Native oxide surfaces of stainless steel 316L and Nitinol alloys their constituent metal oxides, namely nickel, chromium, molybdenum, manganese, iron, titanium, were modified with long chain organic acids to better understand film formation. The adhesion stability films octadecylphosphonic acid, octadecylhydroxamic octadecylcarboxylic octadecylsulfonic acid on these substrates examined in this study. formed analyzed by diffuse reflectance infrared Fourier transform spectroscopy, contact...

Crystal structures for the commercial monohydrate form and an anhydrate of dasatinib, oral anticancer agent, are presented along with characterization by Raman spectroscopy, powder X-ray diffraction, differential scanning calorimetry, thermogravimetric analysis. Solubility measurements conducted in water reveal that has dramatically improved solubility compared to hydrate form. Finally, dasatinib is a rare example promiscuous solvate former, basis this behavior can now be understood...

Shape memory alloys such as nitinol (NiTi) have gained interest due to their unique and unusual properties of thermal shape memory, superelasticity, good damping properties. Nitinol is mainly used for medical purposes. In order control the surface this alloy, self-assembled monolayers (SAMs) were formed characterized on native oxide first time. Factors which affect formation SAMs, head group functionality, chain length, tail varied analyzed. Functionalized alkyl phosphonic acid molecules...

In this study, perfluorinated phosphonic acid modifications were utilized to modify zinc oxide (ZnO) nanoparticles because they create a more stable surface due the electronegativity of perfluoro head group. Specifically, 12-pentafluorophenoxydodecylphosphonic acid, 2,3,4,5,6-pentafluorobenzylphosphonic and (1H,1H,2H,2H-perfluorododecyl)phosphonic have been used form thin films on nanoparticle surfaces. The modified then characterized using infrared spectroscopy, X-ray photoelectron...

The principal components of the 13C chemical shift tensors for ten crystallographically distinct carbon atoms active pharmaceutical ingredient cimetidine Form A have been measured using FIREMAT technique. Density functional theory (DFT) calculations and 15N magnetic shielding are used to assign peaks. DFT were performed on a training set organic crystals both plane-wave cluster-based approaches. former allowed several structural refinement strategies be employed, including utilizing...

Abstract Cannabidiol (CBD) vape pen usage has been on the rise given changing political and scientific climate as well promotion of these delivery systems a more accessible lower‐risk option for consumers. Despite being marketed safer way to use cannabis, CBD liquids are sold without restrictions or meticulous quality control procedures such toxicological clinical assessment, standards product preservation, investigative degradation analyses. Nine CBD‐labeled liquid samples purchased...

An assignment incorporating posters into a second-year analytical chemistry lab is described. Students work in groups and are assigned one of the application-themed weekly laboratories as topic. Course data acquired for these compiled spreadsheets that poster group then analyzes to present an on-campus session. Visual design with use minimal text emphasized, statistical analysis spreadsheet usage incorporated. This provides majority students course their first experience. By making revisit...

A surface-initiated polymerization of styrene on carboxylic acid terminated phosphonic monolayers was utilized to increase the corrosion resistance nitinol and nickel oxide surfaces. Alkyl chain ordering, organic reactions, wettability, film quality polymers were determined by infrared spectroscopy, atomic force microscopy, matrix-assisted laser desorption ionization spectrometry, water contact angles. The polystyrene proved be a better barrier than analysis with cyclic voltammetry...

Cannabis consumer products are a $4.6 billion industry in the U.S. that is projected to exceed $14 by 2025. Despite an absence of Food and Drug Administration (FDA) regulation or clinical data, thousands nutraceuticals, topical products, beauty claim benefits hemp cannabidiol. However, lack required quality control measures prevents consumers from knowing true concentration purities cannabis-labeled products. Thirteen over-the-counter were examined for presence cannabidiol (CBD), cannabinol...

Abstract Analysis and confirmation of monolayer film thickness on metal oxide surfaces has proven to be challenging. XPS AFM have been used investigate the formation. However, these techniques are difficult access and/or determine composition organic molecules surfaces. Here we demonstrate ability MALDI‐TOF characterize long alkyl chain phosphonic acid in thin films titanium, iron stainless steel. These systems known stable, strongly adhered films. The were characterized by IR, AFM, contact...

A series of undergraduate laboratory experiments that utilize reversed-phase HPLC separation, inductively coupled plasma spectroscopy (ICP), and scanning electron microscopy with energy dispersive (SEM-EDS) are described for the analysis commercial sunscreens. The active ingredients many sunscreen brands include zinc or titanium oxide in addition to organic acids. Students determine content using ICP, chemical composition as well particle sizes SEM-EDS. UV absorbers octocrylene oxybenzone...

Recently, topical products advertising cannabinoid ingredients have gained popularity. Consumers are seeing an increase of commercial containing from hemp oil to cannabidiol (CBD) due health benefit claims. Cosmetic cannabinoids currently not regulated at the federal level. A laboratory experiment for undergraduate students in analytical and organic chemistry courses was developed utilizing high-performance liquid chromatography (HPLC) analysis identify quantify compounds present...

The challenges facing metallic implants for reconstructive surgery include the leaching of toxic metal ions, a mismatch in elastic modulus between implant and treated tissue, risk infection. These problems can be addressed by passivating surface with an organic substrate incorporating antibiotic molecules. Nitinol (NiTi), nickel-titanium alloy, is used devices biomedical applications due to its shape memory superelasticity. However, unmodified NiTi carries localized nickel toxicity...

High-resolution solid-state NMR (SSNMR) spectroscopy has many advantages as a tool to characterize solid-phase material that finds applications in polymer chemistry, nanotechnology, materials science, biomolecular structure determination, and others, including the pharmaceutical industry. The technology associated with achieving high resolution evolved where SSNMR become routine. To highlight capability, an experiment exploring polymorphism compound is described. Polymorphism can be studied...

Melanoma, a type of cancer that develops in melanocytes, is usually caused by direct exposure skin to ultraviolet (UV) radiation resulting cellular damage. In this study, procedure determine the effects various commercial sunscreens with SPF values ranging from 15 100 was developed using pig mimic human skin. These contain inorganic filters, such as zinc oxide and titanium dioxide; active organic ingredients, octocrylene oxybenzone; or both. As model for skin, analyzed before after UV...

With the advancements in broad-spectrum sunscreens and recent bans on benzene-based due to their environmental toxicity, there has been a push toward containing inorganic active ingredients. In this study, procedure was developed analyze particle size distribution of ingredients, titanium dioxide (TiO2) and/or zinc oxide (ZnO), with sun protection factor (SPF) values ranging from 15 50 using dynamic light scattering (DLS). These components are often engineered as nanoparticles order reduce...