Organ donation is a critical component of healthcare, yet rates in Kazakhstan remain low. Understanding the socio-demographic factors, knowledge levels, and perceived barriers influencing individuals' willingness to consent organ essential for developing effective interventions. This cross-sectional study surveyed 1,294 participants across Kazakhstan. The sample was predominantly female (78.3%), urban (79.4%), well-educated, with significant proportion having medical backgrounds. Data were...

BACKGROUND Although critically ill pediatric patients can benefit from the use of sedation, it cause side effects and even iatrogenic complications. Since cannot adequately express intensity or location pain, discriminating their irritability agitation be more complicated than in adults. Thus, sedation therapy for children requires careful attention. AIM To evaluate association internal parental care protocol reduction intensive unit (PICU) postoperatively. METHODS This retrospective cohort...

Background: This post hoc analysis from the Coronary Drug Project (CDP) evaluated effects of niacin vs. placebo on incidence new onset type 2 diabetes mellitus (T2DM) and cardiovascular event rates in patients with normal impaired fasting glucose (IFG). Methods: The CDP was a randomised, placebo-controlled clinical trial lipid-modifying agents men previous myocardial infarction. Normoglycaemia IFG were defined as plasma (FPG) < 5.6 mmol/l FPG ≥ but 7.0 mmol/l, respectively. New T2DM by 1...

Background: Sepsis is a frequent cause of death in hospitalized patients and, detail, neonatal, pediatric, and adult intensive care units (ICUs). Severe sepsis has very poor prognosis. Indeed, the mortality rate varies between 30 70% during first 7–14 days. Despite timely appropriate therapy, prognosis severe too often negative. Therefore, new therapeutic resources are under investigation order to further improve Case series: Here, we reported three septic children whom used extracorporeal...

Introduction Around seventy percent of all childhood cancer patients suffer from severe pain. This pain can arise various sources, including tumors themselves, caused by metastasizing tumor cells or as the outcome therapy meant to deal with tumors. If managed inadequately, such lead many hazardous sequelae. However, there are extreme cases when does not respond standard treatment. For cases, regional anesthesia nerve blocks utilized utmost control measure. Blocks used treat in who no longer...

Objectives Vaccines are considered one of the most important inventions human history that enabled containment several infectious diseases. However, there is a global decrease in rate vaccination and an increase outbreaks vaccine-preventable The aims current study to determine childhood vaccine hesitancy its influencing factors Kazakhstan.Methods This cross sectional online-based was conducted between Sep until Nov 2019.Results A total 387 participants which 70% were females with majority...

For the first time in Kazakhstan, we have used a combined extracorporeal support, by including CytoSorb system continuous veno-venous hemofiltration an 8-month-old patient with body weight of 5600 g.The therapy session resulted reduction inflammation markers IL-6, S100, procalcitonin, and C-reactive protein. Simultaneously, level transaminases, creatine kinase, troponin were normalized, end hemodynamics stable there was no need for vasopressors, acid-base balance maintained, weaned from...

High-dose methotrexate (HDMTX) is likely to cause a number of side effects and manifest itself as hepatotoxicity, nephrotoxicity, mucositis, neurotoxicity. A several studies demonstrated the efficacy extracorporeal detoxification methods such plasma exchange, hemodialysis (HD), HD filtration, hemoperfusion for treatment MTX delayed clearance. However, none existing effective expected limited general implementation due procedure-related complication.Here, we report successful HA-230...

The Leiden Charter for Children in Hospital states that children hospital shall have the right to their parents or parent substitute with them at all times (European Association (EACH) 1988). In this report, technology chain implementation of patient's parent/guardian resident stay model (RSM) pediatric anesthesiology, resuscitation and intensive care unit (PARICU) was presented. aim report share experience improving patient safety transparency introducing active through a «double control»....

Abdominal wall relaxation is a rare complication of various surgical procedures or diseases, when the intercostal upper lumbar nerves are affected, and innervation muscles abdominal damaged. The result mass that can visually mimic ventral hernia. We present clinical case results literature review on this topic.

Background: Pediatric sepsis presents a severe risk to immunocompromised children, especially those with cancer or pre-existing conditions, posing significant threat their lives. Cytokine hemadsorption has emerged as promising therapeutic approach for managing and inflammatory conditions in critically ill patients. This innovative method involves eliminating pro-inflammatory cytokines from the bloodstream, targeting underlying hyper-inflammatory response often seen critical illnesses. Study...

Introduction: Kidney transplantation recognized as the most effective treatment for children with end-stage renal disease (ESRD), offering significant improvements in quality of life and long-term survival. Traditional methods detecting AR primarily involve invasive biopsy procedures that, while diagnostic, carry risks, especially pediatric patients. Therefore, there is an urgent need safer, less more patient-friendly to monitor graft health. Metabolomics, comprehensive analysis...

Despite a detailed study of the natural development congenital spinal deformity in an isolated hemivertebra and methods surgical correction this pathology, some issues remain unresolved. The age at which should be performed is controversial issue among specialists dealing with problem. aim work was to conduct comparative analysis results children kyphoscoliosis preschool primary school age.The involved 26 patients aged from 1 year 9 months years 6 (10 girls 16 boys) caused by hemivertebra....

<h3>Background</h3> The treatment of Rheumatoid Diseases (including RA, AS, PsA) has evolved in recent years with continued development and introduction subcutaneous (SC) TNF-alpha blockers. <h3>Objectives</h3> objective this study is to compare persistence among the available SC blocker: adalimumab (ADA), certolizumab (CDP), etanercept (ETA), or golimumab (GLM) by RD patients. <h3>Methods</h3> A retrospective cohort was conducted using data from National Swedish Prescription Patient...