A5052502570- Bone fractures and treatments
- Trauma and Emergency Care Studies
- Pelvic and Acetabular Injuries
- Pregnancy and preeclampsia studies
- Reproductive System and Pregnancy
- Orthopedic Infections and Treatments
- Spine and Intervertebral Disc Pathology
- Osteoarthritis Treatment and Mechanisms
- Spinal Fractures and Fixation Techniques
- Orthopedic Surgery and Rehabilitation
- Child and Adolescent Health
- Hip and Femur Fractures
- Streptococcal Infections and Treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Pregnancy and Medication Impact
- Musculoskeletal Disorders and Rehabilitation
- Multiple Myeloma Research and Treatments
- Injury Epidemiology and Prevention
- Neonatal Respiratory Health Research
- S100 Proteins and Annexins
- Autopsy Techniques and Outcomes
- Ophthalmology and Visual Impairment Studies
- Cancer-related gene regulation
- Ion Transport and Channel Regulation
- Cancer Risks and Factors
Shenzhen Children's Hospital
2020-2024
Soochow University
2020-2023
First Affiliated Hospital of Soochow University
2020-2023
Guangdong Medical College
2023
China Medical University
2021-2022
Shandong University
2013-2017
University of Shanghai for Science and Technology
2015
Nantong Maternity and Child Health Hospital
2014-2015
Nantong University
2014-2015
Mount Desert Island Biological Laboratory
1994
By mediating the coupled movement of Na, K, and Cl ions across plasma membrane most animal cells, bumetanide-sensitive Na-K-Cl cotransporter (NKCC) plays a vital role in regulation ionic balance cell volume. The transporter is central element process vectorial salt transport secretory absorptive epithelia. A cDNA encoding cotransport protein was isolated from shark rectal gland library by screening with monoclonal antibodies to native cotransporter. 1191-residue predicted sequence has 12...
Abstract Epithelial–mesenchymal transition ( EMT ) plays an important role in the invasiveness and metastasis of gastric cancer. Therefore, identifying key molecules involved will provide new therapeutic strategy for treating patients with TIPE 1 is a newly identified member TNFAIP 8) family, its contributions to progression have not been evaluated. In this study, we found that levels were significantly reduced inversely correlated differentiation status distant primary cancer tissues. We...
Abstract Purpose To explore and analyze the causes related influencing factors of pediatric fractures, provide theoretical basis for reducing incidence adverse effects fractures. Methods This study retrospectively analyzed epidemiological characteristics fractures in aged ≤18 years old who were admitted to our hospital between July 2015 February 2020. Results A total 10,486 patients included study, whom 6961 (66.38%) boys, 3525 (33.62%) girls. For fracture incidence, age group 3-6 reached...
Objectives The aim of this study was to evaluate the clinical outcomes Wiltse approach and percutaneous pedicle screw placement under O‐arm navigation for treatment thoracolumbar fracture. Methods We enrolled a total 54 patients with neurologically intact fracture who received minimally invasive treatments between October 2014 2018 in retrospective study. Among these, 28 (22 males six females, mean age 48.6 ± 9.6 years) were treated fixation through (WPSF), another 26 (15 11 45.7 10.6...
To analyze the causes, locations, associated injuries, and relevant factors of lower limb pelvic fractures in hospitalized children China to provide a theoretical basis for reducing incidence such fractures. A retrospective analysis with admitted 27 tertiary children's hospitals affiliated China's Futang Research Center Pediatric Development between December 1, 2015, 31, 2019, was conducted. Inpatient cases were analyzed following age groups: Infants (< 2 years), Preschool (2–5 School (6–11...
A balance between bone formation by osteoblasts and resorption osteoclasts is necessary to maintain health homeostasis. As a cancer of plasma cells, multiple myeloma (MM) accompanied with rapid loss fragility fracture. Bortezomib has been used as first‐line for treating MM decades. Recently, the potential protection bortezomib on osteoporosis (OP) reported; however, specific mechanism involving bortezomib‐mediated antiosteoporotic effect undetermined. In present study, we assessed effects in...
Vascular endothelial growth factor (VEGF) activity is involved in the and stability of placenta, its signaling has been implicated development pregnancy‑induced hypertension (PIH). The present study sought to evaluate VEGF levels dendritic cell (DC) profiles patients with PIH, investigate effects expression on DC phenotypes. assessed 162 patients, 112 whom were diagnosed PIH. Serum was measured by ELISA, while myeloid (mDC; (Lin1‑HLA‑DR+CD11c+) plasmacytoid (pDC; Lin1‑HLA‑DR+CD123+) counts...
Abstract Background Fractures of hands and feet are common in children, but relevant epidemiological studies currently lacking. We aim to study the characteristics hand foot fractures growth plate injuries children provide a theoretical basis for their prevention, diagnosis, treatment. Methods retrospectively analyzed data with who were hospitalized at Shenzhen Children’s Hospital between July 2015 December 2020. Data on demographic characteristics, fracture site, treatment method, etiology...
Articular cartilage-derived progenitor cells (ACPCs) possess the properties of both chondrocytes and bone marrow mesenchymal stem (BMSCs). However, number ACPCs in articular cartilage is low, an effective culture system needed for their expansion. Basic fibroblast growth factor (bFGF) promotes expansion BMSCs, as well chondrogenic differentiation BMSCs. Therefore, aim this study was to clarify whether bFGF could be used vitro promoted construction ACPCs.We applied fibronectin adhesion method...
Objective Osteoarthritis (OA) is a severe and common degenerative disease; however, the exact pathology of OA undefined. Our study designed to investigate underlying molecular mechanism with bioinformatic tools. Design Three updated GEO datasets: GSE55235, GSE55457, GSE82107 were selected for data analyzing. R software was utilized screen confirm candidate differentially expressed genes in development OA. Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes pathway performed identify enriched...
Abstract Background Fractures of hands and feet are common in children, but relevant epidemiological studies currently lacking. We aim to study the characteristics hand foot fractures growth plate injuries children provide a theoretical basis for their prevention, diagnosis, treatment. Methods retrospectively analyzed data with who were hospitalized at Shenzhen Children's Hospital between July 2015 December 2020. Data on demographic characteristics, fracture site, treatment method, etiology...
Abstract Objectives To develop an objective method based on texture analysis MRI for diagnosis of congenital muscular torticollis (CMT). Material and methods The T1- T2-weighted imaging, Q-dixon, T1-mapping data 38 children with CMT were retrospectively analyzed. region interest (ROI) was manually drawn at the level largest cross-sectional area SCM affected side. MaZda software used to obtain features T2WI sequences ROI in healthy SCM. A radiomics diagnostic model muscle constructed using...
<title>Abstract</title> <bold>Purpose:</bold> To analyze the causes, locations, associated injuries, and relevant factors of lower limb pelvic fractures in Chinese children to provide a theoretical basis for reducing incidence such fractures. <bold>Methods:</bold> A retrospective analysis with admitted 27 tertiary children's hospitals affiliated China's Futang Research Center Pediatric Development between December 1, 2015, 31, 2019, was conducted. Inpatient cases were analyzed following age...
<title>Abstract</title> Purpose Transient synovitis of the hip (TSH) is most common cause acute limp among children. The clinical characteristics and time onset TSH in children must be fully understood. As such, this study analyzed demographic characteristics, preceding factors, positive rates laboratory values, association between number onsets climate with to provide clues a deeper understanding etiology TSH. Methods A single-center retrospective analysis information, values from...
<title>Abstract</title> Purpose This study analyzes the demographic information, concurrent infectious diseases, treatment methods, and hospitalization costs for children with transient synovitis of hip (TSH) in China to provide a scientific basis its early diagnosis, decisions, preventive measures. Methods We retrospectively analyzed data TSH who were hospitalized across 32 pediatric tertiary hospitals affiliated China’s Futang Research Center Pediatric Development between December 1, 2015,...
BackgroundThe objective of this study was to compare the outcomes and complications patients who underwent either calcaneal skeletal traction (CST) or elastic intramedullary nails (EIN) procedure.MethodsWe retrospectively reviewed data EIN CST surgery for tibia shaft fracture at our center from 2013 2018. The patient demographics, characteristics, radiographic information, length hospital stay, medical expenses were recorded. All clinically followed-up until they started walk least 6 months....
Abstract Background Unintentional injury is one of the top three causes death for infants. However, epidemiological studies skeletal trauma and skull fractures in infants younger than 1 year were poorly understood China. Therefore, our study aimed to examine accidental emergency attendance under year. It also tried determine prevalence severity accident types Methods A retrospective analysis was performed on demographic characteristics with who visited Shenzhen Children’s Hospital from...
Progressive addition lens (PAL) is designed for those who suffer from myopia and presbyopia to have a clear vision far distance nearby distance. Additionally there are many people that also astigmatism need be corrected. The cylinder power can't simply added the diopter of PAL directly, because needs changed smoothly. A methods has been proposed in this article solve problem, freeform surface height without cylindrical correction calculated separately. both two heights were together, then...
Objective: To investigate the clinical significance and pathogenesis of heterogeneous nuclear ribonucleoprotein U (hnRNP U) in acute myeloid leukemia (AML) . Methods: The expression hnRNP U, an RNA binding protein, patients with AML healthy controls was compared based on Gene Expression Profiling Interactive Analysis database data center. Beat Dataset (n=158) downloaded from cBioPortal database. level divided into high-expression group (n=89) low-expression (n=69) , patients' characteristics...