A5100392235- Neuroscience of respiration and sleep
- Obstructive Sleep Apnea Research
- Heart Rate Variability and Autonomic Control
- Regulation of Appetite and Obesity
- Receptor Mechanisms and Signaling
- High Altitude and Hypoxia
- Biochemical Analysis and Sensing Techniques
- Sleep and Wakefulness Research
- melanin and skin pigmentation
- Plant-derived Lignans Synthesis and Bioactivity
- Heme Oxygenase-1 and Carbon Monoxide
- Neuroendocrine regulation and behavior
- Vestibular and auditory disorders
- Biological Activity of Diterpenoids and Biflavonoids
- Respiratory Support and Mechanisms
- Neonatal and fetal brain pathology
- Cancer, Hypoxia, and Metabolism
- Neuropeptides and Animal Physiology
- Neonatal Respiratory Health Research
- Pharmacology and Obesity Treatment
- Neurobiology and Insect Physiology Research
- Endoplasmic Reticulum Stress and Disease
- Bioactive natural compounds
- Neuroscience and Neuropharmacology Research
- Renin-Angiotensin System Studies
McMaster University
2024
Brigham and Women's Hospital
2023
Harvard University
2023
Circadian (United States)
2023
First Hospital of China Medical University
2010-2023
China Medical University
2007-2023
University of Florida
2022
Auburn University
2016-2018
Neurological Research Institute
2017
Baylor College of Medicine
2017
The paraventricular nucleus (PVN) of the hypothalamus is known to be an important site integration in central nervous system for sympathetic outflow. ANG II and nitric oxide (NO) play role regulation nerve activity. purpose present study was examine how interaction between NO within PVN affects outflow rats. Renal discharge (RSND), arterial blood pressure (AP), heart rate (HR) were measured response administration N G -monomethyl-l-arginine (L-NMMA) into PVN. Microinjection (0.05, 0.5, 1.0...
Abstract Faster acclimatization to high altitude upon re-ascent is seen in humans; however, the molecular basis for this enhanced adaptive response unknown. We report that healthy lowlanders, plasma adenosine levels are rapidly induced by initial ascent and achieved even higher re-ascent, a feature positively associated with quicker acclimatization. Erythrocyte equilibrative nucleoside transporter 1 (eENT1) reduced humans at mice under hypoxia. eENT1 deletion allows rapid accumulation of...
Identification of MCHR1 antagonists with a preclinical safety profile to support clinical evaluation as antiobesity agents has been challenge. Our finding that basic moiety is not required for achieve high affinity allowed us explore structures less prone off-target activities such hERG inhibition. We report the SAR evolution hydroxylated thienopyrimidinone ethers culminating in identification 27 (BMS-819881), which entered obesity trials phosphate ester prodrug 35 (BMS-830216).
1 Alterations in the paraventricular nucleus (PVN) are reported to be involved sympathetic overactivity chronic heart failure (CHF). Inhibitory inputs into PVN contribute outflow. The aim of present study was comparatively determine role GABA mechanisms tonic control cardiovascular activity anaesthetized sham and CHF rats. 2 model induced by coronary artery ligation. Unilateral microinjection GABAA receptor agonist muscimol (0.1–0.8 nmol/200 nL) or GABAB baclofen (0.25–2.0 produced similar,...
Abstract The aim of the present study was to determine role GABA A and B receptors in paraventricular nucleus (PVN) regulating cardiac sympathetic afferent reflex (CSAR). Under urethane (800 mg/kg) α‐chloralose (40 anesthesia, renal nerve activity (RSNA), mean arterial pressure (MAP) heart rate (HR) were recorded sinoaortic‐denervated cervical‐vagotomized rats. CSAR evaluated based response RSNA epicardial application capsaicin (0.3 nmol) or bradykinin (1 nmol). Bilateral PVN microinjection...
Genioglossus activity is greater during wakefulness but decreases to a weaker state sleep in obstructive apnea syndrome (OSAS) patients, compared healthy subjects. Previous studies suggested that the corticomotor control of genioglossus was modified OSAS patients. Intermittent hypoxia (IH), typical pathophysiological change OSAS, can induce facilitation. The serotonergic neurons raphe dorsal (DRN) and magnus nuclei (RMg) are responsive play important roles genioglossus. However, it remains...
The modulation of activity the upper airway dilator and respiratory muscles plays a key role in regulation ventilation, but little is known about link between their neuromuscular activation processes vivo. This study investigated genioglossus diaphragm responses to transcranial magnetic stimulation applied different facilitatory conditions. amplitude latency motor-evoked potential intensity threshold leading motor response (motor threshold) were recorded with at vertex anterolateral area 13...
The aim of the present study was to observe protective effect grape seed proanthocyanidins (GSPs) against endoplasmic reticulum (ER) stress‑mediated apoptosis caused by hypoxia/reoxygenation (H/R) injury in H9C2 cardiomyocytes along with its potential mechanisms. underwent hypoxia for 3 h followed reoxygenation h. Different doses GSPs (50, 100 and 200 µg/ml) were administered 30 min before hypoxia. Cell viability assessed, as well lactic dehydrogenase (LDH) activity, cell rate, expression...
Subscription RequiredScientific InvestigationsAssociation of cortical arousals with sleep-disordered breathing events Kirsi-Marja Zitting, PhD, Brandon J. Lockyer, BA, RPSGT, Ali Azarbarzin, Scott A. Sands, Wei Wang, Andrew Wellman, MD, Stuart F. Quan, MD PhD , RPSGT Published Online:January 28, 2023https://doi.org/10.5664/jcsm.10492
Neuromuscular compensation of the genioglossus muscle can be induced by chronic intermittent hypoxia (CIH) in obstructive sleep apnea to maintain upper airway stability. Noradrenergic activation hypoglossal nucleus plays a critical role central control genioglossus. However, it remains unknown whether norepinephrine takes part regulation during CIH. Adult male Wistar rats (n = 32) were studied explore influence noradrenergic on at different stages The divided into four groups: normal or...
Abstract Hypoglossal motoneurons innervate genioglossus muscle, the contraction of which is critical in maintenance upper airway patency patients with obstructive sleep apnea. As a potassium channel distributed hypoglossal motoneurons, TWIK‐related acid‐sensitive K+ channel‐1 (TASK‐1) could be inhibited by 5‐HT. This study aimed to investigate if TASK‐1 expression nucleus influenced chronic intermittent hypoxia (CIH) and 5‐HT 2A receptors antagonist. Two hundred twenty‐eight rats were...
The mechanical efficiency of upper airway (UA) muscles are pivotal in maintaining UA stability. We aimed to investigate if different tongue training approaches could differently induce signs neuroplastic the corticomotor pathways and stability changes. 36 Sprague-Dawley rats were trained daily for eight weeks lick an isotonic force-sensing disc at targeting forces using 30%-50% maximal achieved force (MALF) task (TTT) or set above 50%, 60%, 70% MALF progressively strength (TST). Corticomotor...
Obstructive sleep apnea (OSA) is characterized by the repetitive collapse of upper airway and chronic intermittent hypoxia (CIH) during sleep. It has been reported that CIH can increase EMG activity genioglossus in rats, which may be related to neuromuscular compensation OSA patients. This study aimed explore whether could induce long-term facilitation (LTF) corticomotor activity. 16 rats were divided into air group (n=8) (n=8). The was exposed for 4 weeks; subjected under identical...
Codeine is one of the opioids abuse that available by prescription, and fentanyl leading opioid drug abuse. Both codeine are µ-opioid agonists strong respiratory depressants. However, unlike fentanyl, also binds to nicotinic receptors. We hypothesized influence these drugs on stability breathing would differ due relative non-specificity codeine. Ten anesthetized, spontaneously adult cats were tracheotomized, EMG activity was recorded from inspiratory muscles. Dose responses (n=5, 0.1 - 10...