to determine the diagnostic value for distinguishing these two conditions and develop an effective clinical prediction model based on multi-center data. Methods We retrospectively analyzed data of aged under 18 years who were hospitalized eight specialized children’s hospitals China 2013 2021. To ensure model’s reliability, we established three models. Results collected...
Developmental dysplasia of the hip (DDH) is most common deformity in pediatric orthopedics. One pathological changes DDH thickening and hypertrophy ligamentum teres. However, underlying pathogenic mechanism responsible for these remains unclear. This study represents first time that heterogeneity cell subsets abnormal teres patients with has been resolved at single-cell spatial levels by snRNA-Seq MiP-Seq. Through gene set enrichment intercellular communication network analyses, we found...
Abstract Background Fractures of hands and feet are common in children, but relevant epidemiological studies currently lacking. We aim to study the characteristics hand foot fractures growth plate injuries children provide a theoretical basis for their prevention, diagnosis, treatment. Methods retrospectively analyzed data with who were hospitalized at Shenzhen Children’s Hospital between July 2015 December 2020. Data on demographic characteristics, fracture site, treatment method, etiology...
This study introduces a novel trifluoromethylating reagent, [(bpy)Cu(O2CCF2SO2F)2], notable for not only its practical synthesis from cost-effective starting materials and scalability but also nonhygroscopic nature. The reagent demonstrates high efficiency in facilitating trifluoromethylation reactions with various halogenated hydrocarbons, yielding products good yields exhibiting broad functional group compatibility. development of [(bpy)Cu(O2CCF2SO2F)2] represents an advancement the field...
To analyze the causes, locations, associated injuries, and relevant factors of lower limb pelvic fractures in hospitalized children China to provide a theoretical basis for reducing incidence such fractures. A retrospective analysis with admitted 27 tertiary children's hospitals affiliated China's Futang Research Center Pediatric Development between December 1, 2015, 31, 2019, was conducted. Inpatient cases were analyzed following age groups: Infants (< 2 years), Preschool (2–5 School (6–11...