A5103245714- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- RNA modifications and cancer
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Radiomics and Machine Learning in Medical Imaging
- Ferroptosis and cancer prognosis
- Cytokine Signaling Pathways and Interactions
- Machine Learning in Bioinformatics
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
Shaanxi Provincial People's Hospital
2017-2025
Shanxi Medical University
2014-2020
Shaanxi Provincial People's Hospital
2014-2020
Xi'an Jiaotong University
2009
BackgroundMicroRNA-17-5p (miR-17-5p) plays a pivotal role in the tumorigenesis and progression of non-small cell lung cancer (NSCLC) by regulating its target genes. Advances molecular biology highlight importance long non-coding RNAs (lncRNAs) cancer, yet mechanistic interactions between miR-17-5p lncRNAs NSCLC remain underexplored.ObjectiveThis study investigated regulatory interplay lncRNA-FGD5-AS1 evaluated their potential as targets for therapy.MethodsA comprehensive set technologies,...
Six-transmembrane epithelial antigen of prostate-1 (STEAP1) is a relatively newly identified gene target from prostate cancer, breast and gastric cancer. However, functions STEAP1 in lung adenocarcinoma (LUAD) are still unknown. In the present study, we explored molecular cellular mechanisms LUAD. Western blot Q-PCR were conducted to detect protein mRNA expressions respectively. The cell proliferation was tested by CCK8 assay. effects on metastasis epithelial-mesenchymal transition (EMT)...
Abstract miR-195-5p has been widely explored in various cancers and is considered as a tumor-suppressive microRNA. However, its roles human lung cancer pathogenesis are not fully elucidated. In this study, we aimed to explore how involved malignant behaviors of adenocarcinoma (LUAD) cells. expression was examined the tumor tissues patients with LUAD cell lines including A549 PC-9. Thioredoxin reductase 2 (TrxR2) predicted be an mRNA target using online tools validated by Dual-Luciferase...
To evaluate the diagnosis model of serum tumor biomarker and several clinical features diagnose classification for lung cancer, solid protein chip technology (C-12) was used to detect biomarkers SF, CEA, CA242, NSE, CA125, CA19-9 CA15-3 in tumors benign disease elderly cancer patients were collected. Set up a discriminating analysis as function diagnostic sub-type discrimination. In combination 2 obvious indicators markers, it is possible provide tool cancer. With help mathematic model,...
Lung cancer is one of the malignant tumors with serious health consequences for people all over world.Non-small-cell lung cancer(NSCLC)is most common type cancer, making up 80% to 85% cases.As a result low rates early detection, more than 70% patients, many them elderly are in late stages(Ⅲ-Ⅳ)at time diagnosis, and cannot be effectively treated surgery.First-line chemotherapy critical treatment patients advanced or recurrent cancer.Elderly show decreased tolerance side effects toxicities...
Objective To analyse the clinical effect and safety of Alimta (Pemetrexed) combined with cisplatin treatment (PP) on elderly patients non small cell lung cancer (NSCLC). Methods We retrospectively analyzed data 40 cases NSCLC treated Pemetrexed for first-line chemotherapy, 24 them continually received single maintenance (PP+ C). Then we compared results 35 in non-Pemetrexed regimen (control group) 26 best supportive care (BSC) same period. The adverse reactions short-term efficacy...