A5101742438- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Pediatric Hepatobiliary Diseases and Treatments
- Cancer-related gene regulation
- Gallbladder and Bile Duct Disorders
- Ferroptosis and cancer prognosis
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Kruppel-like factors research
- Pancreatitis Pathology and Treatment
- Gastrointestinal Tumor Research and Treatment
- Epigenetics and DNA Methylation
- TGF-β signaling in diseases
- Liver Diseases and Immunity
- Sarcoma Diagnosis and Treatment
- Neuroscience and Neuropharmacology Research
- Nanoplatforms for cancer theranostics
- Cellular Mechanics and Interactions
- Medicinal Plant Pharmacodynamics Research
- Lipid metabolism and disorders
- Pluripotent Stem Cells Research
- Genetic Syndromes and Imprinting
- Receptor Mechanisms and Signaling
Shandong Provincial Hospital
2013-2024
Shandong First Medical University
2024
Shandong University
2013-2021
Hepatocellular carcinoma (HCC) is the most common primary malignancy of liver in adults worldwide. Several studies have demonstrated that long noncoding RNAs (lncRNAs) are involved development various types cancer, including HCC. These findings prompted us to examine detectability lncRNAs blood samples from patients with In this study, we explored expression levels 31 cancer-related sera 71 HCC and 64 healthy individuals by reverse transcription quantitative polymerase chain reaction...
Context: Icaritin (ICT), a prenylflavonoid derivative extracted from the Epimedium (Berberidaceae) genus, has been identified to exhibit antitumor effect in hepatocellular carcinoma (HCC) cells by inducing apoptosis. However, its on cellular senescence not elucidated. Objective: To investigate mechanism for low concentrations of ICT exerting activity through induction senescence. Materials and methods: Human HepG2 Huh7 were treated with (1 2 μM) once per day week. Cellular was evaluated cell...
Abstract LncRNA TP73 antisense RNA 1T (TP73-AS1) plays an important role in human malignancies. However, the levels of TP73-AS1 and its functional mechanisms pancreatic cancer metastasis remain unknown, clinical significance is also unclear. In present study, candidate target miR-141 adjacent normal tissue were detected using qRT-PCR. The association between clinicopathologic characteristics patients analyzed. relationship miR-141, 3-hydroxybutyrate dehydrogenase type 2 (BDH2) was confirmed...
Tumor necrosis factor (TNF)-alpha-induced protein 8 (TNFAIP8 or TIPE) is a recently identified considered to be associated with carcinogenesis. To investigate its expression pattern in pancreatic cancer patients and analyse correlation clinicopathological significance the levels of epithelial growth receptor (EGFR), immunohistochemistry was performed detect TNFAIP8 EGFR proteins cancers, pancreatitis tissues, healthy controls. The results showed stronger staining tissues compared normal...
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies with broad resistance to chemotherapeutic drugs. Krüppel-like factor 4 (KLF4) a candidate tumor suppressor in PDAC. However, precise role KLF4 gemcitabine PDAC remains largely unclear. In this study, we demonstrated that inhibited expression. Moreover, also reduced levels miR‑200b and miR‑183, but promoted ZEB1 expression cells. knockdown blocked inversely, overexpression suggesting positively regulated miR‑183....
The prognosis of hepatocellular carcinoma (HCC) treated by radiofrequency ablation (RFA) is mainly associated with tumor recurrence. So far, no tissue biomarker recurrence has been confirmed in biopsy specimens. Previous studies have reported that aberrant expression microRNA-34a (miR-34a) involved oncogenesis and progression HCC. aim this study was to investigate the prognostic value miR-34a patients HCC RFA. Patients early-stage single-nodule RFA were included, assessed quantitative...
Abstract Dysregulation of microRNAs (miRNAs) expression has been demonstrated in gastrointestinal stromal tumor (GIST). In this study, we aimed to determine the differential miRNAs GISTs and explore functional mechanism GIST cells. We measured six pairs tissues matched adjacent through a high‐throughput sequencing, which was confirmed 64 by real‐time polymerase chain reaction. found that miR‐4510 significantly downregulated compared control tissues. Luciferase reporter assay identified...
G-protein-coupled receptors (GPCRs), the largest family of cell-surface molecules involved in a number biological and pathological processes, have recently emerged as key players carcinogenesis cancer progression. Orphan G protein-coupled (oGPCRs) are group proteins lacking endogenous ligands. GPR137, one novel oGPCR genes, was discovered by homology screening. However, role GPR137 cancers has not yet been discussed is great therapeutic interest. In this study, we knocked down via lentivirus...
Colorectal cancer (CRC) is the third most commonly diagnosed and second highest cause of cancer‑associated death worldwide. Talin1 activates integrins, which mediate cell adhesion, proliferation, tumorigenesis metastasis. The aim present study was to determine talin1 expression levels in colorectal investigate role CRC proliferation invasion vitro vivo. protein were detected human adjacent normal tissues by immunohistochemistry. short hairpin RNA control vectors designed stably transfected...
Double Primary Hepatic Cancer (DPHC) which refers to synchronous hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) coexisting in the same liver, has rarely been reported. Here we discussed clinical characteristics, diagnosis, treatment, prognosis of DPHC based on an analysis 12 cases. Meanwhile, data 60 HCC cases ICC were collected at a ratio 5:1 with matched age gender period. A total 4,626 primary liver cancer screened, proportion was approximately 0.26%. Hepatitis B...
A kind of tumor targeting nitric oxide donor nanoparticle with brushes is described in this paper. The poly(4-vinylphenylboronic acid) polymeric brush, which shows glucose and pH dual responsiveness, endows the ability hollow S-nitrosothiols to accurate recognition binding sialic acid over-expressed type cells, such as HepG2 MCF-7 cells. In vitro experiments, including cells capture release confocal fluorescence microscope characterization, cytotoxicity assay different demonstrate selective...
Following the publication of this paper, authors contacted office to inform us that they had made errors in compilation tumour images shown Fig. 4A. Further contact we received from these authors, an independent enquiry was conducted Editorial office, after which were able ascertain data question appeared slightly modified form another written by different 6 years previously. Owing fact contentious above article already been published elsewhere prior its submission <em>Oncology Letters</em>,...
Objective To investigate the role of motility Oddi's sphincter in pigment gallbladder stone formation model guinea pigs.Methods Thirty-four general adult male Hartley pigs were divided randomly into two groups.Control group (10 pigs)and groups (24 pigs,which 4 subgroups with 6 each according to time they sacrificed),fed lithogenic diet.After 3,6,9 and 12 weeks later,Oddi's manometry myoelectric activity record obtained by multifunctional physiograph at stage.Results The incidence gallstone...
Objective To investigate the role of Oddi sphincter motility in cholesterol gallbladder stone formation model guinea pigs. Methods Thirty-four adult male Hartley pigs were divided randomly into two groups, control group (10 pigs) and groups (divided 4 subgroups with 6 each according to time they sacrificed). The animals fed lithogenic diet sacrificed after 3, 6, 9 12 weeks. Sphincter manometry recording myoelectric activity obtained by multifunctional physiograph at...