Galina Fedotovskikh

ORCID: 0000-0003-2416-7385
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About
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Research Areas
  • Congenital Anomalies and Fetal Surgery
  • Parasitic infections in humans and animals
  • Amphibian and Reptile Biology
  • Systemic Sclerosis and Related Diseases
  • Dermatologic Treatments and Research
  • Antimicrobial Peptides and Activities
  • Medical and Biological Sciences
  • Amoebic Infections and Treatments
  • Myofascial pain diagnosis and treatment
  • Trauma, Hemostasis, Coagulopathy, Resuscitation
  • Blood transfusion and management
  • Neurobiology and Insect Physiology Research
  • Cancer-related cognitive impairment studies
  • Advanced Scientific Research Methods
  • Mesenchymal stem cell research
  • Parasitic Infections and Diagnostics
  • Thyroid Cancer Diagnosis and Treatment
  • Liver Disease and Transplantation
  • Venomous Animal Envenomation and Studies
  • Biomarkers in Disease Mechanisms
  • Oral Health Pathology and Treatment
  • Cardiac and Coronary Surgery Techniques
  • Urological Disorders and Treatments
  • Mast cells and histamine
  • melanin and skin pigmentation

National Medical Holding
2015-2020

National Scientific Center for Surgery named after A.N. Syzganov
2007-2020

Abstract Doxorubicin is a chemotherapeutic agent known to cause cardiotoxicity that thought be associated with oxidative stress. The aim of the current study investigate role grape polyphenols’ antioxidant property as cardioprotective against doxorubicin-induced cardiotoxicity. Adult Wistar rats weighing 200 ± 20 g were divided into 3 different groups: doxorubicin group received single intraperitoneal administration (8.0 mg/kg body weight), an experimental and polyphenol concentrate (25...

10.1038/s41598-020-71827-9 article EN cc-by Scientific Reports 2020-09-07

Serous cutaneous glands are described in newly metamorphosed and juvenile specimens of the horned frog Ceratophrys ornata using light transmission electron microscopy. We report patterns biosynthesis maturation specific product gland secretory unit. The syncytial, compartment possesses a complex endoplasmic reticulum (predominantly smooth after metamorphosis) Golgi stacks. serous is weak density contained vesicles involved repeating merging processes. During this activity, secondary...

10.1002/jmor.10541 article EN Journal of Morphology 2007-05-10

This study evaluates the feasibility of using high intensity focused ultrasound (HIFU) for treatment liver alveococcosis. HIFU ablation was carried out in 36 patients with alveococcosis liver. The median age 39.24±12, 93 years (range: 20-66 years). efficiency monitored real time morphological evaluation, computed tomography (CT), magnetic resonance imaging (MRI), (US), and cytological electron microscopy studies. has shown effectiveness destroying protoscolexes, laminar cell elements...

10.1016/j.ultsonch.2015.05.022 article EN cc-by-nc-nd Ultrasonics Sonochemistry 2015-05-27

15Oct 2016 THE IMPACT OF HIGH-INTENSITY FOCUSED ULTRASOUND ON HYDATID ECHINOCOCCUS CYST (EXPERIMENT IN VITRO). S. Imankulov , A. Baygenzhin K. Rustemova I. Tashev G. Fedotovskikh Shaimardanova N. Zhampeissov M. Erlan. National Scientific Medical Research center, Astana, Kazakhstan.

10.21474/ijar01/1801 article EN cc-by International Journal of Advanced Research 2016-10-21

After some clinical studies of the reproductive health female population Aral Sea region, we concluded that it is necessary to confirm by experiment theory direct influence dust-saline aerosols on system individuals.The purpose this work study effect folliculogenesis process in rats at inhalation intoxication.Inhalation was carried out for 30 days 4 hours a day 5 week special inoculating cylindrical chambers with extra-chamber placement animals individual boxes and dynamic aerosol delivery....

10.3889/oamjms.2018.240 article EN Open Access Macedonian Journal of Medical Sciences 2018-06-16

Aim: The purpose of morphological studies was to study pathogenetic mechanisms the therapeutic effect HIFU ablation on hepatic echinococcosis. Material and methods: Ablation echinococcal cysts alveococcal liver lesions no larger than 5 cm in size with high-intensity focused ultrasound performed JC Focused Ultrasound Therapeutic System (China). Biopsy material masses 37 patients after HIFU-ablation were taken for light-optical electron microscopic studies. Results: Protoscolexes lost their...

10.23950/jcmk/12285 article EN cc-by Journal of Clinical Medicine of Kazakhstan 2022-08-25

Introduction. The treatment of destructive inflammatory joint diseases (arthropathies) is one the issues current interest in modern medicine. In diseases, regenerative ability cartilaginous tissue proves to be inadequate for neogenesis joints. goal this study determine efficacy bone marrow-derived mononuclear cell fraction (MNC) and multipotent mesenchymal stromal cells (MMSC) diseases.Materials methods. subjects consisted 15 male rabbits weighing 3-4 kg with experimental knee disease. test...

10.5195/cajgh.2014.161 article EN cc-by Central Asian Journal of Global Health 2014-12-12

The pathologic evaluation of the liver is one most important issues in transplants. We evaluated histopathological condition livers potential donors.After biopsy, 37 donor were histologically studied. Liver tissue was stained by hematoxylin and eosin as well Masson Trichrome.The results study showed morphologic criteria used to estimate state donors not only steatosis fibrosis, but other histologic criteria, such proteinosis, necrosis hepatocytes, endotheliitis central veins, inflammatory...

10.6002/ect.tdtd2015.o23 article EN Experimental and Clinical Transplantation 2015-11-01

Objective: To determine the morpho-functional state of bone marrow autologous cells at ultrastructural level. Material and Methods: For electron microscopic examination, taken from patients with autoimmune diseases were fixed in a 2.5% solution glutaraldehyde post fixation 1% osmium tetroxide, was performed according to conventional method enclosed epon. Ultrathin sections prepared on Leica ultramicrotome, contrasted lead citrate by Reynolds, examined an microscope called Libra 120 (C....

10.23950/1812-2892-jcmk-00536 article EN cc-by Journal of Clinical Medicine of Kazakhstan 2018-03-15

The article describes the clinical and morphological dynamics of systemic scleroderma diffuse form on background autologous bone marrow mesenchymal stem cells transplantation.The basis for transplantation was presence a high activity index autoimmune process (EScSG), expressed skin changes (dense edema, induration) resistance to immunosuppressive therapy.Transplantation at contributes clinically significant reduction or cupping induration, Raynaud's syndrome, improvement patient's quality...

10.23950/1812-2892-jcmk-00550 article EN cc-by Journal of Clinical Medicine of Kazakhstan 2018-10-01

The article describes the clinical and morphological dynamics of systemic scleroderma diffuse form on background autologous bone marrow mesenchymal stem cells transplantation. basis for transplantation was presence a high activity index autoimmune process (EScSG), expressed skin changes (dense edema, induration) resistance to immunosuppressive therapy. Transplantation at contributes clinically significant reduction or cupping induration, Raynaud’s syndrome, improvement patient’s quality...

10.23950/1812-2892-00550 article EN cc-by Journal of Clinical Medicine of Kazakhstan 2018-10-01

Usage of bone marrow mesenchymal stromal cells (MSCs) in human inflammatory bowel disease has proven its feasibility clinical studies.The purpose this work was to study morpho-functional state large intestine mucosa (LIM) at the term 10 months after a single infusion cultured vitro expanded (MSC) added standard therapy patients with ulcerative colitis (UC).

10.18620/ctt-1866-8836-2019-8-2-58-62 article EN Cellular Therapy and Transplantation 2019-06-28

Some promising clinical results of hematopoietic stem cell transplantation (HSCT) are reported in severe autoimmune diseases. When treating the patients with systemic scleroderma (SSD), histological evaluation skin fibrosis includes scoring myofibroblasts that associated excessive deposition extracellular matrix components. The aim our study was to evaluate morphological condition SSD before and after autologous bone marrow cells. Patients methods Twenty-eight were observed at National...

10.18620/ctt-1866-8836-2020-9-2-60-66 article EN Cellular Therapy and Transplantation 2020-07-30
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