A5101568707- Ubiquitin and proteasome pathways
- Cancer-related gene regulation
- Microtubule and mitosis dynamics
- Cancer-related Molecular Pathways
- Cancer, Hypoxia, and Metabolism
- Circular RNAs in diseases
- RNA modifications and cancer
- Phagocytosis and Immune Regulation
- MicroRNA in disease regulation
- Hippo pathway signaling and YAP/TAZ
- Orthodontics and Dentofacial Orthopedics
- Inflammatory mediators and NSAID effects
- Temporomandibular Joint Disorders
- Lymphoma Diagnosis and Treatment
- Extracellular vesicles in disease
- Mesenchymal stem cell research
- CAR-T cell therapy research
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- Complement system in diseases
- Microbial metabolism and enzyme function
- Bone Metabolism and Diseases
- NF-κB Signaling Pathways
- RNA Research and Splicing
- Transgenic Plants and Applications
Shandong Provincial Hospital
2014-2024
Shandong First Medical University
2020-2024
Shandong University
2014-2022
Fourth Hospital of Hebei Medical University
2020
Hebei Medical University
2020
Henan University of Technology
2018-2019
Abstract Glycoprotein prostaglandin D2 synthase (PTGDS) is a member of the lipocalin superfamily and plays dual roles in prostaglandins metabolism lipid transport. PTGDS has been involved various cellular processes including tumorigenesis solid tumors, yet its role carcinogenesis contradictory significance hematological malignancies ill-defined. Here, we aimed to explore expression function diffuse large B-cell lymphoma (DLBCL), especially potential inhibitor, AT56, therapy. Remarkable high...
Long non-coding RNAs (lncRNAs) are non-protein-coding transcripts that play important roles in tumorigenesis and tumor progression. Our study aimed to explore the role of lncRNA MAGI2-AS3 breast cancer metastatic In present study, our results showed can inhibit migration invasion cells. addition, an increase microRNA-374a (miR-374a) expression Bioinformatic analysis predicted correlation between miR-374a. Phosphatase tensin homolog (PTEN) was found be novel mRNA target upregulation inhibited...
Osteosarcoma is a common primary bone tumor in children and adolescents. The drug resistance of osteosarcoma leads to high lethality. Macrophage migration inhibitory factor (MIF) an inflammation-related cytokine implicated the chemoresistance breast cancer. In this study, we isolated novel androstenedione derivative identified as 3,4-dihydroxy-9,10-secoandrosta-1,3,5,7-tetraene-9,17-dione (DSTD). DSTD could inhibit MIF expression MG-63 U2OS cells. inhibition by promoted autophagy inducing...
Exosomes, nanometer-sized membranous vesicles in body fluids, have emerged as promising non-invasive biomarkers for cancer diagnosis. However, the function of exosomes diffuse large B-cell lymphoma (DLBCL) remains elusive. This study aimed to investigate role exosomal miR-107 lymphomagenesis and explore its clinical significance. In this study, decreased miR-107, miR-375-3p, upregulated miR-485-3p were detected plasma DLBCL patients showed potential diagnostic value. Downregulated expression...
Aberrant expression of CUL4B was identified in various types solid cancers. Cumulative evidences support the oncogenic role cancers, including regulation cell proliferation and signal transduction. However, its clinical value potential pathogenic mechanism diffuse large B-cell lymphoma (DLBCL) have not been described previously. Therefore, we hypothesize that overexpressed may contribute to pathogenesis DLBCL. The aim this study is assess biological function DLBCL progression. In our study,...
Abstract Polo-like kinase 4 (PLK4), a key regulator of centriole biogenesis, has recently been shown to play roles in tumorigenesis. Blocking PLK4 expression by interference or targeted drugs exhibits attractive potential improving the efficacy chemotherapy. Nevertheless, role diffuse large B-cell lymphoma (DLBCL) is still undefined. In this study, we discover that target for treatment DLBCL, and demonstrate inhibitor when used combination with doxorubicin. Pharmaceutical inhibition...
Bone regeneration is the ultimate goal of periodontal therapies, in which osteogenic differentiation human ligament stem cells plays a critical role. The tripartite motif (TRIM)16, an E3 ubiquitin ligase, downregulated tissues patients with periodontitis, while role TRIM16 (hPDLSCs) largely unknown. Firstly, we found that was increased throughout media induced hPDLSCs. Then overexpression plasmids and specific short-hairpin RNAs (shRNAs) were constructed to manipulate expression target...
TIPE1, which acts as a cell death regulator, has emerged tumor suppressor in the process of carcinogenesis. However, our recent research demonstrated that it serves an oncogene pathogenesis cervical cancer, indicating role TIPE1 carcinogenesis needs to be further evaluated. In this study, we show is able inhibit breast cancer growth both vivo and vitro. Functionally, inhibits proliferation preferentially by downregulating ERK phosphorylation. Furthermore, expression decreased tissues...
Circular RNAs (circRNAs) are regarded as pivotal regulators in bone metabolism. However, the role of circRNAs osteoblast mineralization remains largely unknown. Herein, we explored expression profiles 4 groups osteoblasts with varying processes. Hsa_circ_0008500 (circ8500), which is upregulated RNA-seq data, sifted through 194 candidate during mineralization. We characterize features novel and find that elevated circ8500 promotes Mechanistically, contains a critical binding site for...
Mechanical stress plays a vital role in osteogenic differentiation of periodontal ligament stem cells (PDLSCs). Cyclic mechanical may up-regulate reactive oxygen species (ROS) level. N-acetylcysteine (NAC) possesses powerful antioxidant capacity. However, it is undefined the impact NAC on stimulated by cyclic PDLSCs. The aim our research was to study effect PDLSCs during under stress.The expression levels osteogenesis markers were used examine ROS production measured flow cytometry. reduced...
Leptin signaling influences osteoblastogenesis and modulates the fate of mesenchymal stem cells (MSCs) during bone cartilage regeneration.Although MSCs abound in osteosarcoma (OS) microenvironment, leptin exhibits pro-tumorigenic properties, leptin's influence on OS progression chemoresistant remains unclear.Using cell viability apoptosis assays, we showed that medium conditioned by leptintreated human promotes cisplatin resistance cultured cells.Moreover, GFP-LC3 expression chloroquine...
Background: Wheat germ, one of the byproducts flour milling, contains abundant physiologically active components. Globulins in wheat germ are a class high-quality functional proteins and have received widespread attention. However, composition globulin（ WGG）and structure typical not yet been proved. The immunological activities immune mechanisms WGG revealed vivo. Objectives: proteomic analysis simulation were studied. immunoregulatory effects on immunosuppressed mice induced by...
To evaluate the morphological and positional changes of mandibular condyle after miniscrew-assisted rapid palatal expansion (MARPE) in skeletal Class III malocclusion adult patients with horizontal deviation (MD).The sample consisted 15 MD (6 males 9 females, mean age 21.58 ± 3.12 years). The CBCT scans were taken before MARPE immediately. pre- post-registered images cranial base mandible measured, respectively, by Mimics.After expansion, distance between superior condylar point Frankfort...
Compound probiotics were used to ferment compound wheat embryo Chinese medicine (CWECM) at 37 °C for a given period, and the fermentation end point was determined based on pH value. The full spectrum of proteins within supernatant by ion mass spectrometry, then analyzed proteomics. difference functional protein CWECM before after analyzed. Additionally, changes in flavor peptides examined. Our results indicated that when performed 96 h, value became stable over time, where it shifted from an...