A5039948512- Advanced MRI Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Head and Neck Cancer Studies
- Pharmacological Effects and Toxicity Studies
- Iron Metabolism and Disorders
- Lung Cancer Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Erythropoietin and Anemia Treatment
Washington University in St. Louis
2023
University of Utah
1995
Burn Institute
1995
Regional Medical Center
1995
To evaluate the effects of recombinant human erythropoietin (r-HuEPO) in attempting to prevent anemia acutely burned patients.Prospective double-blind randomized study 40 patients.Patients with burns from 25% 65% total body surface were enrolled. r-HuEPO or a placebo was begun within 72 hours admission. Cell blood count, reticulocyte counts, transfusion requirements, and loss measured. Comparison carried out by unpaired t test.There no statistically significant difference hemoglobin,...
Abstract Purpose: Our goal was to demonstrate that lymphatic drainage fluid (lymph) has improved sensitivity in quantifying postoperative minimal residual disease (MRD) locally advanced human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) compared with plasma, and leverage this novel biofluid for patient risk stratification. Experimental Design: We prospectively collected lymph samples from neck drains of 106 patients HPV (+) OPSCC, along 67 matched plasma...
<p>Characterization of lymphatic cfDNA and development a liquid biopsy assay</p>
<p>HPV (+) OPSCC recurrences stratified by postoperative lymph cf-HPV detection, plasma or high-risk pathology.</p>
<p>Blood contamination does not significantly impact lymph cf-HPV measurement.</p>
<p>HPV (+) OPSCC recurrences stratified by postoperative lymph cf-HPV detection, plasma or high-risk pathology.</p>
<div>AbstractPurpose:<p>Our goal was to demonstrate that lymphatic drainage fluid (lymph) has improved sensitivity in quantifying postoperative minimal residual disease (MRD) locally advanced human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) compared with plasma, and leverage this novel biofluid for patient risk stratification.</p>Experimental Design:<p>We prospectively collected lymph samples from neck drains of 106 patients HPV (+)...
<p>Blood contamination does not significantly impact lymph cf-HPV measurement.</p>
<p>Cell-free HPV is enriched in the lymph relative to patient-matched plasma and does not correlate with primary tumor features or smoking history</p>
<div>AbstractPurpose:<p>Our goal was to demonstrate that lymphatic drainage fluid (lymph) has improved sensitivity in quantifying postoperative minimal residual disease (MRD) locally advanced human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) compared with plasma, and leverage this novel biofluid for patient risk stratification.</p>Experimental Design:<p>We prospectively collected lymph samples from neck drains of 106 patients HPV (+)...
<p>Designing a machine learning model that integrates postoperative lymph and plasma MRD to stratify outcomes</p>
<p>Designing a machine learning model that integrates postoperative lymph and plasma MRD to stratify outcomes</p>
<p>Supplementary methods found here.</p>
<p>Lymph cf-HPV levels are not significantly impacted by surgical variables</p>
<p>Characterization of lymphatic cfDNA and development a liquid biopsy assay</p>
<p>Cell-free HPV is enriched in the lymph relative to patient-matched plasma and does not correlate with primary tumor features or smoking history</p>
<p>Lymph cf-HPV levels are not significantly impacted by surgical variables</p>