A5103196148- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Metastasis and carcinoma case studies
- Protein Kinase Regulation and GTPase Signaling
- Colorectal and Anal Carcinomas
- Cancer Immunotherapy and Biomarkers
- Bariatric Surgery and Outcomes
- Vascular anomalies and interventions
- Enzyme Structure and Function
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Cancer-related gene regulation
- Gastrointestinal Tumor Research and Treatment
- Cancer Cells and Metastasis
- Enzyme function and inhibition
- Cancer-related Molecular Pathways
- ATP Synthase and ATPases Research
- Epigenetics and DNA Methylation
- Traditional Chinese Medicine Analysis
- Phytochemistry and biological activity of medicinal plants
- Cancer Treatment and Pharmacology
- PI3K/AKT/mTOR signaling in cancer
- Colorectal Cancer Screening and Detection
- Myasthenia Gravis and Thymoma
- Occupational and environmental lung diseases
China Medical University
2009-2024
First Hospital of China Medical University
2009-2024
Kanazawa Medical University
2009
Gastric cancer (GC) is the fifth most common malignancy and third leading cause of cancer‑associated mortality in world. However, its mechanisms occurrence development have not been clearly elucidated. Furthermore, there no effective tumor marker for GC. Using DNA microarray analysis, present study revealed genetic alterations, screened out core genes as novel markers discovered pathways potential therapeutic targets. Differentially expressed (DEGs) between GC adjacent normal tissues were...
// Peng-Liang Wang 1 , Fang-Tao Xiao Bao-Cheng Gong and Fu-Nan Liu Department of Surgical Oncology, The First Affiliated Hospital China Medical University, Shenyang, Correspondence to: Liu, email: lfn540@126.com Keywords: dietary habit, gastric cancer, cancer prevention, epidemiology Received: February 28, 2017 Accepted: August Published: September 15, ABSTRACT Background: Many studies investigated the association between alcohol drinking risk, but results were controversial. We performed a...
p21-Activated kinase 1 (Pak1), a serine/threonine kinase, has been implicated in cytoskeletal remodelling, cell motility, apoptosis and transformation. However, the role of Pak1 gastric cancer remains unclear. In this study, we detected expression tissues from 40 patients by western blot. Overexpression was associated with progression, metastasis prognosis cancer. addition, found that knockdown significantly inhibited anchorage-dependent anchorage-independent growth cells, markedly xenograft...
To determine the inhibitory effect of Astragalus memebranaceushas on gastric cancer cell supernatant-induced apoptosis human peritoneal mesothelial cells.Human (HPMC) line HMrSV5 was co-incubated with supernatant (MKN45) and/or memebranaceushas. Morphological changes in cells were observed under phase-contrast microscope. Quantitative damage determined by MTT assay. Apoptosis transmission electron microscope and quantified detecting acridine orange/ethidium bromide-stained (AO/EB) condensed...
Glutamate receptor, ionotropic, kainate 3 (GRIK3), as a member of the glutamate receptor family, mainly participated in neuroactive ligand interaction pathway. Other members GRIK family were previously reported to regulate cellular migration, transformation, and proliferation tumor. However, mechanism GRIK3 tumor is still unclear. Therefore, purpose our study was reveal expression clinical significance gastric cancer (GC). First, we performed analysis survival using The Cancer Genome Atlas...
Abstract Gastric cancer is still one of the most common and deadly malignancies in world. Not all patients could benefit from chemotherapy or chemoradiotherapy due to tumor heterogeneity. Therefore, identifying different subgroups an important trend for obtaining more effective responses. However, few molecular classifications associated with chemosensitivity are based on immune–risk status. In this study, we obtained six key immune–related genes. Using these genes, constructed a model...
In this study, we examined effects of soluble factors released by gastric cancer cells on peritoneal mesothelial in vitro and vivo.HMrSV5, a human cell line, was incubated with supernatants from cells. Morphological changes HMrSV5 were observed. Apoptosis observed under transmission electron microscope quantitatively determined MTT assay flow cytometry. Expressions apoptosis-related proteins (caspase-3, caspase-8, Bax, bcl-2) immunochemically evaluated.Conspicuous morphological indicating...
The treatment strategy of patients with locally advanced gastric cancer has undergone notable changes since immune checkpoint inhibitors (ICIs) were developed. Although ICIs are generally well-tolerated, they can also cause serious adverse events, such as autoimmune diseases. In and without a history disease, the incidence myasthenia gravis combined myocarditis caused by ICI is rare. Furthermore, cases ocular gravis, limb weakness or severe dyspnea, although urination difficulties symptoms...
In gastric cancer, various surveillance strategies are suggested in international guidelines. The current study is intended to evaluate the and provide more personalized proposals for cancer medicine. aggregate, 9191 patients with after gastrectomy from 1998 2009 were selected Surveillance, Epidemiology, End Results database. Disease-specific survival was analyzed by Kaplan-Meier method log-rank test. Cox proportional hazards regression analyses used confirm independent prognostic factors....
Background: Early gastric cancer (EGC) with metastatic lymph nodes (mLNs) has a relatively higher recurrence rate and poorer prognosis than EGC without mLNs.However, the postoperative treatment directions of pT1N1M0 vary from different guidelines.This study attempted to confirm value treatments in GC patients.Methods: Overall, 379 patients following gastrectomy 2000 2016 were selected Surveillance, Epidemiology, End Results (SEER) database.Propensity score-matched (PSM) analysis was used...
Abstract Background Evidence suggests that coronavirus disease 2019 (COVID-19) is associated with the risk of cardiovascular diseases (CVDs). However, results are inconsistent, and causality remains to be established. We aimed investigate potential causal relationship between COVID-19 CVDs by using two-sample Mendelian randomization (MR) analysis. Methods Summary-level data for including myocarditis, heart failure (HF), acute myocardial infarction (AMI), arrhythmia venous thromboembolism...
p21-activated kinase 1 (PAK1) is an evolutionarily conserved serine/threonine protein kinase, which has been considered as one of the key regulatory factors in signaling network tumor cells. Therefore, inhibition PAK1 may be a potential approach to treat many types solid tumors. Several allosteric inhibitors have identified, and most well known IPA-3. But its biological activity not satisfied, structure relationship (SAR) unclear. In this study, we designed synthesized 13 by using...
343 Background: Conversion therapy can improve the survival of patients with locally advanced unresectable or potentially resectable metastatic gastric adenocarcinoma. This study was conducted to evaluate efficacy and safety nab-paclitaxel combined oxaliplatin S-1 as a conversion in cancer. Methods: single-arm, multicenter, open-label trial Eligible were administered (150 mg/m 2 , day 1), (85 (80–120 mg/day, days 1–14) every 21 for two four cycles. Radiographic assessments performed after...
Laparoscopic gastrectomy has gained much popularity in the treatment of gastric cancer China. But it is more difficult to perform than open gastrectomy. In recent years, prevalence obesity rapidly increasing and application laparoscopic surgery for these patients still exists controversial. The major obstacle its mainly associated with higher risk complication, technical difficulties, longer operative time conversion rates. surgical difficulties come from accumulated visceral fat tissue that...