A5051349798- Soil Carbon and Nitrogen Dynamics
- Crop Yield and Soil Fertility
- Irrigation Practices and Water Management
- Microbial Community Ecology and Physiology
- Plant nutrient uptake and metabolism
- Nanoplatforms for cancer theranostics
- Plant Water Relations and Carbon Dynamics
- Nanoparticle-Based Drug Delivery
- Agronomic Practices and Intercropping Systems
- Rice Cultivation and Yield Improvement
- Legume Nitrogen Fixing Symbiosis
- Plant responses to water stress
- Plant Molecular Biology Research
- Medical Imaging Techniques and Applications
- Soil and Water Nutrient Dynamics
- Fractional Differential Equations Solutions
- Photoacoustic and Ultrasonic Imaging
- Plant Stress Responses and Tolerance
- Cancer, Hypoxia, and Metabolism
- S100 Proteins and Annexins
- Genetic Mapping and Diversity in Plants and Animals
- Mycorrhizal Fungi and Plant Interactions
- Radiopharmaceutical Chemistry and Applications
- Cancer Research and Treatments
- Plant Micronutrient Interactions and Effects
Northwest A&F University
2016-2025
The University of Texas MD Anderson Cancer Center
2015-2025
China National Rice Research Institute
2018-2025
People's Hospital of Kaizhou District
2019-2024
Shanxi Medical University
2021-2024
Chongqing Jiaotong University
2024
Second Hospital of Shanxi Medical University
2021-2024
TianjinSino-German University of Applied Sciences
2024
Guangdong Baiyun University
2022-2023
Chengdu University of Traditional Chinese Medicine
2021-2023
Plasmacytoid dendritic cells (pDCs) produce copious type I interferon (IFN) upon sensing nucleic acids through Toll-like receptor (TLR) 7 and TLR9. Uncontrolled pDC activation IFN production are implicated in lymphopenia autoimmune diseases; therefore, a mechanism controlling is essential. Human pDCs specifically express an orphan receptor, immunoglobulin-like transcript (ILT7). Here, we discovered ILT7 ligand expressed by human cell lines identified it as bone marrow stromal antigen 2...
Abstract Immunotherapy has only limited efficacy against pancreatic ductal adenocarcinoma (PDAC) due to the presence of an immunosuppressive tumor-associated stroma. Here, we demonstrate effective modulation that stroma by irreversible electroporation (IRE), a local ablation technique received regulatory approval in United States. IRE induces immunogenic cell death, activates dendritic cells, and alleviates stroma-induced immunosuppression without depleting tumor-restraining collagen. The...
The purpose of this study was to compare the binding affinity and selective targeting aptamer- antibody-coated hollow gold nanospheres (HAuNS) targeted epidermal growth factor receptors (EGFR). EGFR-targeting aptamers were conjugated HAuNS (apt-HAuNS) by attaching a thiol-terminated single-stranded DNA then adding complementary RNA EGFR. Apt-HAuNS characterized in terms size, surface charge, absorption, number per particle. vivo pharmacokinetics, biodistribution, micro-SPECT/CT imaging...
Conservation tillage is an extensively used agricultural practice in northern China that alters soil texture and nutrient conditions, causing changes the microbial community. However, how conservation affects rhizosphere bulk fungal communities during plant growth remains unclear. The present study investigated effect of long-term (six years) (chisel plough, zero) conventional (plow) wheat on community, using high-throughput sequencing internal transcribed spacer (ITS) gene quantitative PCR....
We report the synthesis of PEG-coated, core-cross-linked polymeric micelles (CCPMs) derived from an amine-terminated amphiphilic block copolymer, poly(PEG-methacrylate)-b-poly(triethoxysilyl propylmethacrylate). The copolymer self-assembled to form micellar nanoparticles, and a Cy-7-like near-infrared fluorescence (NIRF) dye was entrapped in core bearing reactive ethoxysilane functional groups through subsequent sol−gel process. fluorescent signal CCPMs on molar basis 16-fold brighter than...
There is much interest in the development of a nanoscale drug delivery system with MRI visibility to optimize efficiency and therapeutic efficacy under image guidance. Here we report on successful fabrication micelles based biodegradable poly(l-glutamic acid)-b-polylactide (PG-b-PLA) block copolymer paramagnetic Gd3+ ions chelated their shell. PG-b-PLA was synthesized by sequential polymerization reactions: anionic l-lactide followed ring-opening benzyl glutamate N-carboxylic anhydride. The...
Many new drugs have low aqueous solubility and high therapeutic efficacy. Paclitaxel (PTX) is a classic example of this type compound. Here we show that extremely small (<40 nm) hydrophilic carbon clusters (HCCs) are PEGylated (PEG-HCCs) effective drug delivery vehicles when simply mixed with paclitaxel. This formulation PTX sequestered in PEG-HCCs (PTX/PEG-HCCs) stable for at least 20 weeks. The PTX/PEG-HCCs was as clinical reducing tumor volumes an orthotopic murine model oral squamous...
Drought is a multifaceted stress condition that inhibits crop growth. Seed germination one of the critical and sensitive stages plants, its process inhibited or even entirely prevented by drought. Polyamines (PAs) are closely associated with plant resistance to drought seed germination. However, little known about effect PA on wheat under stress. This study investigated involvement PAs in regulating Six genotypes differing were used, endogenous levels measured during different water...