A5100755448- Dental Implant Techniques and Outcomes
- Gastric Cancer Management and Outcomes
- Winter Sports Injuries and Performance
- Reconstructive Facial Surgery Techniques
- Nasal Surgery and Airway Studies
- Cancer Genomics and Diagnostics
- Cardiac, Anesthesia and Surgical Outcomes
- Spinal Fractures and Fixation Techniques
- Pelvic and Acetabular Injuries
- EEG and Brain-Computer Interfaces
- Periodontal Regeneration and Treatments
- RNA modifications and cancer
- Reconstructive Surgery and Microvascular Techniques
- Acupuncture Treatment Research Studies
- Cancer Diagnosis and Treatment
- Obstructive Sleep Apnea Research
- Osteoarthritis Treatment and Mechanisms
- Medical Research and Treatments
- Prostate Cancer Treatment and Research
- Spine and Intervertebral Disc Pathology
- Bladder and Urothelial Cancer Treatments
- Platelet Disorders and Treatments
- Intraperitoneal and Appendiceal Malignancies
- Berberine and alkaloids research
- Pediatric health and respiratory diseases
Fudan University
2025
Children's Hospital of Fudan University
2025
Nanjing University of Chinese Medicine
2024-2025
Shandong First Medical University
2024
Daqing Oilfield of CNPC
2024
Suizhou Central Hospital
2024
Daqing Oilfield General Hospital
2024
Chengdu University of Traditional Chinese Medicine
2024
Suzhou Traditional Chinese Medicine Hospital
2024
Shandong Provincial Hospital
2024
Tertiary lymphoid structures (TLS) in the tumor microenvironment (TME) are emerging solid-tumor indicators of prognosis and response to immunotherapy. Considering that tumorigenesis requires metabolic reprogramming subsequent TME remodeling, discovery TLS regulators is expected produce immunotherapeutic targets. To identify such regulators, we constructed a metabolism-focused sgRNA library performed an vivo CRISPR screening orthotopic lung mouse model. Combined with The Cancer Genome Atlas...
The study aims to develop an automatic sleep scoring method by fusing different polysomnography (PSG) signals and further investigate PSG signals' contribution the result. Eight combinations of four modalities signals, namely electroencephalogram (EEG), electrooculogram (EOG), electromyogram (EMG), electrocardiogram (ECG) were considered find optimal fusion signals. A total 232 features, covering statistical characters, frequency time-frequency fractal entropy characters nonlinear derived...
Aldo-keto reductase 1C3 (AKR1C3) plays a key role in tumor progression and chemotherapy resistance, particularly sorafenib-resistant hepatocellular carcinoma (HCC). Targeting AKR1C3 represents promising strategy to restore chemosensitivity resistant HCC. Previous research identified the lead compound S07-2005 through cascade virtual screening approach (AKR1C3 IC50 = 130 ± 30 nM, SI (selective index) > 77). Using cocrystal-guided drug design, was optimized adopt an "L"-shaped conformation...
ABSTRACT Background The free fibula flap has become popular for mandibular reconstruction. purpose of this study was to propose comprehensive functional assessments the donor site. Methods Thirty flaps mandible reconstruction were prospectively enrolled in study. Objective included isokinetic testing ankle joint, electromyographic examination superficial peroneal nerve (SPN), and preoperative postoperative foot scans. Patient Observer Scar Assessment Scale (POSAS) used subjectively assess...
We have explored the role of Chondromodulin-I (ChM-I) in chondrogenesis bone marrow-derived mesenchymal stem cells (BMSCs) 3-dimensional (3D) scaffold for cartilage tissue engineering. BMSCs Sprague Dawley (SD) rats were cultured on poly-(L-lactic acid) [PLLA] scaffolds with different pore sizes (80-200 μm, 200-450 μm) or without surface modification by chitosan. Cell viability, proliferation, and morphology measured using confocal microscope CCK-8 method. Untransfected BMSCs, expressing...
In reality, the remaining oil in ultra-high water cut period is highly dispersed, so a thorough investigation required to understand microscopic oil. This will directly influence technological direction and allow for countermeasures such as enhanced recovery (EOR). Therefore, this study aims investigate state, classification method utilization mechanism of late cut. To achieve this, based on mechanical was developed using displacement CT scan micro-scale flow simulation methods. Three...
Abstract Background The anterolateral thigh (ALT) free flap has been an extremely versatile flap. purpose of this study was to propose comprehensive functional assessments the donor site. Methods A total 33 ALT flaps were enrolled prospectively. Objective included isokinetic testing knee, and electromyographic examination lateral femoral cutaneous nerve (LFCN). Patient Observer Scar Assessment Scale (POSAS) used subjectively assess donor‐site scar. Results On side, a significant decrease in...
Primary appendiceal adenocarcinoma with peritoneal pseudomyxoma (PPM) has a high recurrence rate and refractory to medical interventions such as repetitive debulking surgery systemic chemotherapy. Genome-based targeted therapy for cases not been well-documented. Here we present 63-years-old women, who was diagnosed recurrent mucinous of the appendix local invasions carcinomatosis, chemotherapy after surgery. We used regime developed using whole exome sequencing. Somatic mutations in genes...
// Lai Wei 1,* , Lizhi Wang Ziye Liu 1 Meiyi Weili Lu Dewei Zhao 2 Bin Yang Xuejun Kong 3 Yan Ding 2,3,4 and Zhiqiang Department of Otolaryngology, Affiliated Zhongshan Hospital Dalian University, Dalian, China The Institute for Translational Medicine, Pediatrics, Children's Boston, Harvard Medical School, MA, USA 4 Program Autism Research, Massachusetts General Hospital, * These authors have contributed equally to this work Correspondence to: Wang, email: Ding, Keywords : temporal bone...
<title>Abstract</title> Background Intervertebral disc degeneration (IDD) is one of the main factors leading to low back pain. However, its potential pathogenesis targets are poorly understood. Therefore, IDD must be further explored identify more appropriate treatment angles. Objective To investigate effects hypoxia-inducing factor-1α (HIF-1α)/BCL-2 interacting protein 3 (Bnip3)/vascular endothelial growth factor (VEGF) signaling axis on induced by inflammatory tumor necrosis factor-alpha...
The clinical applications of endoscope-assisted transoral release for irreducible atlantoaxial dislocations are limited. This study aimed to investigate the effect and prognostic factors traditional release, as well posterior reduction fixation, in treating dislocations.
Bone is one of the common sites metastasis in lung cancer. Pathological fractures femur significantly reduce patients' quality life and increase risk death. However, there still no consensus on optimal treatment pathological femoral fractures. The authors' report provides a method for patient with fracture cancer preoperative HIFU lesion ablation followed by combined intramedullary nail fixation.
Objective:To analyze the correlation of degree affective disorder and brain function changes by comparing differences resting-state functional Magnetic Resonance Imaging（rs-fMRI） between healthy volunteers without tinnitus patients with tinnitus. Method:A analysis 19 15 The were divided into mild group severe according to handicap inventory（THI）. Rs-fMRI was collected regional homogeneity（ReHo） analysis, amplitude low-frequency fluctuation（ALFF） fractional low frequency fluctuation（fALFF）...
Abstract The mutational profiles of hypopharyngeal squamous cell carcinoma (HSCC), an anatomical and clinical subtype head neck (HNSCC) was characterized in this study. Whole exome sequencing HSCC tumors (n=15) normal pairs reveals distinct somatic gene mutations to (KDR, ABL-1, ATM, HNF1A), while some others are common HNSCC significantly mutated genes (e.g. TP53, HRAS, NOTCH1 PIK3CA). Copy number analysis shows signatures amplifications(e.g. CCND1) or deletions(e.g. GSTT1). Furthermore,...