A5004975894- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Cardiac electrophysiology and arrhythmias
- Lipoproteins and Cardiovascular Health
- Cardiac pacing and defibrillation studies
- Heart Failure Treatment and Management
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrest and Resuscitation
- Cholesterol and Lipid Metabolism
- GDF15 and Related Biomarkers
- Congenital heart defects research
- Cardiac Arrhythmias and Treatments
- Blood Coagulation and Thrombosis Mechanisms
- Orthopaedic implants and arthroplasty
- Cardiovascular Health and Risk Factors
- RNA modifications and cancer
- Cardiovascular Effects of Exercise
- Cardiac Ischemia and Reperfusion
- Healthcare Systems and Public Health
- Biotechnology and Related Fields
- Fuel Cells and Related Materials
- Protein Kinase Regulation and GTPase Signaling
- Atherosclerosis and Cardiovascular Diseases
- Genetics and Neurodevelopmental Disorders
- Erythrocyte Function and Pathophysiology
Nazarbayev University
2016-2024
L. N. Gumilyov Eurasian National University
2020-2023
University of Chicago
2021
Nowadays, direct oral anticoagulants (DOACs) are the first-line anticoagulant strategy in patients with non-valvular atrial fibrillation (NVAF). We aimed to identify influence of polymorphisms genes encoding P-glycoprotein (ABCB1) and carboxylesterase 1 (CES1) on variability plasma concentrations DOACs Kazakhstani NVAF. analyzed rs4148738, rs1045642, rs2032582 rs1128503 ABCB1 rs8192935, rs2244613 rs71647871 CES1 measured dabigatran/apixaban biochemical parameters 150 NVAF patients....
Left ventricular assist device (LVAD) implantation is one of the mechanical circulatory support (MCS) treatments for advanced heart failure (HF) patients. MCS has emerged as a lifesaving therapy that improves patients' quality life. However, remains limited by paradoxical coagulopathy accompanied thrombosis and bleeding. The mechanisms are increasingly being defined, but MCS-related bleeding, which related to shear-mediated alteration platelet function, poorly understood. Complications might...
The left ventricular assist device (LVAD) is one of the alternative treatments for heart failure (HF) patients. However, LVAD support followed by thrombosis, and bleeding complications which are caused high non-physiologic shear stress antithrombotic/anticoagulant therapy. A risk occurs in presence genotype polymorphisms involved coagulation system, hemostasis function metabolism aim study was to investigate influence single-nucleotide (SNP) HF patients with complications. We analyzed 21...
Clonal hematopoiesis (CH) is the increase in somatic clones carrying mutations hematopoietic stem cells. This biological condition can lead to cancer and implicated development of atherosclerosis cardiovascular diseases. CH indeterminate potential (CHIP) refers genes that are associated with Coronary heart disease (CHD) leukemia. Now, next-generation sequencing, we detect even if they present only a small number cells tissue sample being studied. Consequently, numerous studies have shown...
Familial hypercholesterolemia (FH) is a serious inherited disorder that can lead to early development of cardiovascular disease (CVD) due the high blood cholesterol levels. In our study, we identified in FH patient likely pathogenic variant LDLR and APOE genes. Interest homozygous state understandable given its rarity severe health consequences. The state, when both LDL receptor alleles mutated, demonstrates even higher levels an earlier more clinical course compared with heterozygous state....
Sudden cardiac death is an unexpected and often unpredictable event that can have serious consequences for the health lives of individuals not only in middle age but also young individuals. Mutations, particularly genes associated with cardiovascular disease, may play a main role development such events, their exact impact require detailed study prevention new mutations by using Next-generation sequencing (NGS). To evaluate diagnostic importance next-generation (NGS) our developed...
Introduction. Cardiac arrhythmias are the most common among group of cardiovascular diseases (CVD), and have a risk sudden cardiac death (SCD). Long QT syndrome (LQTS) is heritable disease characterized by prolongation interval on an electrocardiogram (ECG), which often leads to syncope SCD. Currently, identification mutations in ion channel genes patients with LQTS recognition genetic causes actual cardiology. Aim. To identify associated long Kazakhstani patients. Materials methods.This...
Familial hypercholesterolemia is an autosomal hereditary disease defined by increased level of low-density lipoprotein cholesterol (LDL-C), which predisposes significant risks for premature cardiovascular disorders. We present a family trio study: proband, 13-year-old Kazakh girl with homozygous familial (HoFH) and her parents. HoFH much more rare severe than heterozygous form the disorder. patients generally LDL-C levels exceeding 13 mmol/L, resulting in early life-threatening events within...
Background: Despite the high progress that has been made in field of cardiology, left ventricular assist device (LVAD) can still cause complications (thrombosis/bleeding) heart failure (HF) patients after implantation. Complications develop due to incorrect dose antithrombotic therapy, influence non-physiological shear stress device, and also inherited genetic polymorphisms. Therefore, aim our study is identify polymorphisms on complication development HF with implanted LVADs prescribed...
Introduction. Sitosterolemia is a rare genetic disorder directly associated with dysfunction of ABCG5 and G8 genes. The data obtained was used to analyze the cellular mechanisms role transporters in absorption excretion serum sterols. Thus, understand influence mutations on development cardiovascular disease. Aim. To investigate clinical manifestation between sitosterolemia familial hypercholesterolemia (FH), focusing how dysfunctions lead misdiagnosis as FH. Research Strategy.The collection...
Введение. Изучение клонального гемопоэза с неопределенным потенциалом (КГНП) и ее возможной связи ишемической болезнью сердца (ИБС) представляет собой активно развивающуюся область научных исследований в медицине. КГНП относится к явлению возникновения клеточных клонов кроветворной системы дальнейшей трансформации. Понимание между этим явлением развитием болезни имеет важное значение для выявления новых факторов риска разработки эффективных методов профилактики лечения данного заболевания....
Relevance. Left ventricular assist device (LVAD) is an alternative treatment for heart failure (HF) patients which improves patient’s quality of life at their end-stage. Despite to the improvement LVAD beleaguered with thrombosis/bleeding complications in 70% HF after implantation. An anticoagulant warfarin usually prescribed reduce thrombosis complications. However, due incorrect dosage thrombosis/ bleeding still happen. Warfarin dose could be identified by genetic variants vitamin...
Introduction.This review is devoted about the development of thrombosis and bleeding complications after implantation mechanical circulatory support (MCS) device in heart failure (HF) patients which could be treated by genotyping test results. Objective. To analyze literature clinical investigations cause their prevention genome-guided antithrombotic therapy according to results for genetic polymorphisms. Research strategy. Search scientific publications was carried out search engines such...
Введение. Хроническая сердечная недостаточность является одной из главных проблем здравоохранения Республики Казахстан, которая требует проведения трансплантации сердца (ТС) для продления жизни пациента. Пересадка не доступна каждому пациенту из-за ограниченного количества доноров сердца. На сегодняшний день альтернативным методом ТС имплантация вспомогательного механического устройства левого желудочка (left ventricular assist device, LVAD), помогает пациентам дожить до пересадки. Однако,...