A5072310894- Gut microbiota and health
- Microbial Metabolites in Food Biotechnology
- Food composition and properties
- Probiotics and Fermented Foods
- Nutritional Studies and Diet
- Diet, Metabolism, and Disease
- Biochemical Analysis and Sensing Techniques
- Child Nutrition and Water Access
- Infant Nutrition and Health
- Diet and metabolism studies
- Glycosylation and Glycoproteins Research
- Gold and Silver Nanoparticles Synthesis and Applications
- Metabolomics and Mass Spectrometry Studies
- Fermentation and Sensory Analysis
- Clostridium difficile and Clostridium perfringens research
- Nanomaterials and Printing Technologies
- Coconut Research and Applications
- CRISPR and Genetic Engineering
- Advanced Sensor and Energy Harvesting Materials
- Nutrition, Genetics, and Disease
University of California, Davis
2021-2025
Ateneo de Manila University
2018
Evidence is accumulating that perturbed postnatal development of the gut microbiome contributes to childhood malnutrition
Understanding how members of the human gut microbiota prioritize nutrient resources is one component a larger effort to decipher mechanisms defining microbial community robustness and resiliency in health disease. This knowledge foundational for development microbiota-directed therapeutics. To model bacteria glycans gut, germfree mice were colonized with 13 bacterial strains, including seven saccharolytic Bacteroidaceae species. Animals fed Western diet supplemented pea fiber. After...
Gold electrodes are important in some devices and certain applications where an inert, highly conductive feature is required. An aqueous gold nanoparticle (AuNP) ink suitable for inkjet printing was synthesized formulated using starch microwave-assisted heating. By varying the hydrolysis conditions of starch, size, yield, stability AuNP suspension can be controlled optimized to achieve a jettable ink. The formulation has very low loading only 1.75 wt % relative gold, forming stable ink,...
The molecular complexity of the carbohydrates consumed by humans has been deceptively oversimplified due to a lack analytical methods that possess throughput, sensitivity, and resolution required provide quantitative structural information. However, such information is becoming an integral part understanding how specific glycan structures impact health through their interaction with gut microbiome host physiology. This work presents detailed catalogue glycans present in complementary foods...
Alcohol soluble carbohydrates (ASCs) comprise one of the most abundant classes dietary carbohydrates. While it is generally accepted that form a healthy part diet, types and amounts consumed are source disagreement among practitioners. In particular, role ASCs, commonly referred to as free sugars, comprising range mono-, di-, oligosaccharides, an active area debate. These arguments likely arise from dearth chemical structures. Studies have implicated diets high in glucose, fructose, other...
Dietary fiber has long been known to be an essential component of a healthy diet, and recent investigations into the gut microbiome-health paradigm have identified as prime determinant in this interaction. Further, is now impact microbiome structure-specific manner, conferring differential bioactivities these specific structures. However, current analytical methods for food carbohydrate analysis do not capture important structural information. To address need, we utilized rapid-throughput...
Carbohydrates play essential roles in a variety of biological processes that are dictated by their structures. However, characterization carbohydrate structures remains extremely difficult and generally unsolved. In this work, de novo mass spectrometry-based workflow was developed to isolate structurally elucidate oligosaccharides provide sequence, monosaccharide compositions, glycosidic linkage positions. The approach employs liquid chromatography-tandem spectrometry (LC-MS/MS)-based...
Carbohydrates are the most abundant biomolecules in nature, and specifically, polysaccharides present almost all plants fungi. Due to their compositional diversity, polysaccharide analysis remains challenging. Compared other biomolecules, high-throughput for carbohydrates has yet be developed. To address this gap analytical science, we have developed a multiplexed, high-throughput, quantitative approach foods. Specifically, were depolymerized using nonenzymatic chemical digestion process...
Evidence is accumulating that perturbed postnatal development of the gut microbiome contributes to childhood malnutrition 1–4 . Designing effective microbiome-directed therapeutic foods repair these perturbations requires knowledge about how food components interact with alter its expressed functions. Here we use biospecimens from a randomized, controlled trial complementary prototype (MDCF-2) produced superior rates weight gain compared conventional ready-to-use supplementary (RUSF) in...
Advances in analytical chemistry now make it possible to analyze the monosaccharide composition of foods thereby expanding dietary assessment carbohydrates. We sought characterize diets consumed a healthy U.S. adult cohort (ClinicalTrials.gov Identifier: NCT02367287). Dietary records consisting two three Automated Self-Administered 24-hour Recalls (ASA24) were obtained from 341 participants USDA Nutritional Phenotyping Study which assessed adults balanced for age, sex, and BMI. recalls...