A5101666578- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- RNA modifications and cancer
- Liver Disease and Transplantation
- Cancer-related gene regulation
- Chronic Kidney Disease and Diabetes
- Epigenetics and DNA Methylation
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Immune Cell Function and Interaction
- HIV/AIDS drug development and treatment
- MicroRNA in disease regulation
- Reproductive biology and impacts on aquatic species
- Neonatal Respiratory Health Research
- Immunotherapy and Immune Responses
- Aquaculture disease management and microbiota
- Traditional Chinese Medicine Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiac Fibrosis and Remodeling
- Immune cells in cancer
- Fungal Infections and Studies
- Respiratory Support and Mechanisms
- Cancer-related molecular mechanisms research
- Endoplasmic Reticulum Stress and Disease
- Cell death mechanisms and regulation
Shanghai Public Health Clinical Center
2024-2025
Sun Yat-sen University
2012-2024
Third Affiliated Hospital of Sun Yat-sen University
2012-2024
Renji Hospital
2024
State Key Laboratory of Oncogene and Related Genes
2024
Shanghai Jiao Tong University
2020-2024
First Affiliated Hospital of Zhengzhou University
2023-2024
Third Affiliated Hospital of Southern Medical University
2012-2022
XinHua Hospital
2020-2021
Shanghai Sixth People's Hospital
2021
RNA 5-methylcytosine (m5C) is an abundant chemical modification in mammalian RNAs and plays crucial roles regulating vital physiological pathological processes, especially cancer. However, the dysregulation of m5C its underlying mechanisms non-small cell lung cancer (NSCLC) remain unclear. Here we identified that NSUN2, a key methyltransferase, highly expressed NSCLC tumor tissue. We found elevated NSUN2 expression levels strongly correlate with grade size, predicting poor outcomes for...
Oxidative stress plays a critical role in the development of cardiac remodeling and heart failure. Lutein, predominant nonvitamin A carotenoid, has been shown to have profound effects on oxidative stress. However, effect lutein angiotensin II (Ang II)-induced failure remains unknown. The aim this study was determine whether is involved elucidate underlying molecular mechanisms. In vitro experiments with isolated neonatal rat cardiomyocytes (NRCMs) fibroblasts (CFs) revealed that...
Reactive oxygen species (ROS) play a pivotal role in the development of pathological cardiac hypertrophy.Delphinidin, natural flavonoid, was reported to exert marked antioxidative effects.Therefore, we investigated whether delphinidin ameliorates hypertrophy via inhibiting oxidative stress.In this study, male C57BL/6 mice were treated with DMSO or after surgery.Neonatal rat cardiomyocytes (NRCMs) angiotensin II (Ang II) and vitro.Eighteen-month-old administered investigate effect on...
Introduction. Lamivudine plus dolutegravir (3TC/DTG) and bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) regimens are commonly used as first-line treatments for people living with human immunodeficiency virus (HIV) (PLWH) worldwide.Gap Statement. There limited comparative data on the antiviral activity safety between these in ART-naive PLWH, particularly China, where 3TC/DTG regimen was integrated into therapy 2021 gained broader adoption after its inclusion National Health...
Introduction: Sepsis is a leading cause of death among patients with HIV, but early diagnosis remains challenge. This study evaluates the diagnostic performance monocyte distribution width (MDW) in detecting sepsis HIV.
Diabetic hyperglycemia damages peripheral nerves by triggering ischemia, oxidative stress, and inflammation. Alpha-lipoic acid (ALA) methylcobalamin (MC) are known to improve signs of diabetic neuropathy (DPN), possibly enhancing neural vascular endothelial cell metabolism antioxidant capacity. We evaluated differences in efficacy following short-term MC or ALA treatment on DPN symptoms guide clinical drug selection.Forty patients were randomly divided into groups (both N.=20) assessed the...
The intestinal microflora plays a major role in human health. Intestinal flora imbalances are seen clinical settings, such as cirrhosis, which bacterial translocation (BT) results migration of bacteria or products from the lumen to extraintestinal sites. In this study, we explored effect alterations gut on BT and liver function cirrhotic rats.In used carbon tetrachloride-induced rat model compare abundance aerobic anaerobic species healthy rats. We antibiotic (norfloxacin) different...
ObjectiveTo the best of our knowledge, association insulin resistance (IR) with chronic kidney disease (CKD) has not been well studied in normal-weight individuals. The aim this study is to examine whether IR associated CKD non-diabetic subjects normal weight. We also presence obesity modifies CKD. MethodsData were drawn from a cross-sectional survey China. Both estimated glomerular filtration rate and urinary albumin creatinine ratio used as markers Logistic regression models quartiles...
// Weichao Zhong 1, 2, * , Lei Gao Zhenting Zhou 1 Haiyan Lin Chun Chen 3 Peng Huang Weiliang Chuying Shaohui Linghui Nie Ye Liu 4 Youming Daqiao 2 and Zhiping Lv School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, 510515, China Department Liver Diseases, Shenzhen Medicine Hospital, Shenzhen, 518033, Pharmacology, Shantou University College, Shantou, 515041, The Third Affiliated Hospital 510630, These authors contributed equally to this work...
In order to develop excellent germplasm resources for giant grouper (Epinephelus lanceolatus), cryopreservation of sperm was examined in the present study. Firstly, 13 kinds dilution (ELS1-3, EM1-2, TS-2, MPRS, ELRS0-6) were prepared with physiological salt, sucrose, glucose and fetal bovine serum. The parameters ELRS3 (ratio fast motion, ratio slow time lifespan motility) ELS3 (sperm motion significantly higher than those other dilutions (P < 0.05). Secondly, after adding 15% DMSO 10% FBS...
Clustered regularly interspaced short palindromic repeats (CRISPR)-Cas12a nucleases have emerged as a promising alternative to CRISPR-Cas9 in gene editing and expression regulation. However, the adoption of Cas12a has been hindered due general off-target activities limited efficiency. Here, we utilized hybrid engineered variant hairpin-spacer crRNAs (h-CAP) enhance specificity efficiency CRISPR-Cas12a system. Leveraging h-CAP strategy, demonstrate both single-base-specific multiplex...
High serum levels of lipopolysaccharide (LPS) with LPS-MD-2/TLR4 complex activated NF-kb and cytokine cause hepatic necrosis in animal models. We investigated the dynamic changes LPS patients acute on chronic hepatitis B liver failure (ACHBLF).We enrolled ACHBLF for a 12-week study. Patients' were measured along 10 healthy controls. Patients supportive care recovered without intervention(s) analyzed. during disease progression phase, peak remission phase compared controls.Among 30 enrolled,...
Abstract Background Adefovir dipivoxil ( ADV ) is a nucleotide analogue with proven efficacy in chronic hepatitis B CHB ). Aims This study investigated long‐term treatment HBeAg ‐positive patients. Methods A total of 480 C hinese subjects who participated 1‐year, double‐blind, placebo‐controlled 10 mg daily were offered open‐label continuation for further 208 weeks. Results 390 completed 5 years treatment. Baseline median virus HBV DNA was 8.8 log copies/ml and alanine aminotransferase ALT...
To explore the relationship between metabolic syndrome (MS) and risk for chronic kidney disease (CKD) in a Southern Chinese population.A cross-sectional study was conducted 1724 community-based participants from June to October 2012. The prevalence of MS (as defined by International Diabetes Federation) CKD (defined as an estimated glomerular filtration rate <60 mL/min per 1.73 m(2) and/or albuminuria) determined. association then analyzed using STATA software.Metabolic significantly...
There are common significant character differences between genders in many fish. The sex-specific genetic markers important tools for research and industry. Golden pompano (Trachinotus blochii) is a commercial mass-produced species with sex growth differences. Our study includes the whole genome re-sequencing data of T. blochii from four populations. A total 2,183,486 high-quality clean reads were obtained subsequent information analysis. Association analysis single nucleotide polymorphism...
Background The prevalence of chronic kidney disease (CKD) and prediabetes has increased in China, at different rates locations. Therefore a community-based screening research was conducted order to determine the CKD prediabetes, analyze associated risk factors city Southern China. Methods Atotal 7801 community residents aged 18 year older from 6 communities were screened by stratified random cluster sampling method. An estimated glomerular filtration rate (eGFR), albuminuria, fasting plasma...
There is no general consensus on possible factors associated with microalbuminuria in hypertensive patients nor any reported study about this issue Chinese patients. To examine issues, 944 were enrolled a based cross-sectional survey conducted Southern China. Multivariate regression analyses performed to identify the related presence of and urinary excretion albumin. The prevalence non-diabetic 17.16% 15.25%, respectively. Body mass index (BMI), but not waist circumference (WC),...