A5059859214- Inflammatory Biomarkers in Disease Prognosis
- Extracellular vesicles in disease
- Radiomics and Machine Learning in Medical Imaging
- Cancer-related molecular mechanisms research
- Lung Cancer Diagnosis and Treatment
- Platelet Disorders and Treatments
- Management of metastatic bone disease
- Esophageal Cancer Research and Treatment
- Bacterial Identification and Susceptibility Testing
- AI in cancer detection
- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Blood groups and transfusion
- Mycobacterium research and diagnosis
- Sarcoma Diagnosis and Treatment
- Traditional Chinese Medicine Analysis
- COVID-19 diagnosis using AI
- Biomarkers in Disease Mechanisms
- Inflammasome and immune disorders
- Microbial Metabolism and Applications
- Venous Thromboembolism Diagnosis and Management
- Gastric Cancer Management and Outcomes
- Multiple and Secondary Primary Cancers
- Atherosclerosis and Cardiovascular Diseases
Sichuan Cancer Hospital
2019-2025
University of Electronic Science and Technology of China
2020-2025
Chengdu University of Traditional Chinese Medicine
2019
The aim of this study was to investigate the role platelet indicators in susceptibility ABO blood groups lung adenocarcinoma. This a multicenter retrospective cohort analysis. included 528 patients diagnosed with primary adenocarcinoma and randomly selected control group who were admitted Chengdu Fifth People's Hospital from January 2021 September 2023. Additionally, it 1452 Sichuan Cancer November 2013 May 2021. Platelet studied using an automated counter. determined by gel column method...
ABSTRACT Selective screening of the population based on NSCLC risk is an effective technique for minimising overdiagnosis and overtreatment. Platelets components can be used as liquid‐biopsy markers, potentially assessing NSCLC, which are easily deployed in clinical applications. Platelet RNA sequencing datasets were analysed to identify specific genes derived from patients healthy donors. Then, expressions selected gene validated a trial. Not only availability differentiating donors but...
The emergence of resistant Candida albicans has made clinical fluconazole (FLC) treatment difficult. Improving sensitivity to FLC is an effective way treat isolates. Berberine hydrochloride (BBH) a commonly-used traditional Chinese medicine with antimicrobial effects, especially in We investigated the molecular mechanisms underlying BBH and synergism on biofilm-positive FLC-resistant C. inhibition. Checkerboard microdilution assays time-kill showed strong synergistic effect between isolates,...
It has been proved that Raman spectral intensities could be used to diagnose lung cancer patients. However, the application of spectroscopy in identifying patients with pulmonary nodules was barely studied. In this study, we revealed spectra serum samples from healthy participants and benign malignant were significantly different. A support vector machine (SVM) model developed for classification wave points, according ANOVA test results. got a good performance median area under curve (AUC)...
Objectives: As the pulmonary nodules were hard to be discriminated as benignancy or malignancy only based on imageology, a prospective and observational real-world research was devoted develop validate predictive model for managing diagnostic challenge. Methods: This study started in 2018, constructed using eXtreme Gradient Boosting (XGBoost) computed tomographic, clinical, platelet data of all eligible patients. And evaluated compared with other common models ROC curves, continuous net...
Hepatocellular carcinoma (HCC) ranks third in the cause of death due to cancer.Circular RNA circSEC24 Homolog A (circSEC24A) has been uncovered be upregulated liver cancer.However, function circSEC24A HCC is indistinct.We analyzed microarray datasets GSE78520 and GSE94508 search for differentially expressed circRNAs associated with HCC.Expression circSEC24A, microRNA (miR)-455-3p, protein phosphatase, Mg2+/Mn2+ dependent 1F (PPM1F) mRNA was detected by quantitative real-time polymerase chain...
Tumor-educated platelets (TEPs) have been widely reported to promising application potential; nonetheless, platelet isolation from peripheral blood is an important but neglected step in TEPs research for platelet-based liquid biopsy. In this article, we discussed some common influence factors isolation. To investigate the involved isolation, a prospective multicenter study was conducted on healthy Han Chinese adults (18 79 years of age). A total 208 individuals were included final...
Many studies in recent years have demonstrated that some messenger RNA (mRNA) platelets can be used as biomarkers for the diagnosis of pan-cancer. The quantitative real-time polymerase chain reaction (RT-qPCR) molecular technique is most commonly to determine mRNA expression changes platelets. Accurate and reliable relative RT-qPCR highly dependent on reference genes. However, there no study validate gene Given genes altered certain conditions, selecting verifying suitable pan-cancer...
Abstract Objectives This study aimed to evaluate the prognostic significance of postoperative Creatine Kinase type M and B (CK-MB) total (CK) ratio (CK-MB/CK) in colorectal cancer (CRC) patients after radical resection. Methods was a single-center retrospective cohort analysis. Subjects were stage I-III CRC hospitalized Sichuan Cancer Hospital from January 2017 May 2021. Patients divided into abnormal group normal according whether CK-MB/CK surgery. Through comparative analysis clinical...
Small cell lung cancer (SCLC) is characterized by high invasion rates, rapid progression, and poor prognoses. Thus, identifying SCLC patients at risk of progression death critical to improve long-term survival. In this study, the aspartate transaminase-to-albumin ratio (ATAR) was examined as a prognostic factor for patients.
<title>Abstract</title> Background While the PRP (platelet-rich plasma) method was most widely used in tumor-educated platelets (TEPs) research, there were still peripheral blood unextracted which are whose histology and function currently alien. Objectives To prove existed, to explore correlation of with lung cancer progression. Methods A second centrifugation step establish a modified approach, compared based on PRR (platelet recovery rate). Sequencing analysis platelets. Results The...
<title>Abstract</title> Objective The aim of this study was to investigate the role platelet indicators in susceptibility ABO blood groups lung adenocarcinoma. Methods This a multicenter retrospective cohort analysis. included 528 patients diagnosed with primary adenocarcinoma and randomly selected benign who were admitted Chengdu Fifth People’s Hospital from January 2021 September 2023. Additionally, it 1452 Sichuan Cancer November 2013 May 2021. Platelet studied using an automated counter....
Abstract Platelets are vital in many pathophysiological processes, yet there is a lack of comprehensive resource dedicated specifically to platelet research. To fill this gap, we have developed PlateletBase, knowledge base aimed at enhancing the understanding and study platelets related diseases. Our team retrieved information from various public databases, extracting analyzing RNA-seq data 3,711 samples across 41 different conditions available on NCBI. PlateletBase offers six analytical...
ABSTRACT This study investigates platelet‐related subtypes in non‐small cell lung cancer (NSCLC) and seeks to identify genes associated with prognosis, focusing on the clinical significance of chloride ion channel gene BEST3. We utilised sequencing data from GEO, TCGA Xena platform, building a risk model based genetic features. GSE37745 served as training cohorts, while GSE50081, GSE13213, GSE30129 GSE42127 were validation cohorts. Immunotherapy datasets (GSE135222, TCGA‐SKCM) also analysed....
Gram-negative bacteremia (GNB) is a common complication in malignant patients. Identifying risk factors and developing prognostic model for GNB might improve the survival rate. In this observational real-world study, we retrospectively analyzed outcomes of Multivariable regression was used to identify incidence GNB, while Cox analysis performed significant factors. A constructed based on presented nomogram. ROC curves, calibration plots, Kaplan-Meier were estimate model. It comprised 1004...
Background: Esophageal squamous cell cancer (ESCC) is a disease with male predominance. Accordingly, the applicability of prognostic indicators values previously set for general population ESCC has not been reported determining physical state in females. Methods: Patients were pooled from 2009 to 2017 at Sichuan Cancer Hospital. We determined differences nutritional and inflammatory between gender by sex-stratified survival analysis all cohorts (n = 2,660) matching 483 pairs) separately....
Background: Staphylococcus epidermidis causes prosthetic valve endocarditis, urinary tract infection, and implant-related infections. These are difficult to treat often due drug resistance, particularly because S. biofilms inherently resistant most antibiotics. Salvia miltiorrhiza is a kind of sichuan-specific medicinal herb, has effective ingredients, such as cryptotanshinone. Cryptotanshinone was demonstrated have anti-microbial properties no resistance. Objectives: The current study...
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<title>Abstract</title> Objectives: This study aimed to evaluate the prognostic significance of postoperative Creatine Kinase (CK)-MB total-CK ratio (CK-MB/CK) in colorectal cancer (CRC) patients after radical resection. Methods: was a single-center retrospective cohort analysis. Subjects were stage I-III CRC hospitalized Sichuan Cancer Hospital from January 2017 May 2021. The overall survival (OS) and disease-free rate (DFS) analyzed between two groups according serum CK-MB/CK levels...