A5091685793- Bone Tissue Engineering Materials
- Gut microbiota and health
- Neurological Disease Mechanisms and Treatments
- Diet and metabolism studies
- Mechanical Circulatory Support Devices
- Respiratory Support and Mechanisms
- Mesenchymal stem cell research
- Orthopaedic implants and arthroplasty
- Neuroinflammation and Neurodegeneration Mechanisms
- Dietary Effects on Health
- Neurogenesis and neuroplasticity mechanisms
- Bone health and osteoporosis research
- Periodontal Regeneration and Treatments
- Bone Metabolism and Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Tryptophan and brain disorders
- Regulation of Appetite and Obesity
- Inflammatory Biomarkers in Disease Prognosis
- Bone health and treatments
- Medical and Biological Sciences
- Cardiac Arrest and Resuscitation
- Titanium Alloys Microstructure and Properties
- Hydrogels: synthesis, properties, applications
- Plant chemical constituents analysis
- Arctic and Russian Policy Studies
Nazarbayev University
2015-2025
Abstract We have investigated the diversity and composition of gut microbiotas isolated from AD (Alzheimer's disease) patients (n = 41) healthy seniors 43) Nur-Sultan city (Kazakhstan). The microbiota was characterized by 16S ribosomal RNA sequencing. Our results demonstrated significant differences in bacterial abundance at phylum, class, order, genus levels compared to aged individuals. Relative analysis has revealed increased amount taxa belonging Acidobacteriota, Verrucomicrobiota,...
This study comprises the comprehensive toxicological assessment of thiolated organosilica nanoparticles (NPs) synthesised from 3-mercaptopropyltrimethoxysilane (MPTS). We investigated influence three different types 3-mercaptopropyltrimethoxysilane: starting silica (Si-NP-SH) and their derivatives prepared by surface PEGylation with PEG 750 (Si-NP-PEG750) 5000 Da (Si-NP-PEG5000m) on biological subjects in vitro to vivo experiments explore possible applications those biomedical research. As a...
The aim was to evaluate morphological effect of Cdc42 inhibition in mesenchymal stem cells (MSCs) on the restoration process bone defects during late post-traumatic period 24-months male rats with ulnar fractures. Material and methods . experiment involved adult Wistar (males, weighing 400–500 grams, aged 24 months; n=40) undergoing diaphysis osteotomy. After injury, animals were randomized into four groups (10 per group). Group I served as controls received no treatment. II administered...
Abstract Background The role of adiponectin (ADIPOQ) in Alzheimer’s disease (AD) has been documented, however, demonstrating controversial results. In this study, we investigated blood serum ADIPOQ levels, methylation the gene promoter, and receptors (AdipoR1 AdipoR2) expression samples isolated from AD patients healthy controls. Methods We performed a case–control study including 248 subjects (98 150 controls); AdipoR1, AdipoR2 levels PBMC were measured by ELISA Kits, was analyzed using...
Osteoporosis is a progressive systemic disease characterized by decrease in bone density. This leads to increased fragility and higher likelihood of fractures. New approaches cellular therapy have been developed for the effective treatment this pathology, based on use modified osteophilic polymers with mesenchymal stem cells (MSCs) local action damaged areas. The aim study was morphologically assess effectiveness polymer MSCs reparative osteogenesis processes during post-traumatic period...
Pathological bone fracturing is an escalating problem driven by increasing aging and obesity. Bioceramics, particularly tricalcium-phosphate-based materials (TCP), are renowned for their exceptional biocompatibility, osteoconductivity, ability to promote biomineralization. In the present study, we designed characterized TCP porous granules doped with strontium (Sr) copper (Cu) (CuSr TCP). Sr
Pericytes possess high multipotent features and cell plasticity, produce angiogenic neurotrophic factors that indicate their regenerative potential. The aim of this study was to investigate whether transplantation adipose-derived pericytes can improve functional recovery neurovascular plasticity after ischemic stroke in rats. Rat were isolated from subcutaneous adipose tissue by fluorescence-activated sorting. Adult male Wistar rats subjected 90 min middle cerebral artery occlusion followed...
Background: Pathological bone fracturing is an escalating problem driven by increasing aging and obesity. Bioceramics, particularly tricalcium-phosphate-based materials (TCP), are renowned for their exceptional biocompatibility, osteoconductivity, ability to promote biomineralization. In the present study, we designed characterized TCP porous granules doped with Strontium (Sr) Copper (Cu). Sr2+ ions were selected as it plays a crucial role in early formation, osteogenesis angiogenesis; Cu2+...
The objective of this work was to conduct pre-clinical feasibility studies determine if a highly efficient, active-mixing, adult extracorporeal carbon dioxide removal (ECCO 2 R) system can safely be translated the pediatric population. Hemolung Respiratory Assist System (RAS) tested in vitro and vivo evaluate its performance for veno-venous applications. RAS operates at blood flows 350-550 ml/min utilizes an integrated pump-gas exchange cartridge with membrane surface area 0.59 m as only...
There are numerous publications demonstrating that plant polyphenols can reduce oxidative stress and inflammatory processes in the brain. In present study we have investigated neuroprotective effect of extract isolated from roots L. gmelinii since it contains a rich source other biologically active compounds. We applied an model induced by NMDA, H2O2, TNF-α human primary neurons astrocytes, mouse cerebral endothelial cell (CECs) line vitro. The levels ROS generation, NADPH oxidase...
Osteoporosis is a progressive skeletal disease characterized by reduced bone density leading to fragility and an elevated risk of fractures. In osteoporotic conditions, decrease in happens due the augmented osteoclastic activity number osteoblast progenitor cells (mesenchymal stem cells, MSCs). We investigated new method cell therapy with membrane-engineered MSCs restore pool inhibit fractured bones. The primary active sites polymer are N-hydroxysuccinimide bisphosphonate groups that allow...
Part II presents the results which show that HA coatings significantly enhance MSC proliferation by 13% compared to titanium alloy base, while also exhibit an 11% increase. Porosity inversely affects CP-Ti’s elasticity. Coatings with lower porosity demonstrate better corrosion resistance. promote osteogenic activity and angiogenesis, is crucial for implant integration.
Introduction: Cardioplegic cardiac arrest with subsequent ischemic-reperfusion injuries can lead to the development of inflammation myocardium, leucocyte activation, and release enzymes. Flow reduction bronchial arteries, causing low-flow lung ischemia, leads a pulmonary regional inflammatory response. Hypoventilation during cardiopulmonary bypass (CPB) is responsible for microatelectasis, hydrostatic edema, poor compliance, higher incidence infection. Based on these facts, prevention...
Adult extracorporeal carbon dioxide removal (ECCO2R) systems and pediatric ECMO share the common objectives of having a low blood flow rate priming volume while safely maintaining sufficient respiratory support. The Hemolung is highly simplified adult ECCO2R system intended for partial support in patients with acute hypercapnic failure. objective this work was to conduct pre-clinical feasibility studies determine if efficient, active-mixing, can be translated population.14 healthy nonsedated...
Abstract Background Recent studies strongly suggest that gut microbiome is capable of influencing brain functions and contribute to the development Alzheimer’s disease (AD). However, only few have characterized human communities associated with AD. Moreover, reported changes in microbiomes AD patients from different countries are not similar. Therefore, more research needed order reveal relationships existing between ethnic populations. Here, we report first pilot case‐control study...
Alzheimer's disease is a chronic, incurable neurodegenerative and the most common form of age-related dementia. The on-set this among elderly population influenced by various factors such as lifestyle, stress levels, genetic predisposition, chronic diseases, environmental factors. Intestinal microbiome one affecting human health increasingly attracting attention scientists over past 15 years. microbiomes are community microorganisms that colonize gastrointestinal tract have huge impact on...
To our knowledge, no population-based studies have been conducted on dementia in Kazakhstan yet. The aim of pilot research was evaluation the risk factors Alzheimer’s disease and vascular Kazakhstani settings. 79 patients (37 males 42 females) 121 healthy controls (50 71 were included study. Among cases 45 (57%) had dementia, 34 (43%) dementia. Dementia varied age from 50 to 85 years, with a mean 67.5 ± SD 8.3 years. There (53%) females 37 (47%) males. A logistic regression analysis employed...
Abstract Background Chronic peripheral inflammation is one of the critical factors contributing significantly to development and progression Alzheimer’s disease (AD). Human animal studies strongly suggest that systemic inflammation, marked by changes in profile blood immune cells levels circulating pro‐inflammatory anti‐inflammatory cytokines, can promote or even precede conditions CNS. It has been reported cytokines are increased while decreased AD patients. However, despite increasing data...
Aim . The main purpose of this work is to evaluate the Hemolung pumping ability and gas exchange effectiveness while using catheters smaller diameter blood fl ow rates, applied in pediatrics. Material methods bench testing device with pediatric has been performed. bovine carboxymethylcellulose water solution were used as a model. operation data, analysis hydrodynamic pressure data collected. Results. pump curve results show that at maximum rotation rate was able achieve rates substantially...
Introduction. Fetal cell transplantation is a promising biomedical approach for disease treatment; however, the use of fetal therapy still experimental. This research was deemed necessity to provide evidence-based application as treatment method. The aim this study evaluate effect nerve in rat survivors (and non-survivors) after clinical death by mechanical asphyxia.Methods. 68 white laboratory rats were divided into two groups identical age and sex: control group 12-month adult male (n =...