A5028672973- Genetic and phenotypic traits in livestock
- Lung Cancer Diagnosis and Treatment
- Advanced Proteomics Techniques and Applications
- Metabolomics and Mass Spectrometry Studies
- RNA modifications and cancer
- Animal Nutrition and Physiology
- Genetic Mapping and Diversity in Plants and Animals
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Peptidase Inhibition and Analysis
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Mass Spectrometry Techniques and Applications
- Cancer-related molecular mechanisms research
- Immune cells in cancer
- Machine Learning in Bioinformatics
- Hedgehog Signaling Pathway Studies
- Radiomics and Machine Learning in Medical Imaging
- Redox biology and oxidative stress
- Zoonotic diseases and public health
- Circular RNAs in diseases
- Antioxidant Activity and Oxidative Stress
- Photodynamic Therapy Research Studies
- Algebraic structures and combinatorial models
- Target Tracking and Data Fusion in Sensor Networks
Peking University
2024
PLA Army Engineering University
2024
Shanghai Sixth People's Hospital
2024
China Agricultural University
2019-2024
Northwest University
2020-2024
Second Affiliated Hospital of Xi'an Jiaotong University
2008-2020
Hebei Normal University
2019
Xi'an Jiaotong University
2008
Egg-laying performance is of great economic importance in poultry, but the underlying genetic mechanisms are still elusive. In this work, we conduct a multi-omics and multi-tissue integrative study hens with distinct egg production, to detect hub candidate genes construct molecular networks contributing egg-laying phenotypic differences. We identifiy three as facilitators: TFPI2, which promotes GnRH secretion hypothalamic neuron cells; CAMK2D, FSHβ LHβ pituitary OSTN, granulosa cell...
The advanced intercross line (AIL) that is created by successive generations of pseudo-random mating after the F2 generation a valuable resource, especially in agricultural livestock and poultry species, because it improves precision quantitative trait loci (QTL) mapping compared with traditional association populations introducing more recombination events. growth traits broilers have significant economic value chicken industry, many QTLs affecting been identified, on chromosomes 1, 4, 27,...
Introduction: Non-small cell lung cancer (NSCLC) is the most common malignant tumor, and its recurrence metastasis are main causes of death. Recently, there evidence that tumor derived exosomes play an important role in occurrence development NSCLC. Objectiveâs methods: First, expression miR-185-5p RAB35 NSCLC tissues, paracancerous lines normal human bronchial epithelial line was detected. Then, a series gain-and loss-of-function assays were performed to validate effects or on A549 H2170...
Abstract miR-195-5p has been widely explored in various cancers and is considered as a tumor-suppressive microRNA. However, its roles human lung cancer pathogenesis are not fully elucidated. In this study, we aimed to explore how involved malignant behaviors of adenocarcinoma (LUAD) cells. expression was examined the tumor tissues patients with LUAD cell lines including A549 PC-9. Thioredoxin reductase 2 (TrxR2) predicted be an mRNA target using online tools validated by Dual-Luciferase...
Abstract Background The purpose of this study is to discover potential biomarkers in serum for the detection small cell lung cancer (SCLC). Methods 74 samples including 30 from SCLC patients and 44 healthy controls were analyzed using ClinProt system combined with matrix-assisted laser desorption/ionization time-of-flight masss spectrometry (MALDI-TOF-MS). software genetic algorithm analysis selected a panel markers that most efficiently predicted which had SCLC. Results diagnostic pattern 5...
Using small sets of ancestry informative markers (AIMs) constitutes a cost-effective method to accurately estimate the proportions individuals. This study aimed generate and effective number AIMs from ∼60 K single nucleotide polymorphism (SNP) data porcine three [East China pig (ECHP), South (SCHP), European commercial (EUCP)] Asian breeds domestic breeds. A total 186 samples 10 pure were divided into groups: ECHP, SCHP, EUCP. these one-vs.-rest SVM classifier, we found that using only seven...
Abstract There is generally one standard reference sequence for each species. When extensive variations exist in other breeds of the species, it can lead to ambiguous alignment and inaccurate variant calling and, turn, compromise accuracy downstream analysis. Here, with help FPGA hardware platform, we present a method that generates an alternative via iterative strategy improve read are genetically distant breed. Compared published genomes, by using sequences built, mapping rates Chinese...
Polycystin-2(PC2) composed of PKD2 gene encoding a transmembrane protein plays an important role in kidney disease, but the which lipopolysaccharide (LPS)-induced acute lung injury (ALI) was unclear. We overexpressed PC2 epithelial cell vitro and vivo examined inflammatory response induced by LPS vivo.We demonstrated that overexpression significantly decreased production factors TNF-α, IL-1β, IL-6 LPS-treated cells. Moreover, pre-treatment 3-Methyladenine (3-MA), autophagy inhibitor,...
Let K denote an algebraically closed field of characteristic zero and let d0,e1,e2 be some scalars in K. By the Racah algebra A associated with d0,e1,e2, we mean most general quadratic two independent generators x,y, which possesses presentations ladder relations. In this paper, classify finite-dimensional irreducible A-modules up to isomorphism by using theory Leonard pairs. For a given A-module V dimension d + 1, give its corresponding classes pairs on that have type.
支气管内超声(endobronchial ultrasound, EBUS)技 术于1992年首次应用于临床。随着超声及相关技术的 进步,EBUS仪器性能日臻完善,操作技术日渐成熟, 逐步建立了气道和纵隔的超声声像图谱,使支气管镜的 检查范围从管腔内扩展到了管腔外,明显提高了支气管 镜检查的效率,因而在呼吸系统疾病中的应用越来越广 泛,迄今已成为胸部肿瘤诊断和治疗中最有前景的微创 技术之一。 微型超声探头是EBUS最主要的组成部分。探头 外带水囊使探头能更好地接触气道粘膜,获得更清晰 的超声图像。根据超声探头的不同,将EBUS分为两种 类型。一种为早期的EBUS,带直径2 mm的径向探头 (radial probe, RP),分辨率为0.1 mm,可通过活检通 道进入气道内进行360°成像扫描,可清楚地显示气道 壁及其周围组织的细微结构,可显示深达5 cm的肺门 及纵隔淋巴结,主要用于检查肺外周(亚段以下支气 管)病变、判断肿瘤浸润管壁的深度、鉴别气道壁内 病变的良恶性,但该探头不能进行实时监控下病灶活 检。另一种EBUS为近年开发的凸面探头(convex...
This study was to investigate the differential mitochondrial protein expressions in human lung adenocarcinoma and provide preliminary data for further exploration of carcinogenic mechanism.Total proteins A549 16HBE mitochondria were extracted through 2D polyacrylamide gel electrophoresis (2-DE). The identified by liquid chromatography-tandem mass spectrometry (LC-MS/MS) confirmed Western blot, immunoelectron microscopy immunohistochemistry (IHC) cells as well tissues.A total 41...
There is heterogeneity in cancer patients’ responses to immune checkpoint inhibitors (ICIs), including hyperprogression, which very rapid tumor progression following immunotherapy, and pseudoprogression, an initial increase followed by a decrease burden or the number of lesions. This complicates clinical decisions because either premature withdrawal treatment prolonged ineffective harms patients. We presented two patients treated with ICIs heterogeneous responses. One patient had Merkel cell...
It focused on the antiviral immune regulation of biofilm-localized protein kinase Dbf2p-related 1 (NDR1) in viral pneumonia. Mouse alveolar monocyte RAW264.7 was used as blank control, and pneumonia cell model prepared by infecting cells with respiratory syncytial virus (RSV). NDR1 overexpression vector siRNA interference sequences were synthesized, overexpression/silence fabricated. About 50 ng/mL interleukin 17 (IL-17) given to stimulate. Enzyme-linked immunosorbent assay (ELISA),...