A5006465659- Gut microbiota and health
- Crystallization and Solubility Studies
- Synthesis and biological activity
- Probiotics and Fermented Foods
- Synthesis and Characterization of Heterocyclic Compounds
- Tryptophan and brain disorders
- Synthesis and Reactions of Organic Compounds
- Clostridium difficile and Clostridium perfringens research
- Digestive system and related health
- Nutrition, Genetics, and Disease
- Wound Healing and Treatments
- Proteins in Food Systems
- Human Health and Disease
- Metabolism, Diabetes, and Cancer
- Drug-Induced Hepatotoxicity and Protection
- X-ray Diffraction in Crystallography
- Autophagy in Disease and Therapy
- Quinazolinone synthesis and applications
- Animal Diversity and Health Studies
- Mycobacterium research and diagnosis
- Silymarin and Mushroom Poisoning
- Pancreatic function and diabetes
- Hibiscus Plant Research Studies
- Enzyme function and inhibition
- Phytochemical and Pharmacological Studies
Nazarbayev University
2015-2025
KazMunayGas (Kazakhstan)
2025
National Center for Biotechnology
2022-2024
Independent Expert Consulting Board to Promote Scientific Research Activity in Kazakhstan
2017
The longevity is influenced by genetic, environmental, and lifestyle factors. specific changes that occur in the gut microbiome during aging process, their relationship to immune function, have not yet been fully understood. ongoing research of other based on cohort Kazakhstan provides preliminary information longevity-related aging, where cytokine expression associated with microbial communities functions.
Low vitamin D status is linked to disturbance in cognitive performance. This study explored possible ways how composition and functional capacity of the gut microbiome affects metabolism, directing serum (VitD) levels memory impairmets. It was found that composition, characterized by an increase relative abundance Enterococcus correlated with deficiency and, as consequence, impairments. A key mechanism identified differential utilization short-chain fatty acids (SCFAs) produced bacteria...
Abstract Objective The aim of the current review was collection and analysis information about tobacco heating system THS commercialized as IQOSTM technology in comparison with conventional cigarettes CC. Data Sources data performed help Pubmed database other relevant sources including websites official health regulating bodies e.g. FDA, WHO, Public Health England for articles published until 15 February 2018 that contained key phrases IQOS, systems THS, heat-not-burn, which were found to be...
Abstract Doxorubicin is a chemotherapeutic agent known to cause cardiotoxicity that thought be associated with oxidative stress. The aim of the current study investigate role grape polyphenols’ antioxidant property as cardioprotective against doxorubicin-induced cardiotoxicity. Adult Wistar rats weighing 200 ± 20 g were divided into 3 different groups: doxorubicin group received single intraperitoneal administration (8.0 mg/kg body weight), an experimental and polyphenol concentrate (25...
The current study aims to evaluate potential hepatoprotective effect of lingonberry, cranberry and blueberry polyphenols on carbon tetrachloride (CCL-4)-induced acute subacute liver injury in rats. A total 55 male Wistar rats, divided into six experimental control groups. With the exception negative group, all groups received an intraperitoneal injection CCl-4, twice a week for 14 days. An extract cranberry, positive control, silymarin were administered daily via intragastric route,...
This article reports on the synthesis of nine promising new 1,3,4-thiadiazole derivatives based 3-aminopyridones, containing various acidic linkers. The was carried out by cyclizing corresponding thiohydrazides 4a-c and anhydrides glutaric, maleic, phthalic acids upon heating in acetic acid solution. conducted bio-screening synthesized different linkers (butanoic, acrylic, benzoic acids) showed that they have significant inhibitory activity against α-glucosidase (up to 95.0%), which is 1.9...
Exosomes are cell-derived, membrane-surrounded particles that deliver bioactive molecules to various cells. Due their small size, low immunogenicity, extended blood circulation, and involvement in cellular communication, they hold potential as effective drug carriers. present biological fluids, including mare's milk, a traditional drink Central Asia. This study aims compare exosome isolation methodologies determine the stability of milk-derived exosomes therapeutic Three extraction...
On the basis of biologically active 3-aminopyridin-2(1 H )-ones, chemical modification derivatives corresponding monothiooxamides, thiohydrazides, and conjugated 1,3,4-thiadiazole has been carried out for first time.
To determine the antiproliferative and cytotoxic activities of Geranium Erodium species against human cancer noncancer cell lines, respectively.Twenty-one were extracted screened cancerous noncancerous lines.In a dose-response manner, G. glaberrimum, asphodeloides, E. brandianum leucanthum able, with variable potency, to inhibit cellular proliferation. Except for brandianum, all extracts induced autophagy in tumor cells similar levels that rapamycin; but, only apoptosis, likely through Bcl2...
Objective The primary objective is to study the impact of gut microbiota and their interactions with diverse immunological markers on development rheumatoid arthritis. Methods This was performed in Astana, Kazakhstan, included 77 Kazakh female patients older than 18 years, who met American College Rheumatology 2010 classification criteria for arthritis (RA), 113 healthy controls. DNA extracted from fecal samples obtained all participants subsequent sequencing at 16S rRNA gene V1-V3 locus,...
The current study aimed to investigate the potential antiproliferative activity of metformin, effective concentration range, and mechanism action.Human breast cancer cells, MCF-7 were treated with a serial dilution metformin (10-150 μM) for 24 48 h. Potential its ability in inducing cellular apoptosis autophagy also investigated.Metformin inhibited proliferation time dependent manner, 80 μM as most concentration. Compared nontreated induced significant levels apoptosis, which confirmed by...
The glucose-lowering drug metformin has been reported to have anticancer properties through unknown mechanisms. Other factors that may influence its potential include the glycemic status of patient. Therefore, objective this study is determine effect different glucose environments on antiproliferative potency and cellular mechanism action metformin. Human breast cancer cells, MCF-7, were incubated in low, normal, elevated, high treated with protein expression as well ability induce apoptosis...
The aim of this study is determine the in vitro and vivo antiradical properties cytoprotective activity Allium nutans L. honey extract. extracts were investigated rabbit alveolar macrophages human foreskin fibroblast (hFFs) cells presence doxorubicin, a cytotoxic substance using DPPH ABTS assays. activities determined 18 Wistar rats divided into three different groups, negative control, two other groups with experimentally induced hepatotoxicity by single intraperitoneal injection 50% carbon...
Inflammatory bowel disease is one of the serious burdens clinical medicine and healthcare. This study investigated potential a biological product based on mare's milk metabolites symbiotic microflora for modulation intestinal affected by dextran sulfate sodium (DSS)-induced dysbiosis. Symbiotic was isolated from stool healthy volunteers. Lysates production short-chain fatty acids screened microorganisms were mixed with milk. The activity evaluated DSS model induced colitis. Histological...
Currently, studies are being conducted on the possible role of cytoprotective effect biologically active substances in conditions cerebral hypoxia or cardiomyopathies. At same time, oxidative stress is considered one important mechanisms cellular cytotoxicity and a target for action cytoprotectors. The aim this study to search derivatives 3-(arylmethylamino)-6-methyl-4-phenylpyridin-2(1H)-ones. probability was assessed by measuring cell viability using two tests (with neutral red dye MTT...
The purposes of this study were to research immune system changes and liver lung tissues in irradiated rats after prolonged exposure coal dust. A was carried out on 30 male Wistar that divided into 3 groups: group I, intact animals; II, dust 0.2 Gy γ-irradiation; III, combined 6 γ-irradiation combination a low sublethal dose with leads significant change immunity at the remote period. Particularly, increase radioactivity effect causes weakening phagocytosis, reduction T lymphocytes by factor...
Ulcerative colitis is an inflammatory bowel disease that forms ulcerations in the mucous membrane of colon and rectum, which gut microbiota plays a pivotal role its pathogenesis. Agents modulating microbial dysbiosis caused by can help remission this disease. The current study describes potential therapeutic effects active metabolites from Lactobacillus rhamnosus mare's milk have values on intestinal proinflammatory cytokines. analysis V1-V3 16S rDNA site revealed significant changes...
Exosomes are cell derived and membrane-surrounded particles that deliver bioactive molecules to various cells. Their small size, low immunogenicity, extended blood circulation, involvement in cellular communication make them a potentially effective drug carrier. found different biological fluids including mare's milk, traditional drink central Asia. Therefore, the aim of this study is compare exosomes isolation methodology determine stability milk-derived as potential therapeutic Three...
Reactions with allyl-, acetyl-, and phenylisothiocyanate have been studied on the basis of 3-amino-4,6-dimethylpyridine-2(1
Introduction: Dietary habits and eating patterns of individuals have a significant impact on overall health. Proper nutrition is vital to preventing chronic diseases improving physical mental performance. Kazakhstan, rapidly developing country in Central Asia, offers unique opportunity study the diverse dietary behavior its population due cultural, ethnic geographic differences. Purpose: nutritional status persons aged 18 years older various regions Kazakhstan. Materials methods: The was...