This paper reports a convenient method for immobilizing biologically active ligands to self-assembled monolayers of alkanethiolates on gold (SAMs). methodology is based that present maleimide and penta(ethylene glycol) groups. The groups react efficiently with thiol-terminated ligands, whereas the prevent nonspecific adsorption protein substrate. rate selectivity immobilization ferrocene-thiol conjugate were characterized using cyclic voltammetry. presents three examples biochips prepared...

Alkanephosphonic acids assemble from solution on the native oxide surface of titanium to form alkane chain ordered films which, however, are easily removed by solvent rinse. In contrast, assembling alkanephosphonic acid followed gentle heating gives an film which is strongly surface-bound; this resists removal washing or simple mechanical peel testing. Surface imaging atomic force microscopy shows comprehensive coverage aggregated islands, with elevations each consistent monolayer formation....

Phosphonate−steel interactions have been industrially significant for decades, but details of the phosphonate−steel interface not yet characterized. Self-assembled monolayers phosphonic acids were formed on stainless steel 316L by room-temperature solution deposition. The are covalently bound to surface as phosphonates in a bidentate manner, determined diffuse reflectance Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy. Complete coverage is confirmed contact...

Development of coatings to minimize unwanted surface adsorption is extremely important for their use in applications, such as sensors and medical implants. Self-assembled monolayers (SAMs) are an excellent choice that nonspecific because they can be uniform have a very high coverage. Another equally characteristic stability. In the present study, both bonding mechanism stability stearic acid SAMs on two aluminum oxides (single-crystal C-plane oxide (sapphire) amorphous (alumina))...

Stainless steel 316L is a widely used biomaterial substrate whose biocompatibility could be improved by surface modification. As first step in this process, self-assembled monolayers of octanoic acid, octadecylcarboxylic 16-hydroxyhexadecanoic 12-aminododecanoic and 1,12-dodecane dicarboxylic acid have been formed on the native oxide stainless simple, one-step solution deposition method. The ordering, close-packing, coverage were characterized diffuse reflectance infrared spectroscopy,...

Native oxide surfaces of stainless steel 316L and Nitinol alloys their constituent metal oxides, namely nickel, chromium, molybdenum, manganese, iron, titanium, were modified with long chain organic acids to better understand film formation. The adhesion stability films octadecylphosphonic acid, octadecylhydroxamic octadecylcarboxylic octadecylsulfonic acid on these substrates examined in this study. formed analyzed by diffuse reflectance infrared Fourier transform spectroscopy, contact...

The performance of an in situ-forming injectable membrane designed to retain antibody molecules vivo is described. system entails aqueous mixture peptide amphiphiles (referred as"EAK16-II" and "EAKH6") intermediate proteins (anti-H6 protein A/G) through which therapeutic IgG are colocalized oriented. Scanning electron micrographs show localized on the EAK16-II/EAKH6 membrane. were captured via specific interactions remained biologically active vitro. Upon administration into mice...

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTADDITION / CORRECTIONThis article has been corrected. View the notice.Bonding Organics to Ti Alloys: Facilitating Human Osteoblast Attachment and Spreading on Surgical Implant MaterialsEllen S. Gawalt, Michael J. Avaltroni, P. Danahy, Brett M. Silverman, Eric L. Hanson, Kim Midwood, Jean E. Schwarzbauer, Jeffrey SchwartzView Author Information Department of Chemistry, Princeton University, Princeton, New Jersey 08544-1009, Molecular Biology,...

Shape memory alloys such as nitinol (NiTi) have gained interest due to their unique and unusual properties of thermal shape memory, superelasticity, good damping properties. Nitinol is mainly used for medical purposes. In order control the surface this alloy, self-assembled monolayers (SAMs) were formed characterized on native oxide first time. Factors which affect formation SAMs, head group functionality, chain length, tail varied analyzed. Functionalized alkyl phosphonic acid molecules...

Abstract: Over 500,000 bone graft or bio‐implant procedures are performed annually in the United States. It has been reported that osseous autograft procurement may result donor site complications and allografts have associated with disease transmission. Ceramic scaffolds only osteoconductive, limiting their clinical use. The objective of this study was to create a filler substitute regenerating properties similar natural bone. Therefore, melatonin platelet‐rich plasma (PRP) were utilized...

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTEnhanced Bonding of Alkanephosphonic Acids to Oxidized Titanium Using Surface-Bound Alkoxyzirconium Complex InterfacesEllen S. Gawalt, Gang Lu, Steven L. Bernasek, and Jeffrey SchwartzView Author Information Department Chemistry, Princeton University, Princeton, New Jersey 08544-1009 Cite this: Langmuir 1999, 15, 26, 8929–8933Publication Date (Web):October 7, 1999Publication History Received12 July 1999Published online7 October inissue 1 December...

ADVERTISEMENT RETURN TO ISSUEPREVCorrectionORIGINAL ARTICLEThis notice is a correctionBonding Organics to Ti Alloys: Facilitating Human Osteoblast Attachment and Spreading on Surgical Implant Materials CorrectionsE. S. Gawalt, M. J. Avaltroni, P. Danahy, B. Silverman, E. L. Hanson, K. Midwood, Schwarzbauer, SchwartzCite this: Langmuir 2003, 19, 17, 7147Publication Date (Web):July 25, 2003Publication History Published online25 July 2003Published inissue 1 August...

The ability to navigate and understand the chemical literature is integral scientific research process. Learning these skills therefore an important, though often overwhelming, part of undergraduate education. We describe inquiry-based program designed help chemistry students begin learn search read literature. semester-long used within honors general course but could be during recitation sections a larger lecture course. It involves classroom library tutorials activities that introduce...

Eutectic gallium–indium nanoparticles (EGaIn NPs) were produced and subsequently functionalized with decylphosphonic acid under various conditions the goal of producing highly stable room-temperature liquid metal colloids. Fourier transform infrared spectroscopy was used to determine phosphonic (PA) bonding modes (e.g., bidentate, tridentate) as a function treatment conditions. The strongest (i.e., predominantly found take place elevated temperature (reflux in hexanes), whereas lower bulk...

A surface-initiated polymerization of styrene on carboxylic acid terminated phosphonic monolayers was utilized to increase the corrosion resistance nitinol and nickel oxide surfaces. Alkyl chain ordering, organic reactions, wettability, film quality polymers were determined by infrared spectroscopy, atomic force microscopy, matrix-assisted laser desorption ionization spectrometry, water contact angles. The polystyrene proved be a better barrier than analysis with cyclic voltammetry...

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTElectrochemically Active Surface Zirconium Complexes on Indium Tin OxideSusan K. VanderKam, Ellen S. Gawalt, Jeffrey Schwartz, and Andrew B. BocarslyView Author Information Department of Chemistry, Princeton University, Princeton, New Jersey 08544-1009 Cite this: Langmuir 1999, 15, 19, 6598–6600Publication Date (Web):July 13, 1999Publication History Received28 January 1999Revised11 May 1999Published online13 July inissue 1 September...