A5113337313- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Air Quality and Health Impacts
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Climate Change and Health Impacts
- RNA modifications and cancer
- Bone Metabolism and Diseases
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Medical Imaging and Analysis
- Heavy Metal Exposure and Toxicity
- Ferroptosis and cancer prognosis
- MXene and MAX Phase Materials
- Extracellular vesicles in disease
- Traditional Chinese Medicine Analysis
- Thermoregulation and physiological responses
- Genetic factors in colorectal cancer
- Colorectal Cancer Screening and Detection
- Advanced Photocatalysis Techniques
- 2D Materials and Applications
- Spine and Intervertebral Disc Pathology
- Cancer-related gene regulation
- Heavy metals in environment
- Health Systems, Economic Evaluations, Quality of Life
Nanjing University of Chinese Medicine
2019-2025
CM Hospital
2024-2025
Peking University
2023-2025
Western University
2019-2024
King University
2023
Shanghai University of Engineering Science
2022
Jiangsu University
2018
Affiliated Hospital of Jiangsu University
2018
Myeloid-derived suppressor cells (MDSCs) have strong immunosuppressive functions and contribute to the formation of tumor microenvironment. Long non-coding (Lnc) RNAs are highly important factors associated with tumors may be used as markers for diagnosis, which is valuable targeted therapy. LncRNA MALAT1 expressed in various tissues plays a critical role cell proliferation, including tumorigenesis metastasis. However, MDSCs unclear. In this study, we observed an increased proportion...
Metals and nonmetals in drinking water could potentially influence cardiovascular health. The relationship between poor-quality water, major adverse events (MACE), diet is not well studied. aim of this study was to determine whether long-term exposure metals (copper, manganese, aluminum, zinc, cadmium) (selenium, sulfate, nitrate-nitrogen) associated with MACE outcomes, the dietary patterns modify association low-quality MACE. Data from a prospective population-based cohort Yinzhou District,...
<title>Abstract</title> Background Recent research has identified CD31<sup>hi</sup>EMCN<sup>hi</sup> vessels, known as type H which play a crucial role in the specialized bone metabolic microenvironment. These vessels are reported to integrate angiogenesis with osteogenesis, thereby influencing angiogenesis-dependent formation. N6-methyladenosine (m6A) modification, mediated by METTL3, is essential eukaryotic mRNA; however, its formation remains unclear. Methods Herein, H-BMECs were screened...
Although the roles of lncRNA FOXD2-AS1 have been investigated in many types cancers including colorectal cancer (CRC), its functionality remains to be further investigated. Analysis TCGA data set revealed that was up-regulated CRC tissues. This study aimed analyze function CRC.FOXD2-AS1 expression detected by qPCR. A 5-year follow-up performed prognostic value for CRC. Overexpression experiments were interactions among FOXD2-AS1, miR-25-3p and Sema4C. Transwell assays cell invasion...
Ischemia-reperfusion (I/R) injury occurs during cardiac surgery and is the major factor leading to heart dysfunction failure. Our previous study showed that gene microRNA expression profiles are altered in grafts with extended I/R injury. In this study, we, for first time, demonstrated upregulates of Polo-like kinase 2 (Plk2) but decreases miR-128 cells both vitro vivo. Silencing Plk2 using small interfering RNA (siRNA) protects from Antimycin A-induced cell apoptosis/death. also...
While heart transplantation is used as a standard treatment for failure, transplant rejection continues to pose challenge. Recent evidence has shown that circular RNA (circRNA) new type of gene regulator in cell development. Our aim was demonstrate with tolerogenic dendritic cells (Tol-DCs) generated by FSCN1 (circFSCN1) silencing could prevent alloimmune and prolong graft survival transplantation.
Chronic exposure to particulate matter air pollution (PM2.5 ) is associated with chronic rhinosinusitis (CRS). Elevated ambient temperature may increase PM2.5 levels and thereby exacerbate sinonasal symptoms. This study investigates the association between high risk of CRS diagnosis.Patients were diagnosed at Johns Hopkins hospitals from May October 2013-2022, controls matched patients without meanwhile. A total 4752 (2376 cases 2376 controls) identified a mean (SD) age 51.8 (16.8) years....
Abstract Background Oxidative stress results in cell apoptosis/death and plays a detrimental role disease development progression. Stressors alter the miRNA expression profile miRNAs play response to stress. We previously showed that miR-711 is significantly over-expressed extended cold ischemia reperfusion injured hearts heart transplant. In this study, we aimed investigate of cardiac damage oxidative how regulated. Methods Rat line H9c2 cells were cultured exposed conditions (Antimycin A...
Thymocyte selection-associated HMG-BOX (TOX) belongs to a family of transcription factors containing highly conserved region the high mobility group box (HMG-Box). A growing body research has shown that TOX is involved in occurrence and development tumors promotes T-cell exhaustion. We assessed role with The Cancer Genome Atlas (TCGA) Pancancer Data. expression was examined RNA-seq data from TCGA Genotype-Tissue Expression (GTEx) databases. genetic alteration status protein level were...
<title>Abstract</title> Background Intervertebral disc degeneration (IDD) is one of the main factors leading to low back pain. However, its potential pathogenesis targets are poorly understood. Therefore, IDD must be further explored identify more appropriate treatment angles. Objective To investigate effects hypoxia-inducing factor-1α (HIF-1α)/BCL-2 interacting protein 3 (Bnip3)/vascular endothelial growth factor (VEGF) signaling axis on induced by inflammatory tumor necrosis factor-alpha...
<title>Abstract</title> Background TOX (Thymocyte Selection-Associated HMG BOX) belongs to a family of transcription factors with conserved high mobility group box (HMG-box) domain. Research indicates that is involved in tumor development and T cell exhaustion. This study used data from The Cancer Genome Atlas (TCGA) evaluate expression across cancers. Methods was analyzed using RNAseq TCGA the Genotype-Tissue Expression (GTEx) database. Genetic alterations protein levels were assessed via...
Abstract Dendritic cells (DCs) are the main antigen-presenting and play a central role in activating adaptive immunity. How DCs is regulated during their development remains to be further elucidated. Circular RNA (circRNA) new type of non-coding playing critical various cell events. However, little known about circRNA DCs. Using situ hybridization, we found that expressed exonic circular AEBP2 (circAEBP2). circAEBP2 was upregulated mature compared immature Knockdown using small interference...
Background Despite mounting evidence linking neurological diseases with climate change, the link between autism spectrum disorder (ASD) and global warming has yet to be explored. Aims To examine relationship incidence of ASD from 1990 2019 estimate trajectory 2020 2100 globally. Method We extracted meteorological data TerraClimate 2019. association temperature variation, we adopted a two-stage analysis strategy using generalised additive regression model. Additionally, projected future under...
Abstract Background The healthcare sector is a significant contributor to greenhouse gas emissions. Reducing the carbon footprint by adjusting medical disease management structure important for China. Methods We conducted case study, estimated annual of both haemodialysis and peritoneal dialysis patients compared demographic characteristics consumption in each category between (HD) (PD). Linear regression was used explore factors potentially influencing footprint. Findings 271 (143 HD 128...
Abstract Circular RNA (circRNA) has been the focus of research in recent years. However, circRNA is rarely reported dendritic cells (DCs). In our study, Microarray analysis showed that circular AEBP2 (circAEBP2) significantly up-regulated mature DCs compared with immature DCs. Knockdown circAEBP2 DC siRNA arrests at status lower expression MHC class II, CD40, CD80, and CD83, as well decreasing Phosphorylation nuclear factor-kappa B p65. CircAEBP2 -silenced failed to activate allogeneic CD4+...