A5100616382- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Circular RNAs in diseases
- Glioma Diagnosis and Treatment
- Reproductive System and Pregnancy
- Ferroptosis and cancer prognosis
- Neuroscience and Neural Engineering
- Pluripotent Stem Cells Research
- Wound Healing and Treatments
- Retinal Development and Disorders
- Electrospun Nanofibers in Biomedical Applications
- Single-cell and spatial transcriptomics
- Epigenetics and DNA Methylation
- Stress Responses and Cortisol
- FOXO transcription factor regulation
- Retinal and Optic Conditions
- Organic and Inorganic Chemical Reactions
- Synthesis and Biological Activity
- Sesquiterpenes and Asteraceae Studies
- Plant-based Medicinal Research
- MRI in cancer diagnosis
- Plant Toxicity and Pharmacological Properties
- Ion channel regulation and function
- Seaweed-derived Bioactive Compounds
- RNA modifications and cancer
Guangzhou Medical University
2021-2024
Third Affiliated Hospital of Guangzhou Medical University
2021-2024
Jilin Medical University
2016-2021
Jilin University
2021
The purified total sterols and β-sitosterol extracted from Sargassum horneri were evaluated for their antidepressant-like activity using the forced swim test (FST) tail suspension (TST) in mice. Total significantly reduced immobility time FST TST. administered orally 7 days at doses of 50, 100, 200 mg/kg, was intraperitoneally 10, 20, 30 mg/kg. had no effect on locomotor open field test. In addition, increased NE, 5-HT, metabolite 5-HIAA mouse brain, suggesting that may be mediated through...
Abstract Background MicroRNA (miR)-containing exosomes released by acute myeloid leukemia (AML) cells can be delivered into hematopoietic progenitor to suppress normal hematopoiesis. Herein, our study was performed evaluate the effect of exosomal miR-4532 secreted AML on hematopoiesis stem cells. Methods Firstly, differentially expressed miRs related were identified using microarray analysis. Subsequently, cell lines collected, and CD34 + HSCs isolated from healthy pregnant women. Then,...
There is growing evidence supporting the implications of exosomes-shuttled microRNAs (miRs) in phenotypes glioblastoma stem cells (GSCs), whilst role exosomal miR-27b-3p remains to be established. Herein, aim this study was investigate effect M2 tumor-associated macrophage (TAM)-derived on function GSCs. Clinical (GBM) specimens were obtained and GSCs M2-TAMs isolated by fluorescence-activated cell sorting (FACS), exosomes separated from M2-TAMs. It observed that M2-TAM-derived promoted...
Circular RNAs (circRNAs) are a group of noncoding derived from back-splicing events. CircRNA is reported to be involved in various tumor progressions, including glioma. Although there few reports circular participating gliomas, it still unclear whether regulate the occurrence gliomas. In our research, we found that expression circITGA7 glioma tissues and cells increased significantly. Knocking down can significantly inhibit proliferation reduce cell metastasis. Through analysis...
Background: In this study, we determine the potential roles and uncover regulatory mechanisms of circCCDC66 in regulating cell growth metastasis glioma. Methods: qRT-PCR was used to detect expressions gliomas tissues. The biological function glioma lines elucidated by functional experiments. Cell counting kit-8 transwell were effect on proliferation, migration invasion cells. Bioinformatics analysis applied reveal targets circCCDC66. Results: results showed overexpressed acted as an...
A series of tertiary sulphonamide derivatives were synthesised and evaluated for their antiproliferative activity against liver cancer cell lines (SNU-475, HepG-2, Bel-7402). Among these sulphonamides, compound 17a displayed the best anti-liver Bel-7402 cells with an IC50 value 0.32 μM. Compound could effectively inhibit tubulin polymerisation 1.27 Meanwhile, it selectively suppressed LSD1 63 nM. It also concentration-dependently inhibited migration cells. Importantly, exhibited potent...
Abstract Background Myelodysplastic neoplasms (MDS) are myeloid characterized by disordered differentiation of hematopoietic stem cells and a predisposition to acute leukemia (AML). The underline pathogenesis remains unclear. Methods In this study, the trajectory mechanisms leukemic transformation were explored through bioinformatics analysis single-cell RNA-Seq data from progenitor (HSPCs) in MDS patients. Results Among HSPC clusters, proportion common (CMP) was main cell cluster patients...
Periodic paralysis (PP) is an uncommon inherited disorder causing recurrent episodes of muscle weakness, with incidence 0.001%. Normokalemic periodic (NormoKPP) as the rarest subtype PP contains both familial and sporadic. Familial NormoKPP caused by p.M1592V mutation skeletal sodium channel alpha subunit (SCN4A) gene rarely reported. Only three pedigrees related to mutations in SCN4A have been previously We herein presented a family case associated mutation, which respiratory occurred...
ABSTRACT This study investigates platelet‐related subtypes in non‐small cell lung cancer (NSCLC) and seeks to identify genes associated with prognosis, focusing on the clinical significance of chloride ion channel gene BEST3. We utilised sequencing data from GEO, TCGA Xena platform, building a risk model based genetic features. GSE37745 served as training cohorts, while GSE50081, GSE13213, GSE30129 GSE42127 were validation cohorts. Immunotherapy datasets (GSE135222, TCGA‐SKCM) also analysed....
Abstract Background: Appendiceal malignant tumors are rare in the clinic, and incidence rate of gastrointestinal is only approximately 0.5%. Our aim to describe our experience with this disease increase knowledge on diagnosis treatment appendiceal tumors. Case presentation: We report case a 69-year-old woman who was admitted hospital due dyspepsia. The patient carrier hepatitis B virus, liver dysfunction diagnosed preoperatively. Abdominal enhanced computed tomography colonoscopy showed that...