A5081133227- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Transplantation: Methods and Outcomes
- COVID-19 Clinical Research Studies
- Lipoproteins and Cardiovascular Health
- Atrial Fibrillation Management and Outcomes
- Long-Term Effects of COVID-19
- Heart Failure Treatment and Management
- Cardiac Arrest and Resuscitation
- Cardiac electrophysiology and arrhythmias
- Gut microbiota and health
- Organ Transplantation Techniques and Outcomes
- Cardiac pacing and defibrillation studies
- SARS-CoV-2 and COVID-19 Research
- Acute Myocardial Infarction Research
- Congenital Heart Disease Studies
- Cardiac Ischemia and Reperfusion
- Cardiomyopathy and Myosin Studies
- Cardiac Arrhythmias and Treatments
- Fuel Cells and Related Materials
- Cardiac Valve Diseases and Treatments
- COVID-19 and healthcare impacts
- Antiplatelet Therapy and Cardiovascular Diseases
- Clostridium difficile and Clostridium perfringens research
- Atherosclerosis and Cardiovascular Diseases
Astana Medical University
2024-2025
National Research Center for Maternal and Child Health
2014-2024
Nazarbayev University
2024
University Medical Center
2024
University Hospital and Clinics
2024
Institute of Clinical and Experimental Medicine
2021
San Diego Cardiac Center
2020
National Nuclear Center of the Republic of Kazakhstan
2016-2018
The drive-line to power contemporary ventricular assist devices exiting the skin is associated with infection, and requires a holstered performance of cardiac pump, which reduces overall quality life. Attempts eliminate using transcutaneous energy transfer systems have been explored but not succeeded in viable widespread application. unique engineering coplanar system characterized by 2 large rings utilizing coil-within-the-coil topology, ensuring robust resonance while allowing for...
Coagulation parameters are important determinants for COVID-19 infection. We conducted meta-analysis to assess the association between early hemostatic and infection severity.Electronic search was made papers that addressed clinical characteristics of patients disease severity. Results were filtered using exclusion inclusion criteria then pooled into a estimate standardized mean difference (SMD) with 95% confidence interval (CI) D-dimers, fibrinogen, prothrombin time, platelet count (PLT),...
Recent studies highlight the crucial role of gut microbiome in post-infectious complications, especially patients recovering from severe COVID-19. Our research aimed to explore connection between changes and cytokine profile with post-COVID syndrome. Using 16S rRNA amplicon sequencing, we analyzed composition 60 COVID-19 over course one year. We also measured levels serum cytokines chemokines using Milliplex system. results showed that SARS-CoV-2 infection cases, those complicated by...
Low vitamin D status is linked to disturbance in cognitive performance. This study explored possible ways how composition and functional capacity of the gut microbiome affects metabolism, directing serum (VitD) levels memory impairmets. It was found that composition, characterized by an increase relative abundance Enterococcus correlated with deficiency and, as consequence, impairments. A key mechanism identified differential utilization short-chain fatty acids (SCFAs) produced bacteria...
<sec> <title>BACKGROUND</title> The acute effect of hemodialysis (HD) on left ventricular mechanics has been evaluated in several studies, however their results are not consistent. Eventually, the heart and arterial system behave as an interconnected isolated structures; thus, evaluation interaction cardiac contractility with would provide a more comprehensive understanding cardiovascular function energetics. However, there have any studies demonstrating changes terms volumes, contractility,...
We present the findings from an evaluation of 144 survivors who experienced post-COVID-19 complications or reinfection. The assessment was conducted at 1, 3, and 6 months following their discharge intensive post-COVID care center. encompassed a comprehensive analysis clinical life-critical indicators mental health states. Based on lung CT scans, pneumonia identified in 73% patients, categorized into four severity groups according to conditions: mild (26%), moderate (57%), severe (14%),...
Abstract Background. Atherosclerosis, a major cause of cardiovascular disease, has significant impact on morbidity and mortality in Kazakhstan. The increasing burden this combined with high prevalence dyslipidemia, underscores the importance effective screening to reduce associated health risks. aim study is evaluate social efficiency implementing nationwide atherosclerosis program Kazakhstan assess its potential improve public outcomes from disease. Methods. A literature review was...
Annotation Background. The aim of this study was to investigate the relationship between Apolipoprotein B/Apolipoprotein A1 ratio and risk metabolically associated fatty liver disease, considering lipid profile variations determine whether can serve as an independent predictor disease its cardiovascular risks. Methods. A total 377 patients diagnosed with coexisting were stratified into high-risk very groups based on established clinical imaging criteria. Lipid profiles, B, levels measured,...
Carmat bioprosthetic total artificial heart (Aeson; A-TAH) is a pulsatile and autoregulated device. The aim of this study to evaluate level hemolysis potential acquired von Willebrand syndrome after A-TAH implantation.We examined the presence in adult patients receiving support (n=10) during their whole clinical follow-up comparison with control subjects Heartmate II or III support. We also performed fluid structure interaction model coupled computational dynamics simulation resulting shear...
The CARMAT-Total Artificial Heart (C-TAH) is designed to provide heart replacement therapy for patients with end-stage biventricular failure. This report details the reliability and efficacy of autoregulation device control mechanism (auto-mode), mimic normal physiologic responses changing patient needs. Hemodynamic data from a continuous cohort 10 implanted device, recorded over 1,842 support days in auto-mode, were analyzed respect daily C-TAH uses embedded pressure sensors regulate pump...
Abstract Background Organ Care System (OCS) minimizes the cold ischemic time and allows for optimization of logistics meticulous recipient preparation. Impact normothermic ex-vivo preservation using OCS compared with storage (CS) prolonged heart especially beneficial high-risk recipients bridged to transplantation Mechanical Circulatory Support (MCS). Methods Between 2012 2018, we performed a retrospective single-center review prospectively collected data. All patients who underwent MCS...
The in-depth epidemiology of hypertension has not been studied in Kazakhstan (KZ) yet. We aimed to investigate the crude; age and sex standardized prevalence, incidence, all-cause mortality rate among hypertensive patients using a large-scale Unified National Electronic Health System (UNEHS) for period 2014-2019. Hypertension was defined based on ICD-10 codes (ICD-code: I10; I11; I12; I13). Of 1,908,419 patients, 1,186,706 (62.18%) were females 721,713 (37.82%) males. majority (56.3%) ethnic...
Abstract Aims The need for the left ventricular assist devices (LVAD) in patients with end‐stage heart failure is well established, but prior to 2011, this was not available Kazakhstan. We describe development of sole LVAD programme context a nascent transplantation and clinical outcomes first three years. Methods results From November 2011 2014, 146 underwent implantation 152 VADs (approximately 50 implanted per year). retrospectively analyzed data from 135 who received HeartMate II ( n =...
Nowadays, direct oral anticoagulants (DOACs) are the first-line anticoagulant strategy in patients with non-valvular atrial fibrillation (NVAF). We aimed to identify influence of polymorphisms genes encoding P-glycoprotein (ABCB1) and carboxylesterase 1 (CES1) on variability plasma concentrations DOACs Kazakhstani NVAF. analyzed rs4148738, rs1045642, rs2032582 rs1128503 ABCB1 rs8192935, rs2244613 rs71647871 CES1 measured dabigatran/apixaban biochemical parameters 150 NVAF patients....
The article focuses on the prevalence of circulatory diseases, organization and implementation new programs in system cardiological care services Republic Kazakhstan. Currently, three key are functioning at republican level: “Acute coronary syndrome”, “Chronic heart failure”, “Atherosclerosis dyslipoproteinemia”. National Scientific Cardiac Surgery Center (Astana) is coordinator all these programs.
ABSTRACT This study provides a comprehensive assessment of how urban-rural divides influence gut microbial diversity and composition across the distinct geographical landscapes Kazakhstan, elucidating intricate interplay between lifestyle, environment, microbiome. In this prospective cohort study, we enrolled 651 participants from urban centers rural settlements following ethical approval informed consent. Comprehensive demographic, dietary, stool sample data were collected. 16S rRNA gene...