A5100668400- Gastric Cancer Management and Outcomes
- Intraperitoneal and Appendiceal Malignancies
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Bone Tumor Diagnosis and Treatments
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Appendicitis Diagnosis and Management
- Hepatocellular Carcinoma Treatment and Prognosis
- Ferroptosis and cancer prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Acute Kidney Injury Research
- Sarcoma Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Organ Transplantation Techniques and Outcomes
- Oral and Maxillofacial Pathology
- Cancer-related molecular mechanisms research
- Cancer Diagnosis and Treatment
- Liver Disease and Transplantation
- Amoebic Infections and Treatments
- Diabetes and associated disorders
- FOXO transcription factor regulation
- Pancreatic function and diabetes
- Diabetes, Cardiovascular Risks, and Lipoproteins
Jiujiang University
2020-2024
First Affiliated Hospital of Jiangxi Medical College
2024
Nanchang University
2024
Fudan University
2015-2022
First Hospital of China Medical University
2008-2021
Peking University
2021
Qingdao University
2021
Peking University First Hospital
2021
China Medical University
2008-2020
Xijing Hospital
2015-2020
Lung squamous cell carcinoma (LSCC) is the most common subtype of non-small lung cancer. Immunotherapy has become an effective treatment in recent years, while patients showed different responses to current treatment. It vital identify potential immunogenomic signatures predict patient' prognosis. The expression profiles LSCC with clinical information were downloaded from TCGA database. Differentially expressed immune-related genes (IRGs) extracted using edgeR algorithm, and functional...
Abstract In this study, we determined the risk factors for acute kidney injury (AKI) following orthotopic liver transplantation (OLT) in China. We collected 5074 donation after cardiac death (DCD) OLT recipients who underwent surgery between January 1, 2010, and December 31, 2015, 86 academic hospitals or transplant centers Univariate multivariate analyses were used to investigate criticality of donor, graft, recipient variables development post-OLT AKI. all, 4482 patients included (median...
Abstract Background Curing locally advanced gastric cancer through surgery alone is difficult. Adjuvant and neoadjuvant chemotherapy bring potential benefits to more patients with based on several clinical trials. According phase II studies guidelines, SOX regimen as efficient. However, the optimal duration of has not been established. In this study, we will evaluate efficacy safety different cycles for cancer. Methods RESONANCE-II trial a prospective, multicenter, randomized, controlled III...
Abstract Gastric cancer is still one of the most common and deadly malignancies in world. Not all patients could benefit from chemotherapy or chemoradiotherapy due to tumor heterogeneity. Therefore, identifying different subgroups an important trend for obtaining more effective responses. However, few molecular classifications associated with chemosensitivity are based on immune–risk status. In this study, we obtained six key immune–related genes. Using these genes, constructed a model...
Pancreatic islet transplantation is a promising treatment for type 1 diabetes (T1D). Interleukin-35 (IL-35) recently discovered cytokine that exhibits potent immunosuppressive functions. However, the role of IL-35 in transplant rejection remains to be elucidated. In this study, we isolated cells BALB/c mouse and purified CD4+ T cell subsets C57BL/6 mouse. The model was established vitro by co-culture cells. (20 ng/ml) administered every other day. Following co-culture, function Treg/Th17...
The aim of the present study was to observe protective effect grape seed proanthocyanidins (GSPs) against endoplasmic reticulum (ER) stress‑mediated apoptosis caused by hypoxia/reoxygenation (H/R) injury in H9C2 cardiomyocytes along with its potential mechanisms. underwent hypoxia for 3 h followed reoxygenation h. Different doses GSPs (50, 100 and 200 µg/ml) were administered 30 min before hypoxia. Cell viability assessed, as well lactic dehydrogenase (LDH) activity, cell rate, expression...
Abstract Background Prognostic indicators in lung adenocarcinoma (LUAD) have been seeking under database analysis, and remarkable advance is on the way. Methods This study calculated scores of stromal immune components tumor microenvironment (TME) 551 LUAD samples using ESTIMATE algorithm The Cancer Genome Atlas (TCGA) database. R package ''limma'' was used to selected differentially expressed genes (DEG). We analyzed DEGs by means Gene Ontology (GO) analysis Kyoto Encyclopedia Genes Genomes...
Skull base chordoma is a rare tumor arising from embryonic remnants of the notochord with invasive potential. Due to destruction osseous landmarks and invasion surrounding structures, surgical resection challenging. The authors explored clinical value multimodal neuronavigation system in skull using neuroendoscope. Between January 2012 2016, utilized neuroendoscopy excise 93 patients. performed 45 operations assisted by (neuronavigation group) 48 without intraoperative imaging guidance...
Introduction: Non-Small-Cell Lung Cancer (NSCLC) represents the leading cause of cancer deaths in world. We previously found that daidzein, one key bioactivators soy isoflavone, can inhibit NSCLC cell proliferation and migration, while molecular mechanisms daidzein remain unclear. Methods: developed an nude mouse model using H1299 cells treated mice with (30 mg/kg/day). Mass spectrometry analysis tumor tissues from daidzein-treated identified 601 differentially expressed proteins (DEPs)...
Background . Pseudomyxoma peritonei (PMP) is a rare neoplasm involving the peritoneum. Most PMPs are low-grade appendicular mucinous neoplasms (LAMNs). There have been no reports of PMP originating from transverse colonic adenocarcinoma and causing metastatic adenocarcinoma. Case Presentation We report 46-year-old woman who presented with right abdominal mass more than 4-month duration. Transverse adenocarcinoma, PMP, ovarian were diagnosed. The patient’s diet was normal, she had pain or...
The aim of our study was to observe the occurrence rate and morphological characteristics Infra-Lamina ridge (ILR) in Chinese population provide a comprehensive reference for its clinical implication.Vertebrae columns 82 sets adult skeletons were collected.The shape ILR classified into three types; it different sides sexes counted.The length, width, thickness measured using caliper with 0.02 mm accuracy.The usually found occur from C7 L5, frequency higher T8 12, highest at T10-being up...
Abstract Background: HPV16 is the most common infection subtype, among which E6 and E7 proteins are carcinogenic proteins. Our previous studies found that regulated expression of GLUT1 through multiple molecular signaling pathways in lung cancer. However, whether they can regulate glucose uptake underlying mechanism has not been identified. Methods: The modulating effects or E7, NDRG2, β-catenin, were detected by double directional genetic manipulations cancer cell lines; immunofluorescence...
49 Background: According to WHO estimation, > 400,000 new cases of gastric cancer have occurred in 2012 China, making it the second most common malignancy country. However, little is known about epidemiological data China. This analysis aimed evaluate clinicopathological and socioeconomic characteristics Chinese patients with non-mGC. Methods: EVIDENCE was a prospective registry study. 2,600 newly diagnosed from 85 hospitals across China were planned be enrolled into this Patients who...
Objective: To explore the effect of laparoscopy on cancer cells and expressions adhesion molecules (ICAMâ1, CD44v6 & integrin β1) in peritoneal tissue abdominal rinse patients with colorectal carcinoma (CC). Methods: A total 65 CC cases undergoing radical resection at our hospital were analyzed. They divided into two groups LAP (laparoscopy, n=35) OP (open surgery, n=30). Peritoneal tissues collected incision beyond .Also was before tumor abdomen closure. The (ICAMâ1 ,CD44v6 beta 1)...