A5059748251- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Yersinia bacterium, plague, ectoparasites research
- Monoclonal and Polyclonal Antibodies Research
- Osteomyelitis and Bone Disorders Research
- Heterotopic Ossification and Related Conditions
- Ocular Diseases and Behçet’s Syndrome
- Bone Tumor Diagnosis and Treatments
- Medical Imaging and Pathology Studies
- Health Systems, Economic Evaluations, Quality of Life
- Parathyroid Disorders and Treatments
- Spondyloarthritis Studies and Treatments
- Herpesvirus Infections and Treatments
- Bone health and treatments
- Psoriasis: Treatment and Pathogenesis
- Cancer Diagnosis and Treatment
Astana Medical University
2021-2022
Introduction. Rheumatoid arthritis (RA) is an autoimmune disease of unknown etiology that leads to disability due articular and extra-articular damage. RA prevalence variable. The most common among females with a 3 : 1 ratio. interaction environmental host factors contributes development. Currently, the genome-wide association studies (GWAS) give opportunity uncover genetic background. Anticitrullinated peptide antibody (ACPA) highly specific antibody, associated poor prognosis severe course...
BACKGROUND: Rheumatoid arthritis (RA) prevalence according to the worldwide epidemiological data varies from 0.4% 1.3%. The disability and mortality rate in RA is high. clinic various, compiles articular systemic manifestations. AIM: aim of our study was investigate clinical course Kazakhstani patients living North region country. METHODS: 81 women at age 30–55 years with a verified diagnosis who have lived Kazakhstan for least 10 were recruited study. All participants examined by...
This article presents a clinical case of 71-year-old woman with pathological fracture caused by Paget's disease. One the most common signs this disease is deformity skeleton, which develops over many years and noticeable in skull lower extremities. Pathological fractures are likely to occur femoral bones. The restructuring bone tissue not only adversely affects general condition patients but also their quality life psycho-emotional state since newly formed prone deformations due...
Psoriasis is one of the most common skin diseases. 30% patients with psoriasis may develop psoriatic arthritis, which can lead to complex joint deformity and early disability. In this case, it very important have an interdisciplinary approach in selective treatment arthritis using genetically engineered biological drugs. our article, we present a world literature review on use drugs describe clinical case effective basic treatment.
This article describes a case series of total joint replacement in 4 patients with systemic lupus erythematosus affecting the hip and knee joints. The average age at time arthroplasty was 34 years. All were female all received glucocorticosteroid therapy varying doses 5 to 10 mg per day. At debut system, median activity index points. In one patient, remission induced by mycophenolate mofetil, another, azathioprine. total, three performed for aseptic necrosis head more due severe...
This article presents a clinical case of 24-year-old man with progressive fibrodysplasia ossificans. The course the disease leads to severe functional disorders musculoskeletal system, disability patients and premature death, mainly at young age. There is no way prevent progression disease. Surgical removal ossificates only enhances processes ossification. A common cause death pulmonary infection due hypoventilation. In future, there hope for creation drug that blocks genetic mechanism...
Изучены особенности дебюта, спектр клинических пpоявлений и ассоциации генов HLA I класса у больныx с ББ. Обследован 21 пациент достоверным диагнозом ББ: 10 мужчин 11 женщин, средний возраст – 36 лет, средняя длительность ББ около 20 лет. Исследуемые пациенты были жителями северного региона Казахстана. Активность оценивали по индексу BDCAF (Behсet Disease Current Activity Form), тяжесть Сh. Zouboulis. Особенностями дебюта женщин афтозный стоматит язвы гениталий, поpажение глаз суставов. У...