A5100671581- HIV Research and Treatment
- Hepatitis B Virus Studies
- Immune Cell Function and Interaction
- Hepatitis C virus research
- Cytomegalovirus and herpesvirus research
- Liver Disease Diagnosis and Treatment
- Herpesvirus Infections and Treatments
- HIV-related health complications and treatments
- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Viral gastroenteritis research and epidemiology
- Pneumonia and Respiratory Infections
- Immunotherapy and Immune Responses
- Toxin Mechanisms and Immunotoxins
- Pediatric health and respiratory diseases
- Virus-based gene therapy research
- Respiratory viral infections research
- Toxoplasma gondii Research Studies
- RNA Interference and Gene Delivery
- Viral Infections and Outbreaks Research
- Calcium Carbonate Crystallization and Inhibition
- Blood groups and transfusion
- Enhanced Recovery After Surgery
- Malaria Research and Control
- Human Resource and Talent Management
Fudan University
2024-2025
National Institutes of Health
2021-2025
National Institute of Diabetes and Digestive and Kidney Diseases
2021-2025
First Affiliated Hospital Zhejiang University
2023
Zhejiang University
2013-2023
Shuguang Hospital
2022
Shanghai University of Traditional Chinese Medicine
2022
UNSW Sydney
2022
Third Affiliated Hospital of Sun Yat-sen University
2020
Sun Yat-sen University
2020
HBV genotype A has two major subtypes, A1 (commonly in Africa) and A2 Europe) with only 4% nucleotide differences. Individuals infected these subtypes appear to have different clinical manifestations virologic features. Whether such a difference results from the virus or host not been established. Using generated molecule clones of cell culture (HBVcc), we demonstrate that HBVcc can be passaged vitro vivo respond equally well human IFN-α treatment. liver chimeric mice (HBVmp) hepatocytes...
Intracellular parasites, such as T. gondii, present a plurality of antigens because the complexity its life cycle. Compound DNA vaccines bring new approach and hope for treatment toxoplasmosis. In this study, vaccine encoding two major surface SAG1, SAG3 from with A2/B subunit cholera toxin genetic adjuvant was constructed. BALB/c mice were immunized intramuscularly PBS, pcDNA3.1, pSAG1, pSAG1/SAG3 pSAG1/SAG3-CTXA2/B three times separately. Immunized tested IgG antibody IFN-γ IL-4 production...
Objective To longitudinally investigate the role of FoxP3+ Regulatory T cells (Treg) and interleukin17-producing helper 17 (Th17) in De Novo Hepatitis B Virus infection after orthotopic Liver Transplantation (DNHB-OLT), analyze possible correlation between these HBV clearance disease. Methods We enrolled 12 control cases (OLT) 24 patients, including diagnosed with DNHB-OLT Acute (AHB), into study from liver transplantation research center at Beijing 302 Hospital. Flow cytometry was used to...
Although liver transplantation is one of the most efficient curative therapies end stage diseases, recipients may suffer graft loss opst-operation. IRF-5, a member Interferon Regulatory Factors, functions as key regulator in TLR4 cascade, and capable inducing inflammatory cytokines. has been proved to contribute acute allograft rejection, including after transplantation, correlation between IRF5 gene rejection not elucidated yet.The study enrolled total 289 recipients, 39 females 250 males,...
Hepatitis B virus (HBV) remains a major public health threat with nearly 300 million people chronically infected worldwide who are at high risk of developing hepatocellular carcinoma. Current therapies effective in suppressing HBV replication but rarely lead to cure. do not affect the covalently closed circular DNA (cccDNA), which serves as template for viral transcription and is highly stable cells ensure persistence. In this study, we aim identify elucidate functional role...
Vaccination with radiation-attenuated sporozoites has been shown to induce CD8+ T cell-mediated protection against pre-erythrocytic stages of malaria. Empirical evidence suggests that successive inoculations often improve the efficacy this type vaccines. An initial dose (prime) triggers a specific cellular response, and subsequent (boost) amplify response create robust cell memory. In work we propose model analyze effect dynamics on performance prime-boost This boost doses timings should be...
ABSTRACT Natural killer (NK) cells, natural T (NKT) and lymphocytes were analyzed by using a flow cytometer in 225 human immunodeficiency virus (HIV)-positive individuals infected through the past sale of blood plasma without receiving antiretroviral therapy People’s Republic China. According to CD4 T-cell counts these HIV-infected adults stratified into three groups: long-term slow progressors, subjects, AIDS patients. NK cell progressors higher compared HIV infection patients ( P <...
We generated an Immuno-Clinic score (ICS) model to evaluate T cell immunity based on the clustering of antiviral cytokines and inhibitory molecules in 229 naïve chronic hepatitis B (CHB) patients. 126 patients receiving therapy were used validate for predicting effectiveness. Through receiver-operator characteristic curve analysis, area under curve, sensitivity, specificity ICS 0.801 (95%CI 0.703-0.900), 0.727, 0.722, respectively. The cut-off value was 0.442. Re-evaluation different phases...
Objective To investigate the immunogenicity and safety of co-immunization children with live attenuated varicella-zoster virus (VZV) vaccine hepatitis A (HAV) vaccine. Methods A total 686 aged 18-24 months were recruited in Henan province China divided into three groups. Children groups respectively immunized VZV or HAV alone combination. Blood samples collected from all subjects before one month after vaccination for detection seroconversion seropositive rates. Occurrence adverse...