A5079012129- Mechanical Circulatory Support Devices
- Transplantation: Methods and Outcomes
- Cardiac Structural Anomalies and Repair
- Organ Transplantation Techniques and Outcomes
- Cardiac Ischemia and Reperfusion
- Fuel Cells and Related Materials
- Cardiac Arrest and Resuscitation
- Congenital Heart Disease Studies
- Cardiac pacing and defibrillation studies
- Organ Donation and Transplantation
- Cardiac, Anesthesia and Surgical Outcomes
- Global Healthcare and Medical Tourism
- Cardiac Valve Diseases and Treatments
Astana Medical University
2019-2025
Institute of Clinical and Experimental Medicine
2021
San Diego Cardiac Center
2020
National Research Center for Maternal and Child Health
2015
The CARMAT-Total Artificial Heart (C-TAH) is designed to provide heart replacement therapy for patients with end-stage biventricular failure. This report details the reliability and efficacy of autoregulation device control mechanism (auto-mode), mimic normal physiologic responses changing patient needs. Hemodynamic data from a continuous cohort 10 implanted device, recorded over 1,842 support days in auto-mode, were analyzed respect daily C-TAH uses embedded pressure sensors regulate pump...
Abstract Background Organ Care System (OCS) minimizes the cold ischemic time and allows for optimization of logistics meticulous recipient preparation. Impact normothermic ex-vivo preservation using OCS compared with storage (CS) prolonged heart especially beneficial high-risk recipients bridged to transplantation Mechanical Circulatory Support (MCS). Methods Between 2012 2018, we performed a retrospective single-center review prospectively collected data. All patients who underwent MCS...
Abstract Aims The need for the left ventricular assist devices (LVAD) in patients with end‐stage heart failure is well established, but prior to 2011, this was not available Kazakhstan. We describe development of sole LVAD programme context a nascent transplantation and clinical outcomes first three years. Methods results From November 2011 2014, 146 underwent implantation 152 VADs (approximately 50 implanted per year). retrospectively analyzed data from 135 who received HeartMate II ( n =...
Cold storage preservation is the standard approach for heart transplantation but a time-limited method of care. Ex vivo perfusion expands donor pool due by mitigating time and distance barriers allows possibility to improve graft function. We report long term follow up successful following an ex 17 h using Organ Care System in patient with left ventricular assist device.
Objectives Cold crystalloid cardioplegia for donor heart harvesting and cold ischemic storage conditions during the transportation is standard of care transplantation procedure. Organ system (OCS) was introduced more prolonged reliable ex vivo organ management. This study evaluated two different techniques used myocardial preservation procurement using OCS. Methods We performed prospective analysis 43 patients with failure undergoing OCS transport. Donor hearts were arrested blood...
In Kazakhstan, geographical and cultural reasons do not favor the development of heart transplant activity. Thus, a surgical program for treatment advanced, refractory failure was implemented, focusing efforts on ventricular assist device (VAD) therapy. The program, supported funded by national healthcare system, is based single, highly specialized Center operation, regional infrastructure outpatient follow-up. Regional VAD coordinators are educated National Center. They in charge regular...
Abstract Background: Organ Care System (OCS) minimizes the cold ischemic time and allows for optimization of logistics meticulous recipient preparation. Impact normothermic ex-vivo preservation using OCS compared with storage (CS) prolonged heart especially beneficial high-risk recipients bridged to transplantation Mechanical Circulatory Support (MCS). Methods: Between 2012 2018, we performed a retrospective single-center review prospectively collected data. All patients who underwent MCS...
As a consequence of limited donor availability, there has been growing interest for alternative strategies, such as left ventricular assist devices (LVAD) either bridge to transplantation (BTT) or destination therapy (DT) the treatment advanced heart failure. The transplant program in Kazakhstan is nascent stage and therefore patients that are determined be BTT expected have an extended duration LVAD support.
Background: The management of end-stage heart failure (HF) with transplantation (HTx) as the gold standard therapy relies on a long-term mechanical circulatory support (MCS) devices for bridging patients. This study aimed to analyze clinical outcomes HTx in bridge-to-transplant population Kazakhstan. Methods: In this retrospective, single-center we included 40 patients MCS who were transplanted Kazakhstan between 2014 and 2022. Results: Of 85 transplantations performed, (47%) bridged...
Background: The pulsatile Aeson Total Artificial Heart (TAH) employs embedded sensors to autoregulate the response of device changing patient needs. These are also used monitor Pulmonary Vascular Resistance (PVR) in patients supported by TAH whose major contraindication transplantation is an elevated PVR. efficacy this facility was evaluated during course a recent Bridge To Transplant study (NCT02962973). Methods: Pressure records from right and left ventricular pressure pump output...
Background: Continuous ex-situ machine perfusion has been proposed as an alternative and superior method of donor lungs preservation compared to cold static storage especially during the transport time. The emergence cardiac ex situ not only facilitates use lung through avoidance potentially damaging ischemia graft storage, it also opens new horizons for more sensitive monitoring quality in transplant field, morphologic-functional assessments. Methods: Twenty-five domestic adult pigs,...
Background: Heart transplantation remains the treatment of choice for patients experiencing end-stage heart failure. The emergence cardiac ex situ machine perfusion not only facilitates use donor through avoidance potentially damaging ischemia during graft storage, it also opens new horizons more sensitive monitoring quality in transplant field, and morphologic-functional assessment. Methods: Twenty-five domestic adult pigs, weighing 93.1±13.1kg were selected this study. Until cardiectomy,...
Left ventricular assist device (LVAD) outflow graft injury is a very rare complication after LVAD implantation and usually treated surgically. This case report of successful stenting the damaged 2.5 years implantation, followed by heart transplantation.
Background. Mechanical circulatory support (MCS) has been applied as an effective therapy for patients with end stage heart failure (HF). The existing donor organ shortage issue in Kazakhstan, and hence long waiting times, have resulted left ventricular assist device (LVAD) implantation being the predominant surgical treatment method this condition. purpose of study is to analyze clinical outcomes MCS program data our Center. Methods. This involves a retrospective analysis 324 different...
Abstract Background: Organ Care System (OCS) minimizes the cold ischemic time and allows for optimization of logistics meticulous recipient preparation. Impact normothermic ex-vivo preservation using OCS compared with storage (CS) prolonged heart especially beneficial high-risk recipients bridged to transplantation Mechanical Circulatory Support (MCS). Methods: Between 2012 2018, we performed a retrospective single-center review prospectively collected data. All patients who underwent MCS...
Background: We report a case of successful heart transplantation following donor resuscitation after 7 hours cold storage using ongoing recipient's cardiopulmonary bypass circuit prior to organ implantation in patient with left ventricular assist device. Methods: The was on LVAD support as bridge transplantation. patient's clinical status complicated by driveline infection influenced his necessitating urgent time ischemic already 430 minutes. Due the high risk graft failure and...
Timur Lesbekov, Zhuldyz Nurmykhametova, Rymbay Kaliyev, Linar Faizov, Assel Medressova, Marat Aripov, Eric Zuparov, Baurzhan Yuriy Pya. Korean J Transplant 2022;36:167. https://doi.org/10.4285/ATW2022.F-2926