A5002052272- Advanced MRI Techniques and Applications
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Cancer-related molecular mechanisms research
- Cervical Cancer and HPV Research
- Esophageal Cancer Research and Treatment
- Viral-associated cancers and disorders
- Molecular Biology Techniques and Applications
- Cholangiocarcinoma and Gallbladder Cancer Studies
Sun Yat-sen University
2021-2022
Sun Yat-sen University Cancer Center
2021-2022
State Key Laboratory of Oncology in South China
2022
Abstract Purpose: Our goal was to demonstrate that lymphatic drainage fluid (lymph) has improved sensitivity in quantifying postoperative minimal residual disease (MRD) locally advanced human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) compared with plasma, and leverage this novel biofluid for patient risk stratification. Experimental Design: We prospectively collected lymph samples from neck drains of 106 patients HPV (+) OPSCC, along 67 matched plasma...
ABSTRACT Relapse is a major cause of failure after surgery in HPV-human papillomavirus (HPV) negative head and neck squamous cell carcinoma (HNSCC),), with up to 50% patients recurring within 2 years. While clinicopathologic criteria exist for adjuvant treatment, these are imprecise have not changed decades. However, no reliable method exists tailor therapy individual based on risk recurrence surgery. Using an ultra-sensitive targeted sequencing approach, we demonstrate that circulating...
Abstract Background Induction chemotherapy (IC) comprising docetaxel, cisplatin, and fluorouracil (TPF), combined with concurrent chemoradiotherapy (CCRT) effectively improves the survival rate of locally advanced nasopharyngeal carcinoma (LA‐NPC). Selecting patients whose risk tumor recurrence metastasis is high appropriate intensity a concern. We tumor‐node‐metastasis staging load Epstein–Barr virus (EBV) after IC to select individualized strength. Methods The clinical data prognostic...
Objective: This study aims to compare the treatment outcomes of concurrent chemoradiotherapy (CCRT) versus radiotherapy (RT) alone in stage II nasopharyngeal carcinoma (NPC) patients. Methods: We retrospectively collected 601 NPC patients treated two hospitals between June 2003 2016. All were divided into CCRT group ( n = 255) and RT 346). Overall survival (OS), locoregional failure-free (LRFFS), progression-free (PFS), distant metastasis-free (DMFS) assessed using Kaplan-Meier method. The...
<p>Characterization of lymphatic cfDNA and development a liquid biopsy assay</p>
<p>HPV (+) OPSCC recurrences stratified by postoperative lymph cf-HPV detection, plasma or high-risk pathology.</p>
<p>Blood contamination does not significantly impact lymph cf-HPV measurement.</p>
<p>HPV (+) OPSCC recurrences stratified by postoperative lymph cf-HPV detection, plasma or high-risk pathology.</p>
<div>AbstractPurpose:<p>Our goal was to demonstrate that lymphatic drainage fluid (lymph) has improved sensitivity in quantifying postoperative minimal residual disease (MRD) locally advanced human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) compared with plasma, and leverage this novel biofluid for patient risk stratification.</p>Experimental Design:<p>We prospectively collected lymph samples from neck drains of 106 patients HPV (+)...
<p>Blood contamination does not significantly impact lymph cf-HPV measurement.</p>
<p>Cell-free HPV is enriched in the lymph relative to patient-matched plasma and does not correlate with primary tumor features or smoking history</p>
<div>AbstractPurpose:<p>Our goal was to demonstrate that lymphatic drainage fluid (lymph) has improved sensitivity in quantifying postoperative minimal residual disease (MRD) locally advanced human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) compared with plasma, and leverage this novel biofluid for patient risk stratification.</p>Experimental Design:<p>We prospectively collected lymph samples from neck drains of 106 patients HPV (+)...
<p>Designing a machine learning model that integrates postoperative lymph and plasma MRD to stratify outcomes</p>
<p>Designing a machine learning model that integrates postoperative lymph and plasma MRD to stratify outcomes</p>
<p>Supplementary methods found here.</p>
<p>Lymph cf-HPV levels are not significantly impacted by surgical variables</p>
<p>Characterization of lymphatic cfDNA and development a liquid biopsy assay</p>
<p>Cell-free HPV is enriched in the lymph relative to patient-matched plasma and does not correlate with primary tumor features or smoking history</p>
<p>Lymph cf-HPV levels are not significantly impacted by surgical variables</p>