A5056744170- Periodontal Regeneration and Treatments
- Bone Tissue Engineering Materials
- Circadian rhythm and melatonin
- Estrogen and related hormone effects
- Morinda citrifolia extract uses
- 3D Printing in Biomedical Research
- Endometriosis Research and Treatment
- Advanced Polymer Synthesis and Characterization
- Orthopaedic implants and arthroplasty
- Dental Trauma and Treatments
- Silicone and Siloxane Chemistry
- Medical and Biological Ozone Research
- Oral and Maxillofacial Pathology
- Additive Manufacturing and 3D Printing Technologies
- Synthesis and properties of polymers
- Lipid Membrane Structure and Behavior
- Neuroendocrine regulation and behavior
- Surgical Sutures and Adhesives
- RNA Interference and Gene Delivery
- Bone and Dental Protein Studies
- Erythrocyte Function and Pathophysiology
- Neurological Disorders and Treatments
- Hemostasis and retained surgical items
- Blood properties and coagulation
- Tissue Engineering and Regenerative Medicine
Université Laval
2016-2021
Duquesne University
2008-2019
Carnegie Mellon University
2014-2016
Mylan (United States)
2012
A major challenge during the engineering of voluminous bone tissues is to maintain cell viability in central regions construct. In vitro prevascularization substitutes relying on endothelial bioprinting has potential resolve this issue and replicate native microvasculature. Laser-assisted (LAB) commonly uses biological layers hydrogel, called 'biopapers', support patterns printed cells constitute basic units The self-assembly approach tissue allows production biomimetic cell-derived...
Abstract: Over 500,000 bone graft or bio‐implant procedures are performed annually in the United States. It has been reported that osseous autograft procurement may result donor site complications and allografts have associated with disease transmission. Ceramic scaffolds only osteoconductive, limiting their clinical use. The objective of this study was to create a filler substitute regenerating properties similar natural bone. Therefore, melatonin platelet‐rich plasma (PRP) were utilized...
In this study, the effects of light/dark cycle, hormone replacement therapy (HRT), and nocturnal melatonin supplementation on osteogenic markers serum levels were examined in a blind mouse model (MMTV-Neu transgenic mice). Melatonin strain (FVB/N) with retinal degeneration (rd-/-) fluctuate diurnal manner, suggesting that these mice, although blind, still perceive light. Real-time RT-PCR analyses demonstrated Runx2, Bmp2, Bmp6, Bglap, Per2 mRNA coincide levels. The effect chronic HRT (0.5 mg...
Abstract A series of melatonin analogs obtained by the replacement ether methyl group with larger arylalkyl and aryloxyalkyl substituents was prepared in order to probe receptors for MT 1 ‐selectivity. The most ‐selective agents 11 15 were substituted a Ph(CH 2 ) 3 or PhO(CH group. Compounds displayed 11.5‐fold 11‐fold higher affinity than subtype. Interestingly, our binding assay have shown considerably ‐affinity selectivity reference ligand, dimeric agomelatine 1a .
ABSTRACT Homogenous amphiphilic crosslinked polymer films comprising of poly(ethylene oxide) and polysiloxane were synthesized utilizing thiol‐ene “ click ” photochemistry. A systematic variation in composition was Carried out to obtain high quality with varied amount siloxane oxide). These showed improved gas separation performance permeabilities good CO 2 /N selectivity. Furthermore, the resulting also tested for its biocompatibility, as a carrier media which allow human adult mesenchymal...
Achieving optimal bone defect repair is a clinical challenge driving intensive research in the field of tissue engineering. Many strategies focus on seeding graft materials with progenitor cells prior to vivo implantation. Given benefits closely mimicking structure and function natural materials, authors hypothesize that under specific culture conditions, human adipose-derived stem/stromal (hASCs) can solely be used engineer reconstructed osseous tissues (hROTs) by undergoing osteoblastic...
Morinda citrifolia (noni) is reported to have many beneficial properties, including on immune, inflammatory, quality of life, and cancer endpoints, but little known about its ability prevent or treat breast cancer. To test anticancer potential, the effects Tahitian Noni Juice (TNJ) mammary carcinogenesis were examined in MMTV-neu transgenic mice. Mammary tumor latency, incidence, multiplicity, metastatic incidence unaffected by TNJ treatment, which suggests that it would not increase...
Melatonin has numerous anti-cancer properties reported to influence cancer initiation, promotion, and metastasis. With the need for effective hormone therapies (HT) treat menopausal symptoms without increasing breast risk, co-administration of nocturnal melatonin with a natural, low-dose HT was evaluated in mice that develop primary metastatic mammary cancer. Individually, (MEL) estradiol-progesterone therapy (EPT) did not significantly affect development through age 14 months, but, when...
In vitro prevascularization has the potential to address challenge of maintaining cell viability at core engineered constructs, such as bone substitutes, and improve survival tissue grafts by allowing quicker anastomosis host microvasculature. The self-assembly approach engineering allows production biomimetic bone-like constructs including extracellular matrix living human adipose-derived stromal/stem cells (hASCs) induced towards osteogenic differentiation. We hypothesized that addition...
Erythrocytes have been described as advantageous drug delivery vehicles. In order to ensure an adequate circulation half-life, erythrocytes may benefit from protective enhancements that maintain membrane integrity and neutralize oxidative damage of proteins otherwise facilitate their premature clearance circulation. Surface modification using rationally designed polymers, synthesized via atom-transfer radical polymerization (ATRP), further expand the field membrane-engineered red blood...
Tahitian Noni Juice (TNJ) has grown in popularity to self‐treat a myriad of ailments including cancer. The efficacy TNJ on cancer is understudied. aim this study was investigate the use for prevention primary and metastatic breast (BC) using neu mouse model. effects were analyzed estrus cycling gene modulation mammary tissue sexually mature female mice. Mice receiving 10% their drinking water had one less cycle over 30 day period compared controls. Microarray analysis revealed that genes...