A5017724816- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Gut microbiota and health
- SARS-CoV-2 and COVID-19 Research
- COVID-19 and Mental Health
- Organ Transplantation Techniques and Outcomes
- Pregnancy and Medication Impact
- Food Security and Health in Diverse Populations
- Liver Disease Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Viral Infections and Immunology Research
- COVID-19 and healthcare impacts
- Clostridium difficile and Clostridium perfringens research
- Inflammasome and immune disorders
- Clinical Nutrition and Gastroenterology
- Mechanical Circulatory Support Devices
- Adipokines, Inflammation, and Metabolic Diseases
- Cytokine Signaling Pathways and Interactions
- Tryptophan and brain disorders
- Heart Failure Treatment and Management
- Nutrition and Health in Aging
- Liver Disease and Transplantation
- Vitamin D Research Studies
- COVID-19 epidemiological studies
- Atherosclerosis and Cardiovascular Diseases
Astana Medical University
2024-2025
Low vitamin D status is linked to disturbance in cognitive performance. This study explored possible ways how composition and functional capacity of the gut microbiome affects metabolism, directing serum (VitD) levels memory impairmets. It was found that composition, characterized by an increase relative abundance Enterococcus correlated with deficiency and, as consequence, impairments. A key mechanism identified differential utilization short-chain fatty acids (SCFAs) produced bacteria...
We present the findings from an evaluation of 144 survivors who experienced post-COVID-19 complications or reinfection. The assessment was conducted at 1, 3, and 6 months following their discharge intensive post-COVID care center. encompassed a comprehensive analysis clinical life-critical indicators mental health states. Based on lung CT scans, pneumonia identified in 73% patients, categorized into four severity groups according to conditions: mild (26%), moderate (57%), severe (14%),...
Annotation Background. The aim of this study was to investigate the relationship between Apolipoprotein B/Apolipoprotein A1 ratio and risk metabolically associated fatty liver disease, considering lipid profile variations determine whether can serve as an independent predictor disease its cardiovascular risks. Methods. A total 377 patients diagnosed with coexisting were stratified into high-risk very groups based on established clinical imaging criteria. Lipid profiles, B, levels measured,...
Abstract There is a scarcity of publications evaluating the performance national liver transplantation (LTx) program in Kazakhstan. Spanning from 2012 to 2023, it delves into historical trends LTx surgeries, transplant centers, and cohort patients awaiting LTx. Survival analysis for those LTx, using life tables Kaplan–Meier, complemented by time series projecting developments until 2030. The overall per million population (pmp) rate varied 0.35 3.77, predominantly favoring living donor Liver...
Abstract Kazakhstan has one of the lowest heart transplantation (HTx) rates globally, but there are no studies evaluating outcomes HTx. This study aimed to provide a comprehensive analysis national HTx program over 12-year period (2012–2023). Survival cohort was conducted using life tables, Kaplan‒Meier curves, and Cox regression methods. Time series applied analyze historical trends in per million population (pmp) make future projections until 2030. The number patients awaiting evaluated...
ABSTRACT This study provides a comprehensive assessment of how urban-rural divides influence gut microbial diversity and composition across the distinct geographical landscapes Kazakhstan, elucidating intricate interplay between lifestyle, environment, microbiome. In this prospective cohort study, we enrolled 651 participants from urban centers rural settlements following ethical approval informed consent. Comprehensive demographic, dietary, stool sample data were collected. 16S rRNA gene...
Background First reported case of Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) in Kazakhstan was identified March 2020. Many specialized tertiary hospitals including National Research Cardiac Surgery Center (NRCSC) were re-organized to accept disease 2019 (COVID-19) infected patients during summer months Although many studies from worldwide their experience treating with COVID-19, there are limited data available the Central Asia countries. The aim this study is...
The aims of this study were to analyze cytokine profiles in patients with COVID-19, gain insights into the immune response during acute infection, identify cytokines associated disease severity and post-COVID complications, explore potential biomarkers for prognosis therapeutic targets. Using a multiplex analysis, we studied pattern 294 COVID-19 varying severities infection. Our findings revealed that was elevated levels IL-15, IL-8, fractalkine. Severe/extremely severe forms comparison...
End-stage kidney disease requires comprehensive management strategies to ensure patient survival and improve quality of life. Kidney transplantation remains the preferred treatment option, offering superior long-term outcomes. However, graft rejection a significant concern, pediatric patients often require tailored immunosuppressive regimens due differences in immune response compared adults. Although past decade has seen improvements among transplant recipients, many questions remain...
In the present study, a systematic literature review was conducted to examine prevalence of homo- and heterozygous forms Familial hypercholesterolemia among different racial ethnic groups. (FH) is an inherited disorder characterised by elevated blood levels cholesterol low-density lipoprotein (LDL), which increases risk cardiovascular disease. Databases PubMed, Web Science, Elsiever were searched only peer-reviewed articles with large number contributors sufficient ethnicity data included....
Background: During the acute phase of COVID-19, a number immunological abnormalities have been reported, but few studies longitudinally analyzed specific subsets peripheral blood lymphocytes. Methods: In this observational, prospective, and longitudinal study, adult patients developing pneumonia during COVID-19 pandemic followed up for 12 months. Peripheral lymphocyte were assessed (with focus on memory markers) at 6 time points after disease onset until Results: A total 76 with...
Background. Chronic heart failure (CHF) is a global health issue with high mortality rates. According to statistical data, in Kazakhstan, 4.7% of the population suffers from CHF, which amounts approximately 320,000 people. In United States, 6.7 million individuals are affected, projections rising 8.5 by 2030. Despite advancements treatment, rates remain high. Recent studies highlight role gut microbiota systemic inflammation, key factor cardiovascular diseases. Exploring offers novel...
Abstract Background Long COVID-19 symptoms appeared in many survivors. However, the prevalence and associated with long COVID its comorbidities have not been established. Methods Between May September 2020, we included 312 patients post-COVID-19 from 21 primary care centers if they had any persistent for at least three months first onset of disease. On 6 follow up, their lung function was assessed by CT spirometry, whereas cardiac electrocardiogram (ECG), Holter ECG, Echocardiography,...
Background. Long COVID-19 symptoms appeared in many survivors. However, the prevalence and associated with long its comorbidities have not been established. Methods. In total, 312 patients from 21 primary care centers were included study. At six-month follow-up, their lung function was assessed by computerized tomography (CT) spirometry, whereas cardiac electrocardiogram, Holter ECG, echocardiography, 24 h blood pressure monitoring, a six-minute walk test (6MWT). Results. Of persons...
Введение. Борьба с COVID-19 стала основной проблемой для всего мира и необходимо как можно скорей разработать эффективные стратегии. В настоящее время клинические исследования продолжаются, но предметом особого клинического изучения стал препарат ремдесивир. Инициированные несколько клинических исследований, включая Beigel et al. (ACCT 1) [4], Goldman [13] Spinner [15], оценки безопасности эффективности ремдесивира у пациентов показали, что данный противовирусный имеет хороший потенциал...