A5028067012- Ubiquitin and proteasome pathways
- Microbial Metabolites in Food Biotechnology
- Food composition and properties
- Advanced Fluorescence Microscopy Techniques
- Protein Degradation and Inhibitors
- Probiotics and Fermented Foods
- PI3K/AKT/mTOR signaling in cancer
- PARP inhibition in cancer therapy
- Pharmacological Effects and Toxicity Studies
- Diet, Metabolism, and Disease
- Virus-based gene therapy research
- Microtubule and mitosis dynamics
- Lung Cancer Research Studies
- Anesthesia and Pain Management
- Cancer, Stress, Anesthesia, and Immune Response
- ATP Synthase and ATPases Research
- NF-κB Signaling Pathways
- Glycosylation and Glycoproteins Research
- Prostate Cancer Treatment and Research
- bioluminescence and chemiluminescence research
- RNA modifications and cancer
- Nausea and vomiting management
- Cancer Research and Treatments
- Ovarian cancer diagnosis and treatment
- Neuroendocrine Tumor Research Advances
University of California, Davis
2024-2025
Mike and Josie Harper Cancer Research Institute
2017
University of Notre Dame
2015-2017
Purdue University West Lafayette
2008-2014
Center for Cancer Research
2014
Protein–protein interactions are essential for maintaining cell structure and executing almost all cellular processes. Determination of where how each protein interacts with its partners provides significant insight into proteins' roles. Although several assays, such as FRET bimolecular fluorescence complementation (BiFC), have been developed widely used visualization identification in living cells, there is no simple convenient assay to visualize identify multiple complexes cells. Because...
// Christopher D. Suarez 1, 2 , Junmin Wu Sunil S. Badve 3 Joseph A. Sparano 4 William Kaliney and Laurie E. Littlepage 1 Department of Chemistry Biochemistry, University Notre Dame, IN 46556, USA Harper Cancer Research Institute, South Bend, 46617, Indiana School Medicine, Indianapolis, 46202, Montefiore Medical Center, Albert Einstein College Bronx, NY 10461, Correspondence to: Littlepage, email: laurie.littlepage@nd.edu Keywords: Zfp217/ZNF217; triciribine; chemoresistance;...
Abstract Breast cancer is the second leading cause of related deaths with an estimated 232,340 new cases and 39,620 in 2013. Despite 93% patients being diagnosed local or regional stage disease, most patient result from metastasis as a recurrent disease after development therapeutic resistance. Developing better understanding molecular mechanisms resistance critical to help identify novel therapeutics that overcome metastasis, resistance, death. We previously identified transcription factor...
Abstract When metastatic breast tumors do not respond to treatment (e.g., chemotherapy, endocrine therapy, and targeted therapies), ultimately the patient dies. Understanding molecular events that cause recurrence after identifying effective second third line therapies treat recurrent will significantly improve outcomes. We previously identified transcription factor ZNF217 (human)/Zfp217 (mouse) as a prognostic marker of poor outcome in cancer patients. is overexpressed other cancers, this...