Organ donation is a critical component of healthcare, yet rates in Kazakhstan remain low. Understanding the socio-demographic factors, knowledge levels, and perceived barriers influencing individuals' willingness to consent organ essential for developing effective interventions. This cross-sectional study surveyed 1,294 participants across Kazakhstan. The sample was predominantly female (78.3%), urban (79.4%), well-educated, with significant proportion having medical backgrounds. Data were...

Abstract Background. Atherosclerosis, a major cause of cardiovascular disease, has significant impact on morbidity and mortality in Kazakhstan. The increasing burden this combined with high prevalence dyslipidemia, underscores the importance effective screening to reduce associated health risks. aim study is evaluate social efficiency implementing nationwide atherosclerosis program Kazakhstan assess its potential improve public outcomes from disease. Methods. A literature review was...

Annotation Background. The aim of this study was to investigate the relationship between Apolipoprotein B/Apolipoprotein A1 ratio and risk metabolically associated fatty liver disease, considering lipid profile variations determine whether can serve as an independent predictor disease its cardiovascular risks. Methods. A total 377 patients diagnosed with coexisting were stratified into high-risk very groups based on established clinical imaging criteria. Lipid profiles, B, levels measured,...

Background. Bilirubin is a byproduct of the breakdown erythrocytes. levels can potentially serve as biomarker for cardiovascular risk assessment. In this study, we would be investigating most recent manuscripts, published in last 5 years, that studied association serum bilirubin level to atherosclerosis progression elicit how strongly low total prognose disease progression. Methods. Using Pubmed search engine, all articles included keywords “bilirubin” and “atherosclerosis” were retrieved....

Background. Non-alcoholic fatty liver disease and type 2 diabetes mellitus or impaired glucose tolerance are common diseases with a high risk of developing cardiovascular diseases, the leading cause disability death. Our aim is to develop new methods for screening, prevention, treatment in patients non-alcoholic disease, mellitus, tolerance. Methods methods. This study single-center, open-label, uncontrolled, diagnostic study. Between 2023 February 2024, 216 concomitant diabetes, were...

Background. Obesity has turned into a worldwide epidemic with increasing prevalence that is associated excess mortality and morbidity. risk factor for many diseases including cardiovascular disease, the leading cause of death worldwide. Aim study was conducted to evaluate association obesity dyslipidemia hypertension among patients low, medium high developing Materials methods. Cross-sectional at tertiary hospital in Astana, Kazakhstan. In total 216 participants included this study. Results....

Background. Chronic heart failure is a major global health issue. As complication of most cardiovascular diseases, it affects 4% the population. Heart transplantation gold standard in treatment patients with end-stage failure. Objective study was to evaluate early and long-term outcomes transplants performed at Center University Medical (Heart Center) over 10-year period. Materials methods. Cross-sectional conducted from 2012 2022, 86 orthotopic were Center. The analysis obtained results...

Introduction There is no consensus on the optimal concentration of lipoprotein(a) (Lp(a)) for risk atherosclerotic cardiovascular diseases (ASCVD) and aortic valve stenosis. In various clinical guidelines agreed documents, threshold level Lp (a) 30 mg/dl or 50 mg/dl. We estimated cut-off value associated with developing localizations atherosclerosis Central Asia, including Kazakhstani population. Methods This study was conducted at National Research Cardiac Surgery Center, Kazakhstan. 487...

Введение: Недавние исследования в области секвенирования РНК единичных клеток улучшили понимание структуры субпопуляции иммунных при атеросклерозе. С помощью новых технологий выявлены новые клеток, участвующих Кроме того, появился относительно распространенный и сильный фактор сердечно-сосудистого риска: клональный гематопоэз с неопределенным потенциалом, это процесс, который возникает вследствие увеличения концентрации соматических мутаций течение жизни образованием мутантных клонов...

Introduction. Established in 2021, the Lipid Clinic Network of Kazakhstan is dedicated to creating a global framework for consistent standards diagnosing, managing, and treating lipid disorders, guided by European Society Cardiology Atherosclerosis (further - ESC/EAS) Guidelines on dyslipidaemia management. The aim evaluate pillars LCN assess feasibility dyslipidemia clinics implementation atherosclerosis project Kazakhstan. Materials methods. This cross-sectional survey with 8 questions...

Introduction: Kidney transplantation recognized as the most effective treatment for children with end-stage renal disease (ESRD), offering significant improvements in quality of life and long-term survival. Traditional methods detecting AR primarily involve invasive biopsy procedures that, while diagnostic, carry risks, especially pediatric patients. Therefore, there is an urgent need safer, less more patient-friendly to monitor graft health. Metabolomics, comprehensive analysis...

Introduction. Kidney transplantation is the only radical method of treating most terminal stages chronic renal failure. Acute rejection transplanted kidney one main and frequently encountered complications in recipients, occurring a few days or months after transplantation, whether from living deceased donor, as manifestation body's immune response to foreign tissue. The aim review analyze current literature on diagnosis treatment transplant rejection, with focus acute hyperacute Search...