A5080585241- Nanoplatforms for cancer theranostics
- Cannabis and Cannabinoid Research
- Photodynamic Therapy Research Studies
- Cancer, Hypoxia, and Metabolism
- Nanoparticle-Based Drug Delivery
- Luminescence and Fluorescent Materials
- Advanced biosensing and bioanalysis techniques
- Neuroscience and Neuropharmacology Research
- Cancer Research and Treatments
- Click Chemistry and Applications
- Dendrimers and Hyperbranched Polymers
- Gastrointestinal Tumor Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Platelet Disorders and Treatments
- Tryptophan and brain disorders
- Chronic Myeloid Leukemia Treatments
- Radiopharmaceutical Chemistry and Applications
- Pancreatic function and diabetes
- RNA Interference and Gene Delivery
- Photochromic and Fluorescence Chemistry
- Cancer Genomics and Diagnostics
- Medical Imaging Techniques and Applications
- Neuroscience of respiration and sleep
- Photoacoustic and Ultrasonic Imaging
- Neuroinflammation and Neurodegeneration Mechanisms
Vanderbilt University Medical Center
2018-2024
Vanderbilt University
2005-2021
University of Pittsburgh
2012-2020
UPMC Hillman Cancer Center
2012-2020
LIG Science (United States)
2019
Washington University in St. Louis
2008-2013
Pittsburg State University
2011
Mallinckrodt (United States)
2009
University of Washington
2006-2008
Georgetown University Medical Center
2007
Background The effectiveness of immune checkpoint inhibitors in colorectal cancer (CRC) is limited due to the low tumor neoantigen load and infiltration most microsatellite-stable (MSS) tumors. This study aimed develop a mitochondria-targeted photodynamic therapy (PDT) approach provoke host antitumor immunity MSS-CRC elucidate underlying molecular mechanisms. Methods role mechanism PDT inhibiting CRC progression inducing pyroptosis were evaluated both vitro vivo. effects sensitization on...
Osteoarthritis (OA) of the joint is a prevalent disease accompanied by chronic, debilitating pain. Recent clinical evidence has demonstrated that central sensitization contributes to OA An improved understanding how pathology impacts upon processing pain crucial for identification novel analgesic targets/new therapeutic strategies. Inhibitory cannabinoid 2 (CB2) receptors attenuate peripheral immune cell function and modulate neuro-immune responses in models neurodegeneration. Systemic...
The type 2 cannabinoid receptor (CB2R) plays a vital role in carcinogenesis and progression is emerging as therapeutic target for cancers. However, the exact of CB2R cancer therapy remains unclear. This has driven increasing efforts to study cancers using molecular imaging tools. In addition, many types overexpress CB2R, expression levels appear be associated with tumor aggressiveness. Such upregulation cells provides opportunities CB2R-targeted high contrast low side effects. present study,...
Cannabinoid CB2 receptor is a particularly attractive target for noninvasive imaging of neuroinflammation and monitoring therapeutic efficacy. Its expression low to undetectable in healthy brain induced resident microglial cells (the macrophage the brain) after cerebral ischemia, injury, neuroinflammatory disease. Additionally, immune migrating across blood−brain barrier typically express receptors, which adds pool this provides reliable indicator inflammation brain. Here, we synthesized...
Phototherapy is a powerful, noninvasive approach for cancer treatment, with several agents currently in clinical use. Despite the progress and promise, most current phototherapy have serious side effects as they can lead to damage healthy tissue, even when photosensitizers are fused targeting molecules due nonspecific light activation of unbound photosensitizer. To overcome these limitations, we developed agent that combines functional ligand near infrared phthalocyanine dye. Our target type...
We developed a molecular imaging agent (MIA), conjugable form of PK11195 (conPK11195) coupled to lissamine dye (Liss-ConPK11195), which targets the peripheral benzodiazepine receptor (PBR). To determine that our compound specifically binds this 18 kDa protein, primarily expressed on mitochondria, we performed classic binding studies live MDA-MB-231 breast cancer cells and measured fluorescence in cell fractions C6 glioma cells. found conPK11195 conjugated fluorophore retained significant its...
Bilingual fluorescent molecules: An array of asymmetric carbocyanines capable dual fluorescence emissions in the near-infrared region is described (see image). The molecules are robust different pH and solvents. Additionally, each peak possesses a distinct lifetime. These properties retained after conjugation dyes with small bioactive peptides. Supporting information for this article available on WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z800475_s.pdf or from author. Please...
Photodynamic therapy (PDT) has received increased attention over the past decades with potential to noninvasively treat cancer via light exposure. Due limited penetration depth within tissue (typically less than 1 cm), PDT optical fiber typically needs be placed close cancerous region ensure treatment outcome. In this article, we present a novel soft robot laparoscope design that enables accurate and safe deployment of for pancreatic tumor treatment. To achieve this, proposed is able produce...
Cannabinoid CB2 receptors (CB2R) hold promise as therapeutic targets for treating diverse diseases, such cancers, neurodegenerative pain, inflammation, osteoporosis, psychiatric disorders, addiction, and immune disorders. However, the fundamental role of CB2R in regulation diseases remains unclear, largely due to a lack reliable imaging tools receptors. The goal this study was develop CB2R-targeted molecular probe evaluate specificity using human tumor cells that naturally overexpress CB2R....
Recent studies indicate that the type 2 cannabinoid receptors (CB R ) have become an attractive target for treating a variety of pathologies, including cancers, neurodegenerative diseases, inflammation, pain, osteoporosis, immunological disorders and drug abuse. In addition, it appears many these diseases up-regulated CB expression. However, precise role in regulation remains unclear. The ability to specifically image would contribute develop reliable -based therapeutic approaches with...
Objectives To utilize phosphorescence to monitor hypoxic microenvironment in solid-tumors and investigate cancer chemotherapeutic effects vivo. Methods A hypoxia-sensitive probe named BTP was used solid-tumors. The low-dose metronomic treatment with cisplatin anti-angiogenetic programs. properties of were detected by a spectrofluorometer. cytotoxicity utilized cell necrosis apoptosis, which evaluated trypan blue dye exclusion Hoechst33342 plus propidium iodide assays. Tumor-bearing mouse...
The success of targeted cancer therapy largely relies upon the selection target and development efficient therapeutic agents that specifically bind to target. In current study, we chose a cannabinoid CB2 receptor (CB2R) as new used CB2R-targeted photosensitizer, IR700DX-mbc94, for phototherapy treatment. IR700DX-mbc94 was prepared by conjugating IR700DX, mbc94, whose binding specificity CB2R has been previously demonstrated. We found treatment using greatly inhibited growth positive tumors...
Starting from our previously developed c-KIT kinase inhibitor CHMFL-KIT-8140, through a type II binding element hybrid design approach, we discovered novel compound 18 (CHMFL-KIT-64), which is potent against wt and broad spectrum of drug-resistant mutants with improved bioavailability. exhibits single-digit nM potency T670I in the biochemical assay displays great potencies most gain-of-function mutations juxtamembrane domain, ATP pocket (except V654A), activation loops D816V). In addition,...