A5006402513- Alzheimer's disease research and treatments
- Gut microbiota and health
- Neurological Disease Mechanisms and Treatments
- Bone Tissue Engineering Materials
- Tryptophan and brain disorders
- Advanced Glycation End Products research
- Orthopaedic implants and arthroplasty
- Mesenchymal stem cell research
- Neuroinflammation and Neurodegeneration Mechanisms
- Medical and Biological Sciences
- Lipid Membrane Structure and Behavior
- Bone health and treatments
- Essential Oils and Antimicrobial Activity
- Medicinal Plants and Neuroprotection
- Supramolecular Self-Assembly in Materials
- Dietary Effects on Health
- Diet and metabolism studies
- Bone Metabolism and Diseases
- Nuts composition and effects
- Mitochondrial Function and Pathology
- Salivary Gland Disorders and Functions
- Protease and Inhibitor Mechanisms
- Oral microbiology and periodontitis research
- Cancer-related Molecular Pathways
- Laser Applications in Dentistry and Medicine
Nazarbayev University
2015-2025
Al-Farabi Kazakh National University
2017
Satbayev University
2014
University of Missouri
2008-2013
Abstract We have investigated the diversity and composition of gut microbiotas isolated from AD (Alzheimer's disease) patients (n = 41) healthy seniors 43) Nur-Sultan city (Kazakhstan). The microbiota was characterized by 16S ribosomal RNA sequencing. Our results demonstrated significant differences in bacterial abundance at phylum, class, order, genus levels compared to aged individuals. Relative analysis has revealed increased amount taxa belonging Acidobacteriota, Verrucomicrobiota,...
Recent studies have suggested that periodontal disease and alterations in the oral microbiome may be associated with cognitive decline Alzheimer’s (AD) development. Here, we report a case-control study of microbiota diversity AD patients compared to healthy seniors from Central Asia. We characterized bacterial taxonomic composition (n = 64) group 71) using 16S ribosomal RNA sequencing. According our results, has higher microbial diversity, an increase Firmicutes decrease Bacteroidetes group....
Low vitamin D status is linked to disturbance in cognitive performance. This study explored possible ways how composition and functional capacity of the gut microbiome affects metabolism, directing serum (VitD) levels memory impairmets. It was found that composition, characterized by an increase relative abundance Enterococcus correlated with deficiency and, as consequence, impairments. A key mechanism identified differential utilization short-chain fatty acids (SCFAs) produced bacteria...
The aim was to evaluate morphological effect of Cdc42 inhibition in mesenchymal stem cells (MSCs) on the restoration process bone defects during late post-traumatic period 24-months male rats with ulnar fractures. Material and methods . experiment involved adult Wistar (males, weighing 400–500 grams, aged 24 months; n=40) undergoing diaphysis osteotomy. After injury, animals were randomized into four groups (10 per group). Group I served as controls received no treatment. II administered...
Cyanobacteria produce a wide range of structurally diverse cyanotoxins and bioactive cyanopeptides in freshwater, marine, terrestrial ecosystems. The health significance these metabolites, which include genotoxic- neurotoxic agents, is confirmed by continued associations between the occurrence animal human acute toxic events and, long term, cyanobacteria neurodegenerative diseases. One implicated mechanisms includes misincorporation cyanobacterial non-proteogenic amino acids leading to...
Recent studies strongly suggest that gut microbiome can influence brain functions and contribute to the development of Alzheimer’s disease (AD). However, reported changes in microbiomes AD patients from different countries are not similar, more research is needed reveal relationships between human diverse ethnic populations. There also an assumption microbiome‐associated peripheral inflammation might drive sporadic AD. This cross‐sectional study aimed at analyzing microbial profile exploring...
An increasing amount of evidence supports the notion that cytotoxic effects amyloid-β peptide (Aβ), main constituent senile plaques in Alzheimer's disease (AD), are strongly associated with its ability to interact membranes neurons and other cerebral cells. Aβ is derived from amyloidogenic cleavage amyloid precursor protein (AβPP) by β- γ-secretase. In nonamyloidogenic pathway, AβPP cleaved α-secretases. These two pathways compete each other, enhancing non-amyloidogenic pathway has been...
An inhibitor of small Rho GTPase Cdc42, CASIN, has been shown to reduce cancer cell proliferation, migration, and invasion, yet it several limitations, including rapid drug elimination low bioavailability, which prevents its systemic administration. In this study, we designed characterized a nanoparticle-based delivery system for CASIN encapsulated within poly(lactide-co-glycolide)-block-poly(ethylene glycol)-carboxylic acid endcap nanoparticles (PLGA-PEG-COOH NPs) targeted inhibition Cdc42...
Abstract Background The role of adiponectin (ADIPOQ) in Alzheimer’s disease (AD) has been documented, however, demonstrating controversial results. In this study, we investigated blood serum ADIPOQ levels, methylation the gene promoter, and receptors (AdipoR1 AdipoR2) expression samples isolated from AD patients healthy controls. Methods We performed a case–control study including 248 subjects (98 150 controls); AdipoR1, AdipoR2 levels PBMC were measured by ELISA Kits, was analyzed using...
Despite the significant number of research institutions and rich scientific heritage, published from Central Asia (Kazakhstan, Uzbekistan, Kyrgyzstan, Tajikistan, Turkmenistan) is traditionally underrepresented in international literature. The goal this paper was to analyze publication patterns Asian countries, explore factors that contributed productivity Kazakhstan.Publication evaluated using data generated by SCImago Journal & Country Rank over period 1996-2014 for all 15 former Soviet...