A5101978999- Optical Imaging and Spectroscopy Techniques
- Neuropeptides and Animal Physiology
- Non-Invasive Vital Sign Monitoring
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Heart Rate Variability and Autonomic Control
- Neuroinflammation and Neurodegeneration Mechanisms
- Nanoparticle-Based Drug Delivery
- Genetic Associations and Epidemiology
- Nanoplatforms for cancer theranostics
- Ferroptosis and cancer prognosis
- Renal and related cancers
- Cancer, Stress, Anesthesia, and Immune Response
- Hepatocellular Carcinoma Treatment and Prognosis
- Genetic Syndromes and Imprinting
- Ion Transport and Channel Regulation
- Renal function and acid-base balance
- RNA Research and Splicing
- Receptor Mechanisms and Signaling
- Nitric Oxide and Endothelin Effects
- Neurological Disease Mechanisms and Treatments
- Liver Disease Diagnosis and Treatment
- Lung Cancer Research Studies
- Reproductive System and Pregnancy
- Cancer, Hypoxia, and Metabolism
West China Hospital of Sichuan University
2023-2025
Third Affiliated Hospital of Guangzhou Medical University
2023-2025
Guangzhou Medical University
2023-2025
Sichuan University
2023-2025
Army Medical University
2007-2024
Xinqiao Hospital
2007-2024
Qingdao University
2020-2024
Qingdao Municipal Hospital
2021-2024
Affiliated Hospital of Qingdao University
2021-2024
First Affiliated Hospital of Anhui Medical University
2021-2024
Immunotherapy has evolved as a critical option to treat diverse cancers. The active response immunotherapy relies on the unique interaction between cancer and tumor microenvironment (TME). Angiogenesis is one of hallmarks cancer. However, association angiogenesis clinical outcome, immune cell infiltration, remains unknown in gastric (GC).We systematically assessed 36 angiogenesis-associated genes (AAGs) comprehensively identified correlation transcriptional patterns, prognosis, infiltration....
The study aims to assess the spontaneous oscillations in elderly subjects based on wavelet transform of cerebral oxygenation (CO) and arterial blood pressure (ABP) signals. Continuous recordings near-infrared spectroscopy (NIRS) ABP signals were obtained from simultaneous measurements 20 young (age: 27.3 ± 7.1 years) 15 70.8 5.1 at rest. Using spectral analysis transform, five frequency intervals identified (I, 0.005 0.02 Hz; II, 0.06 III, 0.15 IV, 0.40 V, 2.0 Hz). average amplitudes Δ[HbO 2...
Endometriosis is an estrogen-dependent chronic inflammatory disease. Hormonal and surgical treatments are the most commonly used clinical therapies, but they have many sides effects or traumatic to body. Therefore, specific drugs for endometriosis treatment urgently needed develop. In this study, we identified two features of endometriosis, namely continuous recruitment neutrophils into ectopic lesions higher uptake glucose by cells. For above features, designed a oxidase-loaded bovine serum...
Rationale: Tumor ablation can cause severe pain to patients, but there is no satisfactory means of analgesia available.In addition, recurrence residual tumors due incomplete threatens patient safety.Photothermal therapy (PTT), a promising approach for tumor ablation, also faces the aforementioned problems.Therefore, developing novel photothermal agents that efficiently relieve PTT-associated and potentiate PTT efficacy are urgently needed.Methods: The Pluronic F127 hydrogel doped with...
Background Dexmedetomidine has repeatedly shown to improve anxiety, but the precise neural mechanisms underlying this effect remain incompletely understood. This study aims explore role of corticotropin-releasing hormone–producing hypothalamic paraventricular nucleus (CRH PVN ) neurons in mediating anxiolytic effects dexmedetomidine. Methods A social defeat stress mouse model was used evaluate induced by dexmedetomidine through elevated plus maze, open-field test, and measurement serum...
Purpose: Resting‐state functional connectivity in subjects with cerebral infarction (CI) was assessed using wavelet‐based coherence analysis of near‐infrared spectroscopy (NIRS) signals. Methods: Continuous recordings NIRS signals were measured from the prefrontal cortex and sensorimotor cortical areas 12 CI (CI group) 16 healthy (healthy during resting state. The channels these divided into four connection types: homologous connectivity, frontoposterior contralateral homolateral...
Recent studies have shown 5-hydroxymethyl-2-furfural (5-HMF) has favorable biological effects, and its neuroprotection in a variety of neurological diseases been noted. Our previous study showed that treatment 5-HMF led to protection against permanent global cerebral ischemia. However, the underlying mechanisms ischemic injury are not fully understood. This was conducted investigate neuroprotective effect elucidate nuclear factor erythroid 2-related 2 (Nrf2)/antioxidant response element...
Combination therapy such as photodynamic (PDT)-enhanced chemotherapy is regarded a promising strategy for cancer treatment. Boron-dipyrromethene (BODIPY), close relatives of porphyrins, was widely used in PDT. However, poor water solubility, rapid metabolism by the body and lack targeting limits its clinical application. Lenvatinib, first-line drug molecular-targeted liver cancer, restricted application side effects. Herein, to achieve synergy between PDT chemotherapy, we synthesized two...
Abstract Background Breast cancer (BC) poses an increasing threat to women’s health, yet its characteristics in women of childbearing age (WCBA) are infrequently reported. This study aims investigate the patterns and trends BC incidence among WCBA over past decades. Materials methods focuses on aged 15–49 years, consistent with WHO definition WCBA. Estimates 95% uncertainty intervals (UIs) for were obtained from Global Burden Diseases Study 2021. We utilized age-period-cohort (APC) model...
Intracellular parasites, such as T. gondii, present a plurality of antigens because the complexity its life cycle. Compound DNA vaccines bring new approach and hope for treatment toxoplasmosis. In this study, vaccine encoding two major surface SAG1, SAG3 from with A2/B subunit cholera toxin genetic adjuvant was constructed. BALB/c mice were immunized intramuscularly PBS, pcDNA3.1, pSAG1, pSAG1/SAG3 pSAG1/SAG3-CTXA2/B three times separately. Immunized tested IgG antibody IFN-γ IL-4 production...
Purpose: The objective of this study was to assess the spontaneous cerebral oscillations based on wavelet transform near‐infrared spectroscopy (NIRS) signals in subjects at risk for atherosclerotic stroke. Methods: A total 32 were recruited from university participate study: 20 normal (age = 59.6 ± 10.2 year) and other 12 ischemic stroke 60.2 10.1 year). oxygenation signal monitored 10 min left prefrontal lobe using NIRS. Results: With spectral analysis transform, five frequency intervals...