A5066540105- Mechanical Circulatory Support Devices
- Respiratory Support and Mechanisms
- Cardiac Arrest and Resuscitation
- Inhalation and Respiratory Drug Delivery
- Hemoglobin structure and function
- Neonatal Respiratory Health Research
- Sepsis Diagnosis and Treatment
- Electrospun Nanofibers in Biomedical Applications
- Fuel Cells and Related Materials
- Membrane Separation and Gas Transport
- Membrane Separation Technologies
- Blood groups and transfusion
- Immune Response and Inflammation
- Complement system in diseases
- Transplantation: Methods and Outcomes
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Microfluidic and Capillary Electrophoresis Applications
- Aerosol Filtration and Electrostatic Precipitation
- Renal function and acid-base balance
- Pancreatic function and diabetes
- Cardiac Structural Anomalies and Repair
- Renal Transplantation Outcomes and Treatments
- Blood properties and coagulation
- Xenotransplantation and immune response
- 3D Printing in Biomedical Research
McGowan Institute for Regenerative Medicine
2013-2023
University of Pittsburgh
2013-2023
University of Pittsburgh Medical Center
2012-2022
University of Petroleum
2016
American College of Chest Physicians
2011
United States Army
2011
Institute of Chemical Engineering
2002-2010
United States Army Institute of Surgical Research
2008-2009
Southeast University
2003
Bioengineering Center
2002
S troke continues to be a significant cause of morbidity and mortality in the United States.Approximately 700 000 Americans have new or recurrent stroke each year, remains third leading death States when considered independently from other cardiovascular diseases.Stroke also serious, long-term disability States. 1 Major advances been made during past several decades prevention, treatment, rehabilitation.Despite successes delivering effective therapies, obstacles remain ensuring that...
Mechanical ventilation is injurious to the lung. Use of lung-protective strategies may complicate patient management, motivating a search for better lung-replacement approaches. We investigated ability novel extracorporeal venovenous CO2 removal device reduce minute while maintaining normocarbia.Prospective animal study.Government laboratory intensive care unit.Seven sedated swine.Tracheostomy, volume-controlled mechanical ventilation, and 72 hrs round-the-clock unit care. A 15-F dual-lumen...
Abstract Introduction Prior work suggests that leukocyte trafficking is determined by local chemokine gradients between the nidus of infection and plasma. We recently demonstrated therapeutic apheresis can alter immune mediator concentrations in plasma, protect against organ injury, improve survival. Here we aimed to determine whether removal chemokines from plasma experimental peritonitis changes subsequently enhances localization into infected compartment, away healthy tissues. Methods In...
Hollow fiber membranes (HFMs) used in artificial lungs (oxygenators) undergo plasma leakage (or wetting) which blood slowly fills the pores of wall, leaks into gas pathways, and overall exchange decreases. To overcome this problem resistant fibers are being developed that skinned asymmetric or composite symmetric versions microporous oxygenator fibers. This report evaluates several candidate HFMs terms their permeance resistance as measured a surfactant wet out test. Five were compared with...
A broadly applicable model for predicting controlled release could eliminate the need exploratory, in vitro experiments during design of new biodegradable matrix-based therapeutics. We have developed a simple mathematical that can predict many different types agents from bulk eroding polymer matrices without regression. New methods deterministically calculating magnitude initial burst and duration lag phase (time before Fickian release) were to enable model's broad applicability. To complete...
Improper compartmentalization of the inflammatory response leads to systemic inflammation in sepsis. Hemoadsorption (HA) is an emerging approach modulate sepsis-induced inflammation. We sought define effects HA on Escherichia coli-induced fibrin peritonitis rats. Hypothesis: both reprograms and recompartmentalizes Sprague Dawley male rats were subjected E. coli and, after 24 h, randomized or sham treatment (sepsis alone). Venous blood samples collected at 0, 1, 3 6 h (that is, 24–30 total...
For patients experiencing acute respiratory failure due to a severe exacerbation of chronic obstructive pulmonary disease (COPD), noninvasive positive pressure ventilation has been shown significantly reduce mortality and hospital length stay compared support with invasive mechanical ventilation. Despite continued improvements in the administration (NIV), refractory hypercapnia hypercapnic acidosis continue prevent its successful use many patients. Recent advances extracorporeal gas exchange...
Respiratory assist devices seek optimized performance in terms of gas transfer efficiency and thromboresistance to minimize device size reduce complications associated with inadequate blood biocompatibility. The exchange occurs at the surface hollow fiber membranes (HFMs) used these devices. In this study, three zwitterionic macromolecules were attached HFM surfaces putatively improve thromboresistance: (1) carboxyl-functionalized phosphorylcholine (PC) (2) sulfobetaine (SB) (mPC or...
The objective of this study was to demonstrate the safety and performance a unique extracorporeal carbon dioxide removal system (Hemolung, ALung Technologies, Pittsburgh, PA) which incorporates active mixing improve gas exchange efficiency, reduce exposure blood circuit, provide partial respiratory support at dialysis-like settings. An animal conducted using eight domestic crossbred sheep, 6–18 months age 49–115 kg in weight. sheep were sedated intubated, 15.5-Fr dual lumen catheter inserted...
Promising preclinical results have been obtained with blood purification therapies as adjuvant treatment for sepsis. However, the mechanisms by which these exert beneficial effects remain unclear. Some investigators suggested that removal of activated leukocytes from circulation might help ameliorate remote organ injury. We designed an extracorporeal hemoadsorption device capable capturing both cytokines and in order to test hypothesis leukocyte capture would alter circulating cytokine...