A5050588730- Cardiac Arrhythmias and Treatments
- Cardiovascular Issues in Pregnancy
- Atrial Fibrillation Management and Outcomes
- Rheumatoid Arthritis Research and Therapies
- Acute Lymphoblastic Leukemia research
- Systemic Lupus Erythematosus Research
- Spondyloarthritis Studies and Treatments
- Cardiovascular Syncope and Autonomic Disorders
- Bipolar Disorder and Treatment
- Neurological Complications and Syndromes
- Cardiac pacing and defibrillation studies
- Electrolyte and hormonal disorders
- Cardiac electrophysiology and arrhythmias
- Chemotherapy-induced organ toxicity mitigation
- Ferrocene Chemistry and Applications
- Ocular Diseases and Behçet’s Syndrome
- Yersinia bacterium, plague, ectoparasites research
- Renal Transplantation Outcomes and Treatments
- Birth, Development, and Health
- Bariatric Surgery and Outcomes
- Coronary Interventions and Diagnostics
- Gut microbiota and health
- Methemoglobinemia and Tumor Lysis Syndrome
- Hematopoietic Stem Cell Transplantation
- Inflammatory Bowel Disease
Astana Medical University
2020-2024
Nazarbayev University
2024
This study aimed to identify the oral microbial signature of Kazakh female rheumatoid arthritis (RA) patients. A total 75 patients who met American College Rheumatology 2010 classification criteria for RA and 114 healthy volunteers were included in study. Amplicons 16S rRNA gene sequenced analyze composition. We identified significant differences bacterial diversity abundance between control groups, as measured by Shannon (p value = 0.0205) Simpson 0.00152) indices. The samples from had...
Nowadays, direct oral anticoagulants (DOACs) are the first-line anticoagulant strategy in patients with non-valvular atrial fibrillation (NVAF). We aimed to identify influence of polymorphisms genes encoding P-glycoprotein (ABCB1) and carboxylesterase 1 (CES1) on variability plasma concentrations DOACs Kazakhstani NVAF. analyzed rs4148738, rs1045642, rs2032582 rs1128503 ABCB1 rs8192935, rs2244613 rs71647871 CES1 measured dabigatran/apixaban biochemical parameters 150 NVAF patients....
Objective The primary objective is to study the impact of gut microbiota and their interactions with diverse immunological markers on development rheumatoid arthritis. Methods This was performed in Astana, Kazakhstan, included 77 Kazakh female patients older than 18 years, who met American College Rheumatology 2010 classification criteria for arthritis (RA), 113 healthy controls. DNA extracted from fecal samples obtained all participants subsequent sequencing at 16S rRNA gene V1-V3 locus,...
Abstract Background Arrhythmias can occur during gestation. The data of peculiarities development and manifestations arrhythmias in pregnant women are limited. Purpose To determine the diagnostic clinic with arrhythmias. Methods In this single-center, prospectively study we consequently included 87 cases (mean age 26.7±3.5 years, mean gestation 24.6 ±3.3 weeks). main types clinical were studed. Results 56% cases, arrhythmia firstly occurred current most common symptoms occured second...
Abstract Background Although arrhythmia is common cardiac complication during gestation, data on perinatal and neonatal outcomes in pregnant women with different management limited. Purpose To explore clinical characteristics of strategies arrhythmias. Methods In this single-center, prospectively study we consequently included 87 cases arrhythmias (mean age 26.7±3.5 years, mean gestation 24.6 ±3.3 weeks). Clinical characteristics, obstetric were compared due to strategies: dynamic...
Abstract Background Arrhythmias are common during gestation. While the safety and effectiveness of zero-fluoroscopy arrhythmias catheter ablation has been studied, effects it in pregnant poorly understood. Purpose The aim our single-center, prospectively study is explore feasibility, efficacy pregnant. Methods Characteristic, obstetric neonatal outcomes 47 cases gestation (main group) within 24 month follow-up were compared with group antiarrhythmic therapy (control group, p=54). Ablation...
Abstract Background The latest data of effectiveness and safety catheter ablation without using fluoroscopy in general population suppose wide this technology. However, on pregnant is limited. Purpose To investigate efficacy women with analyzing obstetric neonatal outcomes. Methods We studied 47 cases (mean age 25.3±3.9 years, mean gestation 23.7 ±3.1 weeks) within 24 month follow-up. Ablation was performed under the guidance CARTO (n=21; 44.7%) Ensite Precision systems (n=26; 55.3%) all...
Abstract Background Although recommended avoid any intervention during gestation in cases of drug refractory arrhythmias catheter ablation may be necessary pregnant women. Purpose To present clinical characteristics and outcomes zero-fluoroscopy gestation. Methods This prospective, single center study included 84 tachyarrhythmias In 44 was performed without fluoroscopy (main group). We evaluated the further course obstetric after comparison with antiarrhythmic therapy (n=40, control Results...
Abstract Funding Acknowledgements Type of funding sources: None. Background Despite the incidence arrhythmias in pregnancy data on non-fluoroscopic catheter ablation pregnant women and perinatal outcomes is limited. Purpose aim this study to prospectively assess efficacy safety with arrhythmias. Methods 44 (mean age 28,2 ± 4,2 years, mean gestation 24,4 ±3,8 weeks) indicated for were enrolled. The was performed under guidance CARTO (n = 20; 45%) Ensite Precision systems 24; 55%) without...
The material describes the event on discussion and adoption of National Consensus metabolic surgery in type 2 diabetes mellitus.For first time Republic Kazakhstan, thanks to interaction between endocrinologists bariatric/metabolic surgeons, a joint for was adopted. document focuses approval indications, contraindications, choice surgical treatment method, as well criteria evaluating results surgery. creation will allow unified interpretation diagnostic therapeutic approaches this socially...
Abstract Background Although recommended avoid any intervention during gestation in cases of poor tolerance to high degree atrioventricular block, pacemaker implantation may be necessary pregnant women. Purpose To present outcomes gestation. Methods This prospective, single center study included 10 (median age patient - 26 years old at 18 weeks gestation). We evaluated the further course and obstetric after comparison with tachyarrythmias (n=111). Results Among 121 women varying arrhythmias...
Актуальность. Анкилозирующий спондилоартрит (АС) является хроническим системным воспалительным заболеванием осевого скелета и илеосакральных сочленений, которое преимущественно выявляется у лиц мужского пола. Однако, по данным последних публикаций выявлено увеличение частоты заболевания среди пациентов женского Поэтому изучение фенотипических особенностей в зависимости от пола актуальной проблемой современной ревматологии. Цель: гендерных течение пациентов, страдающих анкилозирующим...
Introduction. Rheumatoid arthritis (RA) is an autoimmune disease of unknown etiology that leads to disability due articular and extra-articular damage. RA prevalence variable. The most common among females with a 3 : 1 ratio. interaction environmental host factors contributes development. Currently, the genome-wide association studies (GWAS) give opportunity uncover genetic background. Anticitrullinated peptide antibody (ACPA) highly specific antibody, associated poor prognosis severe course...
BACKGROUND: The prevalence of rheumatoid arthritis (RA) is 1% in the global population. lack epidemiological studies developing countries makes it difficult to obtain a complete picture RA. RA develops due interaction multiple genetic and environmental factors, though contribution these factors various disease occurrence seen different populations unclear. AIM: aim our study was analyze dynamics general incidence among population Kazakhstan 2017–2019 as well investigate three most common...
BACKGROUND: Hematopoietic Stem Cell Transplantation (HSCT) has recently been a widely used method of therapy in various fields current medicine, particularly hematology.Some patients develop renal disorders following HSCT. AIM: This study aims to evaluate the dynamics changes functional state kidneys with ALL after METHODS: In period from 2015 2021, for first time Kazakhstan, acute lymphoblastic leukemia (ALL) who underwent allogeneic and haploidentical HSCT were prospectively examined....
Relevance: Acute renal kidney injury is a severe complication in patients with acute leukemia who underwent hematopoietic stem cell
 transplantation (HSCT). According to statistics, dysfunction often occurs the first 100 days after HSCT.
 This study aimed evaluate function cell transplantation.
 Methods: The article presents clinical cases of lymphoblastic developed failure after
 HSCT. dynamics functional state kidneys HSCT are described.
 Results: disorder studied...
BACKGROUND: Rheumatoid arthritis (RA) prevalence according to the worldwide epidemiological data varies from 0.4% 1.3%. The disability and mortality rate in RA is high. clinic various, compiles articular systemic manifestations. AIM: aim of our study was investigate clinical course Kazakhstani patients living North region country. METHODS: 81 women at age 30–55 years with a verified diagnosis who have lived Kazakhstan for least 10 were recruited study. All participants examined by...
Abstract Funding Acknowledgements Type of funding sources: None. Background Although bradyarrhythmias may occur in pregnant patients, there are few data on their management, pregnancy course and perinatal outcomes. Purpose To evaluate the effects outcomes pregnancy. Methods This single-center, prospective study included 8 cases complete atrioventricular block patients (Mean age was 25.4±3.6 years, mean gestation 17.6 ±2.4 weeks). All were without structural heart disease. Pregnancy course,...