A5010924367- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- Inflammasome and immune disorders
- Trace Elements in Health
- Nutrition and Health in Aging
- Drug-Induced Hepatotoxicity and Protection
- TGF-β signaling in diseases
- Inflammatory Bowel Disease
- Mesenchymal stem cell research
- Organ Transplantation Techniques and Outcomes
- Endoplasmic Reticulum Stress and Disease
- Hepatocellular Carcinoma Treatment and Prognosis
- Systemic Lupus Erythematosus Research
- Head and Neck Cancer Studies
- Plant Virus Research Studies
- Phagocytosis and Immune Regulation
- Plant Pathogenic Bacteria Studies
- Pathogenesis and Treatment of Hiccups
- Peroxisome Proliferator-Activated Receptors
- Heavy Metal Exposure and Toxicity
- ATP Synthase and ATPases Research
- Breastfeeding Practices and Influences
- Hepatitis Viruses Studies and Epidemiology
Sun Yat-sen University
2007-2023
Third Affiliated Hospital of Sun Yat-sen University
2011-2023
Anhui Medical University
2018-2022
First Affiliated Hospital of Anhui Medical University
2018-2022
The University of Queensland
2021
Agriculture and Food
2021
Wuhu Fourth People Hospital
2021
Xian Yang Central Hospital
2021
Mortality from hepatitis B virus (HBV)–related acute‐on‐chronic liver failure (ACLF) is high due to limited treatment options. Preclinical and clinical investigations have proved that with mesenchymal stromal cells (MSCs) beneficial for recovery injury. We hypothesized the outcome of HBV‐related ACLF would be improved by MSC treatment. From 2010 2013, 110 patients were enrolled in this open‐label, nonblinded randomized controlled study. The control group (n = 54) was treated standard medical...
Aberrant TGF‑β/Smad7 signaling has been reported to be an important mechanism underlying the pathogenesis of ulcerative colitis. Therefore, present study aimed investigate effects a number potential anti‑colitis agents on intestinal epithelial permeability and pathway in experimental model A mouse colitis was first established before anti‑TNF‑α 5‑aminosalicyclic acid (5‑ASA) were administered intraperitoneally orally, respectively. Myeloperoxidase (MPO) activity, histological index (HI)...
Abstract The efficacy of prenatal antiviral therapy (AVT) for preventing the vertical transmission hepatitis B virus (HBV) is well demonstrated. However, data are limited regarding safety postpartum cessation AVT, which may induce alanine aminotransferase (ALT) elevation. We aimed to investigate necessity prolonging maternal AVT after delivery. Chronic mothers at immune‐tolerant phase with HBV DNA levels >6 log 10 IU/mL were prospectively enrolled and received during third trimester until...
Background and Aims . We aimed to ascertain the feasibility safety of NA cessation, status patients after predictive factors for relapse subsequent retreatment. Methods A total 92 were enrolled in this prospective study. Patients monitored every month first 3 months cessation thereafter. Results Sixty-two finished 48 weeks follow-up. None died or developed liver failure, cirrhosis, HCC. The 62 could be divided into 4 categories according 48-week clinical development relapse. Virologic...
Aims. The aim is to evaluate the efficacy and safety of Sofosbuvir- (SOF-) based direct-acting antiviral agents (DAAs) treatment for patients with genotype (GT) 3/6 hepatitis C virus (HCV) infection. Methods. Patients infected GT HCV treated SOF-based DAAs were enrolled in this prospective, open, single-center, real-world study. Drugs included Sofosbuvir (SOF), Velpatasvir (VEL), Daclatasvir (DCV), Ribavirin (RBV). regimens SOF + RBV 24 weeks, DCV ± 12/24 SOF/VEL 12 weeks. Results. A total...
It has been suggested that Bax translocation to the mitochondria is related apoptosis, and cytosol acidification contributes apoptosis events. However, mechanisms remain obscure. We investigated effect of on ultraviolet (UV) light-induced apoptosis. The assay in vitro showed translocated at pH 6.5, whereas no was observed 7.4. VHDBB cells expressing GFP-Bax fusion protein were treated for 12 h with a 6.5 DMEM medium, nigericin (5 mug/ml) UV light (50 J/cm(2)), separately or combination,...
Abstract Background Previous studies have found that the production of platelets could enhance therapeutic effects stem cells. Nevertheless, there are still no articles reporting on relationship between and clinical efficacy umbilical cord mesenchymal cells (UCMSCs) for HBV-related acute-on-chronic liver failure (ACLF) cirrhosis (LC). Methods In this retrospective observational study, patients who met criteria were included. Patients divided into subgroups according to aims study. first...
Objective: To evaluate the efficacy and safety of DCV-based DAAs therapy for chronic HCV infected Chinese patients. Methods: An open-label, non-randomized, prospective study was designed. Fifty-two patients with infection were enrolled. Among them, there one patient after liver transplantation, 2 kidney 3 hepatocellular carcinoma, 4 HBV infection. Thirteen cases hepatitis C (one compensated cirrhosis) who negative resistance-related variants [NS5A RAS (-)] gene 1b NS5A treated daclatasvir...
Abstract Background Induction chemotherapy (IC) comprising docetaxel, cisplatin, and fluorouracil (TPF), combined with concurrent chemoradiotherapy (CCRT) effectively improves the survival rate of locally advanced nasopharyngeal carcinoma (LA‐NPC). Selecting patients whose risk tumor recurrence metastasis is high appropriate intensity a concern. We tumor‐node‐metastasis staging load Epstein–Barr virus (EBV) after IC to select individualized strength. Methods The clinical data prognostic...
Kruppel-associated box (KRAB) proteins reportedly play a dual role in neoplastic transformation. At present, little is known about the function of encoded by human pogo transposable element derived with KRAB domain (POGK) gene. Herein, we evaluated prognostic significance POGK expression patients hepatocellular carcinoma (HCC).The data HCC was downloaded from The Cancer Genome Atlas (TCGA) database. To determine relationship between and clinical features, logistic regression applied. Cox...
There is currently no single model for predicting Wilson's disease (WD). We aimed to create a nomogram using daily clinical parameters improve the accuracy of WD diagnosis in patients with abnormal liver function. Between July 2016 and December 2020, we identified 90 function who had homozygous or compound heterozygous mutations ATP7B gene. The control group included 128 similar but during same time period. To nomogram, screened potential predictive variables least absolute shrinkage...
We generated an Immuno-Clinic score (ICS) model to evaluate T cell immunity based on the clustering of antiviral cytokines and inhibitory molecules in 229 naïve chronic hepatitis B (CHB) patients. 126 patients receiving therapy were used validate for predicting effectiveness. Through receiver-operator characteristic curve analysis, area under curve, sensitivity, specificity ICS 0.801 (95%CI 0.703-0.900), 0.727, 0.722, respectively. The cut-off value was 0.442. Re-evaluation different phases...
Objectives The optimal treatment of hepatitis C virus (HCV) genotype 6 is unclear owing to its limited geographic distribution. Because a high predictive value rapid virological response (RVR) for sustained (SVR), we conducted an open-label randomized controlled trial compare 24- and 48-week peginterferon/ribavirin combination therapy patients with HCV in Southern China who achieved RVR. Methods Findings Treatment-naive, non-cirrhotic chronic were treated pegylated interferon α-2a (180...
Abstract Background We encourage Hepatitis B virus-infected mothers to breastfeed postpartum, even when continuing pregnancy category nucleos(t)ide analogs (NAs) treatment. However, a large proportion of the were noncompliant with this breastfeeding recommendation. This study aimed investigate factors associated noncompliance recommendation in who had received NAs treatment during pregnancy. Methods A total 155 chronic hepatitis receiving for preventing mother-to-child transmission late...
Abstract Background The prevalence of zinc deficiency is high in patients with chronic liver disease, but few studies have hitherto explored the relationship between serum level and hepatitis B virus (HBV)-related acute-on-chronic failure (ACLF). This study aimed to assess association infectious complications, model for end-stage disease (MELD) score HBV-related ACLF. Methods Patients ACLF from Department Infectious Diseases Third Affiliated Hospital Sun Yat-sen University (Guangzhou, China)...
Background: The objective of this study is to analyze the causes nontreatment among patients with hepatitis C virus (HCV) infection and increase cure rate chronic in Guangdong Province. Methods:We performed both retrospective survey prospective a cohort 435 outpatients our center subjective HCV non-treatment.Results: Among 1,931 patients, did not receive anti-viral therapy (AVT), and, 37 these load was persistently negative.In remaining 398 RNA repeatedly tested positive.The included...
To investigate the safety and efficacy of direct-acting antiviral (DAA) regimens in a cohort Chinese patients with chronic hepatitis C virus (HCV) infection. A total 222 adult were enrolled treated via DAA accordance HCV management guidelines. Treatment responses evaluated 4 weeks after treatment, at end treatment (EOT) 12 post-treatment. Virological responses, biochemical model for end-stage liver disease (MELD) Child-Pugh (CP) scores recorded. 218 (98.2%) achieved sustained virological...
Chronic hepatitis B (CHB) patients have a high virological relapse rate after cessation of nucleos(t)ide analog (NA) treatment, but the clinical outcome remains unclear. This study aimed to investigate 96-week outcomes and risk factors for in CHB NAs.This was prospective trial; 74 eligible were enrolled. The underwent NA follow-up according 2012 Asian Pacific Association Study Liver Guideline. Symptoms, biochemical (aspartate aminotransferase [AST], alanine [ALT], total bilirubin, urea...
Introduction Combination antiviral therapy of nucleos(t)ide analogue (NA) and pegylated interferon alpha (peg-IFN alpha) decrease hepatitis B virus (HBV) surface antigen (HBsAg) levels to achieve functional cure improve long-term prognosis in chronic patients. However, for B-related liver fibrosis, studies on combination these two medicines are limited. This study was designed compare the efficacy between peg-IFN combined with tenofovir (TDF) TDF monotherapy clearance HBsAg NA-experienced...
Abstract Background: It is well-established that immune checkpoint inhibitors-induced immune-mediated hepatitis (ICIs-IMH) in patients with hepatocellular carcinoma (HCC) increases susceptibility to liver failure (LF). Given mounting evidence artificial support system (ALSS) treatment can effectively relieve both IMH and LF, a single-center, non-blinded, randomized controlled clinical trial will be conducted investigate the efficacy safety of ALSS for HCC ICIs-LF. Methods analysis: Sixty...