A5073106374- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Probiotics and Fermented Foods
- Psoriasis: Treatment and Pathogenesis
- Digestive system and related health
- Tryptophan and brain disorders
- Rheumatoid Arthritis Research and Therapies
- Salivary Gland Disorders and Functions
- Oral microbiology and periodontitis research
- Proteins in Food Systems
- Animal Diversity and Health Studies
- Microscopic Colitis
- Systemic Lupus Erythematosus Research
- Mycobacterium research and diagnosis
- Dermatology and Skin Diseases
- Biochemical and Structural Characterization
- Escherichia coli research studies
- Obesity, Physical Activity, Diet
- Monoclonal and Polyclonal Antibodies Research
- Dialysis and Renal Disease Management
- Biomarkers in Disease Mechanisms
- Diet and metabolism studies
- Nuts composition and effects
- Erythropoietin and Anemia Treatment
- Galectins and Cancer Biology
Nazarbayev University
2019-2025
L. N. Gumilyov Eurasian National University
2024
Kazakh National Medical University
2023
Recent studies have suggested that periodontal disease and alterations in the oral microbiome may be associated with cognitive decline Alzheimer’s (AD) development. Here, we report a case-control study of microbiota diversity AD patients compared to healthy seniors from Central Asia. We characterized bacterial taxonomic composition (n = 64) group 71) using 16S ribosomal RNA sequencing. According our results, has higher microbial diversity, an increase Firmicutes decrease Bacteroidetes group....
Background: Psoriasis is a chronic inflammatory condition that predominantly affects the skin and associated with extracutaneous disorders, such as bowel disease arthritis. Changes in gut immunology microbiota are important drivers of proinflammatory disorders could play role pathogenesis psoriasis. Therefore, we explored whether psoriasis Central Asian cohort alterations select immunological markers and/or gut. Methods: We undertook case-control study stool samples collected from...
Low vitamin D status is linked to disturbance in cognitive performance. This study explored possible ways how composition and functional capacity of the gut microbiome affects metabolism, directing serum (VitD) levels memory impairmets. It was found that composition, characterized by an increase relative abundance Enterococcus correlated with deficiency and, as consequence, impairments. A key mechanism identified differential utilization short-chain fatty acids (SCFAs) produced bacteria...
Abstract Doxorubicin is a chemotherapeutic agent known to cause cardiotoxicity that thought be associated with oxidative stress. The aim of the current study investigate role grape polyphenols’ antioxidant property as cardioprotective against doxorubicin-induced cardiotoxicity. Adult Wistar rats weighing 200 ± 20 g were divided into 3 different groups: doxorubicin group received single intraperitoneal administration (8.0 mg/kg body weight), an experimental and polyphenol concentrate (25...
The longevity is influenced by genetic, environmental, and lifestyle factors. specific changes that occur in the gut microbiome during aging process, their relationship to immune function, have not yet been fully understood. ongoing research of other based on cohort Kazakhstan provides preliminary information longevity-related aging, where cytokine expression associated with microbial communities functions.
Recent studies highlight the crucial role of gut microbiome in post-infectious complications, especially patients recovering from severe COVID-19. Our research aimed to explore connection between changes and cytokine profile with post-COVID syndrome. Using 16S rRNA amplicon sequencing, we analyzed composition 60 COVID-19 over course one year. We also measured levels serum cytokines chemokines using Milliplex system. results showed that SARS-CoV-2 infection cases, those complicated by...
Exosomes are cell-derived, membrane-surrounded particles that deliver bioactive molecules to various cells. Due their small size, low immunogenicity, extended blood circulation, and involvement in cellular communication, they hold potential as effective drug carriers. present biological fluids, including mare's milk, a traditional drink Central Asia. This study aims compare exosome isolation methodologies determine the stability of milk-derived exosomes therapeutic Three extraction...
This study aimed to identify the oral microbial signature of Kazakh female rheumatoid arthritis (RA) patients. A total 75 patients who met American College Rheumatology 2010 classification criteria for RA and 114 healthy volunteers were included in study. Amplicons 16S rRNA gene sequenced analyze composition. We identified significant differences bacterial diversity abundance between control groups, as measured by Shannon (p value = 0.0205) Simpson 0.00152) indices. The samples from had...
ABSTRACT This study provides a comprehensive assessment of how urban-rural divides influence gut microbial diversity and composition across the distinct geographical landscapes Kazakhstan, elucidating intricate interplay between lifestyle, environment, microbiome. In this prospective cohort study, we enrolled 651 participants from urban centers rural settlements following ethical approval informed consent. Comprehensive demographic, dietary, stool sample data were collected. 16S rRNA gene...
Objective The primary objective is to study the impact of gut microbiota and their interactions with diverse immunological markers on development rheumatoid arthritis. Methods This was performed in Astana, Kazakhstan, included 77 Kazakh female patients older than 18 years, who met American College Rheumatology 2010 classification criteria for arthritis (RA), 113 healthy controls. DNA extracted from fecal samples obtained all participants subsequent sequencing at 16S rRNA gene V1-V3 locus,...
Introduction Probiotics and prebiotics are widely used for recovery of the human gut microbiome after antibiotic treatment. High usage is especially common in children with developing microbiome. We hypothesized that dry Mare’s milk, which rich biologically active substances without containing live bacteria, could be as a prebiotic promoting microbial diversity following treatment children. The present pilot study aims to determine impacts milk on bacterial communities when administered...
The aim of this study is determine the in vitro and vivo antiradical properties cytoprotective activity Allium nutans L. honey extract. extracts were investigated rabbit alveolar macrophages human foreskin fibroblast (hFFs) cells presence doxorubicin, a cytotoxic substance using DPPH ABTS assays. activities determined 18 Wistar rats divided into three different groups, negative control, two other groups with experimentally induced hepatotoxicity by single intraperitoneal injection 50% carbon...
Several studies reveal that the phenolic compounds present in wine and their concentrations determine physiological activities of red wine. In this study, main polyphenol components, including hydroxycinnamic acids, flavones, flavan-3-ols stilbenoids, were investigated via HLPC-UV “Cabernet Sauvignon” “Saperavi” wines selected from different regions years. assistance a meta-analysis, we found there are no fundamental differences between Cabernet Sauvignon Saperavi. However, amounts several...
Inflammatory bowel disease is one of the serious burdens clinical medicine and healthcare. This study investigated potential a biological product based on mare's milk metabolites symbiotic microflora for modulation intestinal affected by dextran sulfate sodium (DSS)-induced dysbiosis. Symbiotic was isolated from stool healthy volunteers. Lysates production short-chain fatty acids screened microorganisms were mixed with milk. The activity evaluated DSS model induced colitis. Histological...
The purposes of this study were to research immune system changes and liver lung tissues in irradiated rats after prolonged exposure coal dust. A was carried out on 30 male Wistar that divided into 3 groups: group I, intact animals; II, dust 0.2 Gy γ-irradiation; III, combined 6 γ-irradiation combination a low sublethal dose with leads significant change immunity at the remote period. Particularly, increase radioactivity effect causes weakening phagocytosis, reduction T lymphocytes by factor...
Ulcerative colitis is an inflammatory bowel disease that forms ulcerations in the mucous membrane of colon and rectum, which gut microbiota plays a pivotal role its pathogenesis. Agents modulating microbial dysbiosis caused by can help remission this disease. The current study describes potential therapeutic effects active metabolites from Lactobacillus rhamnosus mare's milk have values on intestinal proinflammatory cytokines. analysis V1-V3 16S rDNA site revealed significant changes...
Exosomes are cell derived and membrane-surrounded particles that deliver bioactive molecules to various cells. Their small size, low immunogenicity, extended blood circulation, involvement in cellular communication make them a potentially effective drug carrier. found different biological fluids including mare's milk, traditional drink central Asia. Therefore, the aim of this study is compare exosomes isolation methodology determine stability milk-derived as potential therapeutic Three...
Introduction: Dietary habits and eating patterns of individuals have a significant impact on overall health. Proper nutrition is vital to preventing chronic diseases improving physical mental performance. Kazakhstan, rapidly developing country in Central Asia, offers unique opportunity study the diverse dietary behavior its population due cultural, ethnic geographic differences. Purpose: nutritional status persons aged 18 years older various regions Kazakhstan. Materials methods: The was...
Abstract. Kozhakhmetov S, Babenko D, Nurgaziyev M, Tuyakova A, Nurgozhina Muhanbetganov N, Chulenbayeva L, Sergazy Gulyayev Saliev T, Kushugulova A. 2020. The combination of mare's milk and grape polyphenol extract for treatment dysbiosis induced by dextran sulfate sodium. Biodiversitas 21: 2275-2280. This study showed the potential a biological product based on complex polyphenols to modulate intestinal microflora after sodium (DSS)-induced dysbiosis. Rat ulcerative colitis has been...
Introduction. Rheumatoid arthritis (RA) is an autoimmune disease of unknown etiology that leads to disability due articular and extra-articular damage. RA prevalence variable. The most common among females with a 3 : 1 ratio. interaction environmental host factors contributes development. Currently, the genome-wide association studies (GWAS) give opportunity uncover genetic background. Anticitrullinated peptide antibody (ACPA) highly specific antibody, associated poor prognosis severe course...
BACKGROUND: The prevalence of rheumatoid arthritis (RA) is 1% in the global population. lack epidemiological studies developing countries makes it difficult to obtain a complete picture RA. RA develops due interaction multiple genetic and environmental factors, though contribution these factors various disease occurrence seen different populations unclear. AIM: aim our study was analyze dynamics general incidence among population Kazakhstan 2017–2019 as well investigate three most common...
Objective: Psoriasis is a chronic inflammatory condition that predominantly affects the skin and associated with extracutaneous disorders, such as bowel disease arthritis. Changes in gut immunology microbiota are important drivers of proinflammatory disorders could play role pathogenesis psoriasis. Therefore, we explored whether psoriasis Central Asian cohort alterations select immunological markers and/or gut. Setting: We assessed correlates community from Kazakhstan. Participants:...