A5071706443- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Hearing, Cochlea, Tinnitus, Genetics
- Ear Surgery and Otitis Media
- Cancer-related molecular mechanisms research
- Biochemical Analysis and Sensing Techniques
- Acute Myeloid Leukemia Research
- Lung Cancer Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
- Autophagy in Disease and Therapy
- Inflammasome and immune disorders
- Cytokine Signaling Pathways and Interactions
- Cancer Genomics and Diagnostics
- Cancer-related gene regulation
- Head and Neck Cancer Studies
- Single-cell and spatial transcriptomics
- Gene expression and cancer classification
- Vestibular and auditory disorders
- Epigenetics and DNA Methylation
- Genetic factors in colorectal cancer
- Sensory Analysis and Statistical Methods
- Cancer Mechanisms and Therapy
Medical University of South Carolina
2023-2024
Indiana University – Purdue University Indianapolis
2020-2023
Jiujiang University
2019-2023
Wuhan Institute of Technology
2023
Indiana University School of Medicine
2021
Huazhong University of Science and Technology
2014-2019
Life University
2019
Acute myeloid leukemia (AML) is one of the most common hematopoietic malignancies that has an unfavorable outcome and a high rate relapse. Autophagy plays vital role in development therapeutic responses to leukemia. This study identifies potential autophagy-related signature monitor prognoses patients AML. Transcriptomic profiles AML (GSE37642) with relevant clinical information were downloaded from Gene Expression Omnibus (GEO) as training set while TCGA-AML GSE12417 used validation...
Lung squamous cell carcinoma (LSCC) is the most common subtype of non-small lung cancer. Immunotherapy has become an effective treatment in recent years, while patients showed different responses to current treatment. It vital identify potential immunogenomic signatures predict patient' prognosis. The expression profiles LSCC with clinical information were downloaded from TCGA database. Differentially expressed immune-related genes (IRGs) extracted using edgeR algorithm, and functional...
The tumor microenvironment (TME) has a strong influence on the progression, therapeutic response, and clinical outcome of acute myeloid leukemia (AML), one most common hematopoietic malignancies in adults. In this study, we identified TME-related genes associated with AML prognosis. Gene expression profiles from patients were downloaded TCGA database, immune stromal scores calculated using ESTIMATE algorithm. Immune correlated features such as FAB subtypes patient's age. After categorizing...
Almost one third of the three million people in China suffering severe deafness are children, and 50% these cases believed to have genetic components their etiology. Newborn hearing screening can complement Universal Neonatal Hearing Screening for diagnosis congenital loss as well identifying children at risk late-onset progressive impairment. The aim this joint academic Ministry Health project was prototype a cost effective newborn screen community health setting on city-wide level,...
Our ability to taste bitterness affects our food choices and alcohol consumption.
Background Aberrant fatty acid metabolism (FAM) plays a critical role in the tumorigenesis of human malignancies. However, studies on its impact lung adenocarcinoma (LUAD) are limited. Methods We developed prognostic signature comprising 10 FAM-related genes (GPR115, SOAT2, CDH17, MOGAT2, COL11A1, TCN1, LGR5, SLC34A2, RHOV, and DKK1) using data from LUAD patients The Cancer Genome Atlas (TCGA). This was validated six independent datasets Gene Expression Omnibus (GEO). Patients were...
The morphology of breast tumors is complicated and diagnosis can be difficult. We present here a novel diagnostic model which we validate on both array-based RNA sequencing platforms reliably distinguishes this tumor type across multiple cohorts. also examine how molecular classification predicts sensitivity to common chemotherapeutics in cell-line based assays. A total 1845 invasive cancer cases six cohorts were collected, split into discovery validation cohorts, classifier was created...
Head and neck squamous cell carcinoma (HNSCC) represents one of the most prevalent malignant tumors epithelial origins with unfavorable outcomes. Increasing evidence has shown that dysregulated long non-coding RNAs (lncRNAs) correlate tumorigenesis genomic instability (GI), while roles GI-related lncRNAs in tumor immune microenvironment (TIME) predicting cancer therapy are still yet to be clarified. In this study, transcriptome somatic mutation profiles clinical parameters were obtained from...
Introduction: Non-Small-Cell Lung Cancer (NSCLC) represents the leading cause of cancer deaths in world. We previously found that daidzein, one key bioactivators soy isoflavone, can inhibit NSCLC cell proliferation and migration, while molecular mechanisms daidzein remain unclear. Methods: developed an nude mouse model using H1299 cells treated mice with (30 mg/kg/day). Mass spectrometry analysis tumor tissues from daidzein-treated identified 601 differentially expressed proteins (DEPs)...
Purpose: To investigate the expression and prognosis of inhibitor DNA-binding (ID) protein family in non-small cell lung cancer (NSCLC). Methods: The mRNA prognostic relevance ID using Oncomine, UALCAN, Kaplan-Meier plot, Cancer Genome Atlas (TCGA) databases were compiled analyzed. Also, associations between individual IDs' clinicopathological features NSCLC patients identified unpaired t-test. Results: There was significantly higher each normal cells compared to tissues, including...
Abstract Background Understanding the role of STAT family in gastric cancer (GC) is essential for developing targeted therapies and improving patient outcomes. However, comprehensive analysis expression its prognostic significance GC limited. This study aims to address this gap by examining normal tissues evaluating value across clinical subgroups. Methods mRNA levels were compared between tumor using fold change analysis. Kaplan–Meier curves assessed correlation outcomes, with statistical...
To investigate the screening results and compliance of low-dose computed tomography (LDCT) among high-risk lung cancer populations in Jiangxi Province from 2018 to 2020, explore related influencing factors compliance.
Abstract Background: Lung adenocarcinoma (LUAD) is the most common and aggressive subtype of non-small cell lung cancer. Aberrant fatty acid metabolism (FAM) has been demonstrated to play an essential role in tumorigenesis human cancers, yet limited studies LUAD. Methods: The RNA-sequencing dataset LUAD patients with clinical features from TCGA database was used as training set. Six independent cohorts totaling 1,368 encompassing diverse platforms GEO were employed validation sets....