A5069853687- Gut microbiota and health
- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Acute Lymphoblastic Leukemia research
- Salivary Gland Disorders and Functions
- Oral microbiology and periodontitis research
- Obesity, Physical Activity, Diet
- Mycobacterium research and diagnosis
- Acute Myeloid Leukemia Research
- Ginseng Biological Effects and Applications
- Probiotics and Fermented Foods
- Monoclonal and Polyclonal Antibodies Research
- Lipid metabolism and disorders
- Galectins and Cancer Biology
- Climate Change and Health Impacts
- Spondyloarthritis Studies and Treatments
- Tryptophan and brain disorders
- Bipolar Disorder and Treatment
- Clinical Nutrition and Gastroenterology
- Health, Environment, Cognitive Aging
- Chemotherapy-induced organ toxicity mitigation
- Nutrition and Health in Aging
- Microbial Metabolites in Food Biotechnology
- Vitamin D Research Studies
Nazarbayev University
2021-2025
Astana Medical University
2020-2024
Recent studies have suggested that periodontal disease and alterations in the oral microbiome may be associated with cognitive decline Alzheimer’s (AD) development. Here, we report a case-control study of microbiota diversity AD patients compared to healthy seniors from Central Asia. We characterized bacterial taxonomic composition (n = 64) group 71) using 16S ribosomal RNA sequencing. According our results, has higher microbial diversity, an increase Firmicutes decrease Bacteroidetes group....
Low vitamin D status is linked to disturbance in cognitive performance. This study explored possible ways how composition and functional capacity of the gut microbiome affects metabolism, directing serum (VitD) levels memory impairmets. It was found that composition, characterized by an increase relative abundance Enterococcus correlated with deficiency and, as consequence, impairments. A key mechanism identified differential utilization short-chain fatty acids (SCFAs) produced bacteria...
This study aimed to identify the oral microbial signature of Kazakh female rheumatoid arthritis (RA) patients. A total 75 patients who met American College Rheumatology 2010 classification criteria for RA and 114 healthy volunteers were included in study. Amplicons 16S rRNA gene sequenced analyze composition. We identified significant differences bacterial diversity abundance between control groups, as measured by Shannon (p value = 0.0205) Simpson 0.00152) indices. The samples from had...
Objective The primary objective is to study the impact of gut microbiota and their interactions with diverse immunological markers on development rheumatoid arthritis. Methods This was performed in Astana, Kazakhstan, included 77 Kazakh female patients older than 18 years, who met American College Rheumatology 2010 classification criteria for arthritis (RA), 113 healthy controls. DNA extracted from fecal samples obtained all participants subsequent sequencing at 16S rRNA gene V1-V3 locus,...
Introduction: Dietary habits and eating patterns of individuals have a significant impact on overall health. Proper nutrition is vital to preventing chronic diseases improving physical mental performance. Kazakhstan, rapidly developing country in Central Asia, offers unique opportunity study the diverse dietary behavior its population due cultural, ethnic geographic differences. Purpose: nutritional status persons aged 18 years older various regions Kazakhstan. Materials methods: The was...
Relevance. Rheumatoid arthritis (RA) is a condition with an unclear cause, marked by inflammation affecting the synovial tissue of joints, cartilage, and bone. RA can extend to areas outside joints,autoantibodies production progressive disability. affects approximately 0.24% 1% adults globally, women being affected 2 3 times more frequently than men. In recent years numerouse studies showed significant role micribiome in developement. Regardless using disease-modifying anti-rheumatic drugs...
Introduction. Rheumatoid arthritis (RA) is an autoimmune disease of unknown etiology that leads to disability due articular and extra-articular damage. RA prevalence variable. The most common among females with a 3 : 1 ratio. interaction environmental host factors contributes development. Currently, the genome-wide association studies (GWAS) give opportunity uncover genetic background. Anticitrullinated peptide antibody (ACPA) highly specific antibody, associated poor prognosis severe course...
BACKGROUND: The prevalence of rheumatoid arthritis (RA) is 1% in the global population. lack epidemiological studies developing countries makes it difficult to obtain a complete picture RA. RA develops due interaction multiple genetic and environmental factors, though contribution these factors various disease occurrence seen different populations unclear. AIM: aim our study was analyze dynamics general incidence among population Kazakhstan 2017–2019 as well investigate three most common...
BACKGROUND: Rheumatoid arthritis (RA) prevalence according to the worldwide epidemiological data varies from 0.4% 1.3%. The disability and mortality rate in RA is high. clinic various, compiles articular systemic manifestations. AIM: aim of our study was investigate clinical course Kazakhstani patients living North region country. METHODS: 81 women at age 30–55 years with a verified diagnosis who have lived Kazakhstan for least 10 were recruited study. All participants examined by...
Relevance: Kidney functions in treating acute myeloblastic leukemia (AML) undergo serious effects, especially elderly patients. Chemotherapeutic drugs used to prepare for hematopoietic stem cell transplantation (HSCT) inevitably affect patients’ kidney function. Moreover, involutive changes the kidneys can physiologically decrease function.
 The study aimed evaluate function an patient with AML after HSCT.
 Methods: article describes a clinical case of who underwent allogeneic...
Relevance: Kidney functions in treating acute myeloblastic leukemia (AML) undergo serious effects, especially elderly patients. Chemotherapeutic drugs used to prepare for hematopoietic stem cell transplantation (HSCT) inevitably affect patients’ kidney function. Moreover, involutive changes the kidneys can physiologically decrease function.
 The study aimed evaluate function an patient with AML after HSCT.
 Methods: article describes a clinical case of who underwent allogeneic...
Relevance. Rheumatoid arthritis (RA) is a chronic, autoimmune disease characterized by symmetrical deforming and systemic manifestations, such as damage to the cardiovascular, respiratory systems, skin. The prevalence of RA high. Worldwide incidence ranges from 0.24 1% population. 2–3 times more common in women than men. peak occurs working age, 35 64 years. Untreated can lead not only patient disability, but also death. In this connection, pressing problem modern medicine. recent years,...
Актуальность: Ревматоидный артрит (РА) является одним из тяжелых иммуновоспалительных заболеваний суставов, распространенность которого составляет 0,5-2% среди взрослого трудоспособного населения. При этом РА встречается у женщин в 2-3 раза чаще, чем мужчин. В Республике Казахстан 0,36–0,38%, а заболеваемость равна 0,085–0,087%. Основу патогенеза составляют нарушения иммунного ответа, лимфоцитарная и цитокиновая системы осуществляют важную роль возникновении прогрессировании заболевания....