A5101851922- Immune Response and Inflammation
- interferon and immune responses
- Inflammasome and immune disorders
- Cell death mechanisms and regulation
- Phagocytosis and Immune Regulation
- Ubiquitin and proteasome pathways
- Atherosclerosis and Cardiovascular Diseases
- Cancer-related gene regulation
- Cancer-related Molecular Pathways
- RNA Interference and Gene Delivery
- Microtubule and mitosis dynamics
- Hedgehog Signaling Pathway Studies
- Tuberculosis Research and Epidemiology
- 14-3-3 protein interactions
- Hepatitis B Virus Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- NF-κB Signaling Pathways
- Pediatric Hepatobiliary Diseases and Treatments
- Angiogenesis and VEGF in Cancer
- Prostate Cancer Treatment and Research
- Immune Cell Function and Interaction
- Telomeres, Telomerase, and Senescence
- ATP Synthase and ATPases Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Erythrocyte Function and Pathophysiology
Shandong University
2007-2022
The First People’s Hospital of Lianyungang
2019
Nanjing Medical University
2019
Zhejiang Provincial People's Hospital
2017
Zhejiang University
2017
Lishui Central Hospital
2017
Qilu Hospital of Shandong University
2013
International Drug Development
2013
Genoscience Pharma (France)
2013
Atherosclerosis has been widely recognized as an inflammatory disease of the arterial wall in which macrophages play a major role. Yet, how macrophage-mediated pathology is regulated during atherosclerosis poorly understood. TNF-α-induced protein 8-like 2 (TIPE2, also known TNFAIP8L2) highly expressed resting and can negatively regulate inflammation through inhibiting immune receptor signaling. We report this article that TIPE2 plays crucial atheroprotective role likely by regulating...
Both commensal bacteria and infiltrating inflammatory cells play essential roles in the pathogenesis of bowel disease. The molecular mechanisms whereby these pathogenic factors are regulated during disease not fully understood. We report this article that a member TNF-α-induced protein 8 (TNFAIP8) family called TIPE2 (TNFAIP8-like 2) plays crucial role regulating dissemination cell function experimental colitis induced by dextran sodium sulfate (DSS). Following DSS treatment, TIPE2-deficient...
Abstract Epithelial–mesenchymal transition ( EMT ) plays an important role in the invasiveness and metastasis of gastric cancer. Therefore, identifying key molecules involved will provide new therapeutic strategy for treating patients with TIPE 1 is a newly identified member TNFAIP 8) family, its contributions to progression have not been evaluated. In this study, we found that levels were significantly reduced inversely correlated differentiation status distant primary cancer tissues. We...
Tumor necrosis factor (TNF)-alpha-induced protein 8 (TNFAIP8 or TIPE) is a recently identified considered to be associated with carcinogenesis. To investigate its expression pattern in pancreatic cancer patients and analyse correlation clinicopathological significance the levels of epithelial growth receptor (EGFR), immunohistochemistry was performed detect TNFAIP8 EGFR proteins cancers, pancreatitis tissues, healthy controls. The results showed stronger staining tissues compared normal...
BACKGROUND: NIMA-related kinase 2 (NEK2), a serine/threonine kinase, is located in the centrosome and member of cell cycle regulation related protein (CCRK) family. Aberrant expression NEK2 linked with carcinogenesis progression various tumors. OBJECTIVE: To investigate level its relationship clinicopathological factors hepatocellular carcinoma (HCC). METHODS: Immunohistochemistry was used to measure 310 patients' specimen tissues 197 adjacent normal liver HCC cases, subsequent prognostic...
Acute respiratory distress syndrome (ARDS) is a devastating condition of acute inflammatory lung injury and causes high morbidity mortality. Therefore, investigations on the effective biomarkers will be significant for understanding ARDS. In our research, gene expression profiles 27 samples from ARDS patients (n = 18) healthy controls 9) were analyzed eight co-expression modules identified by constructing weighted network. The correlation analysis with phenotypes showed that genes in yellow...
Abstract Aging is a natural and progressive process characterized by an increased frequency of age-related diseases such as cancer. But its mechanism unclear. TNFAIP8L2 (Tipe2) important negative regulator for homeostasis through inhibiting TLR TCR signaling. Our work reveals that Tipe2 might have dual function regulating senescence. One side, the overexpression in CRC cells could induce typical senescent phenotype, especially exposure to oxidative stress. inhibits telomerase activity c-Myc...
Anoikis resistance is the prerequisite of cancer cells metastasis. Elucidation mechanism anoikis remains a significant challenge. We reported here model to mimic resistant process hepatoma in vitro. Experimental results indicated cell aggregation could mediate BEL7402 cells. Further investigation these aggregations biological properties changed greatly after lost their anchorage. Aggregation forming be separated into three distinct phases according characteristics, comprising premature...
Colorectal cancer (CRC) is the third leading cause of in United States, and inflammatory bowel disease patients have an increased risk developing CRC due to chronic intestinal inflammation with it being death 10% 15% patients. TIPE2 (TNF-alpha-induced protein 8-like 2) a phospholipid transporter that highly expressed immune cells important regulator cell function.The azoxymethane/dextran sulfate sodium murine model colitis-associated colon (CAC) was employed Tipe2 -/- wild-type mice, along...