A5047525396- Smoking Behavior and Cessation
- Pharmacogenetics and Drug Metabolism
- RNA Research and Splicing
- Genomics and Chromatin Dynamics
- Nicotinic Acetylcholine Receptors Study
- Genetic Associations and Epidemiology
- RNA Interference and Gene Delivery
- Receptor Mechanisms and Signaling
- Developmental Biology and Gene Regulation
- Computational Drug Discovery Methods
- Alcohol Consumption and Health Effects
- HIV Research and Treatment
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Hearing, Cochlea, Tinnitus, Genetics
- Asthma and respiratory diseases
- Ear Surgery and Otitis Media
- Gene expression and cancer classification
- Metabolism and Genetic Disorders
- Geriatric Care and Nursing Homes
- Hereditary Neurological Disorders
- Chromatin Remodeling and Cancer
- Signaling Pathways in Disease
- Machine Learning in Bioinformatics
- Exercise and Physiological Responses
Stanford University
1997-2025
Huazhong University of Science and Technology
2013-2019
Life University
2019
SRI International
2003-2010
Oklahoma State University Center for Health Sciences
2007
University of California, San Francisco
2005-2006
Oregon Research Institute
2005
City Of Hope National Medical Center
2005
Menlo School
2004
Incyte (United States)
2002
Using the technique of differential cDNA library screening, a clone was isolated from an estrogen receptor (ER)-positive breast carcinoma cell line (MCF7) based upon overexpression this gene compared to ER-negative (MDA-MB-231). Sequence analysis determined that it shared significant homology G-protein-coupled receptors. This receptor, GPCR-Br, abundantly expressed in ER-positive lines MCF7, T-47D, and MDA-MB-361. Expression absent or minimal BT-20, MDA-MB-231, HBL-100. GPCR-Br ubiquitously...
Fas is a surface receptor that can transmit signals for apoptosis. Using retroviral cDNA library–based functional cloning we identified gene toso, blocks Fas-mediated Toso expression was confined to lymphoid cells and enhanced after cell-specific activation processes in T cells. appeared limited inhibition of apoptosis mediated by members the TNF family capable inhibiting cell self-killing induced TCR up-regulate ligand. We mapped effect caspase-8 processing, most upstream caspase activity...
Here we describe two mammalian transcription factors selectively expressed in the central nervous system. Both proteins, neuronal PAS domain protein (NPAS) 1 and NPAS2, are members of basic helix-loop-helix-PAS family factors. cDNAs encoding mouse human forms NPAS1 NPAS2 have been isolated sequenced. RNA blotting assays demonstrated selective presence mRNAs brain spinal cord tissues adult mice. mRNA was first detected at embryonic day 15 development, shortly after early organogenesis brain....
Plasma sex hormone concentrations have been used as biomarkers in epidemiological studies of many conditions including cancer, obesity, bone density, and coronary heart disease. The objective this analysis was to estimate genetic nongenetic influences on endogenous hormones (testosterone, estradiol, estrone, SHBG) a large sample 532 adult white male twins (134 monozygotic 132 dizygotic twin pairs) from the National Heart, Lung, Blood Institute Twin Study. Participants were aged 59-70 yr at...
B52, also called SRp55, is a 52-kDa member of the Drosophila SR protein family general splicing factors. Escherichia coli-produced B52 capable both activating and affecting alternative splice site choice in human vitro reactions. Here we report isolation null mutant generated by remobilizing P element residing near gene. The resulting deletion, B52(28), confined to gene its neighbor Hrb87F Second-instar larvae homozygous for deletion are deficient mRNA protein. lethal at first- second-instar...
CD5 and CD6, two type I cell surface antigens predominantly expressed by T cells a subset of B cells, have been shown to function as accessory molecules capable modulating activation. Here we report the cloning cDNA encoding Spalpha, secreted protein that is highly homologous CD6. Spalpha has same domain organization extracellular region CD6 composed three SRCR (scavenger receptor cysteine rich) domains. Chromosomal mapping fluorescence in situ hybridization radiation hybrid panel analysis...
Abstract Genome‐wide model free linkage analysis was conducted for nicotine dependence and tobacco use phenotypes in 607 members of 158 nuclear families consisting at least two ever smokers (100 or more cigarettes smoked lifetime). DNA from whole blood genotyped 739 autosomal microsatellite polymorphisms with an average inter‐marker distance 4.6 cM. A peak LOD score 2.7 observed on chromosome 6 scores the Fagerström Test Nicotine Dependence. Exploratory analyses were to determine whether...
Understanding the dynamic tumor immune microenvironment (TIME) is important in guiding immunotherapy. We have previously validated signatures predictive of checkpoint inhibitor efficacy which distinguish immunomodulatory, mesenchymal stem-like, and phenotypes. Here we use twenty types (7162 samples) to identify potentially conserved biology within these TIME spaces, genes co-expressed across distinct cell involved processes, association with ICI response. One signature, contained multiple...
To determine the relationship between joint variation in 2 dopaminergic genes and likelihood of nonsmoking following treatment with bupropion sustained release (SR).Three hundred twenty-three participants a SR smoking cessation effectiveness trial 12-month follow-up were genotyped for variants dopamine receptor gene DRD2 transporter SLC6A3.Self-reported 7-day point prevalence nonsmoking.Neither genotype alone was associated point-prevalent at follow-up. However, presence A1 allele, SLC6A3...
Almost one third of the three million people in China suffering severe deafness are children, and 50% these cases believed to have genetic components their etiology. Newborn hearing screening can complement Universal Neonatal Hearing Screening for diagnosis congenital loss as well identifying children at risk late-onset progressive impairment. The aim this joint academic Ministry Health project was prototype a cost effective newborn screen community health setting on city-wide level,...
B52, also called SRp55, is a 52-kDa member of the Drosophila SR protein family general splicing factors. Escherichia coli-produced B52 capable both activating and affecting alternative splice site choice in human vitro reactions. Here we report isolation null mutant generated by remobilizing P element residing near gene. The resulting deletion, B52(28), confined to gene its neighbor Hrb87F Second-instar larvae homozygous for deletion are deficient mRNA protein. lethal at first- second-instar...
CYP2A6 is the major enzyme involved in nicotine metabolism, yet large interindividual variations rate of metabolism exist within groups individuals having same genotype. We investigated influence genetic variation another potential nicotine-metabolizing enzyme, CYP2B6, and its interaction with CYP2A6, on nicotine.Two hundred twelve healthy Caucasian adult twin volunteers underwent an intravenous infusion stable isotope-labeled metabolite, cotinine, for characterization pharmacokinetic...
The SWI/SNF-related, matrix-associated, actin-dependent regulators of chromatin (SMARC), also called BRG1-associated factors, are components human SWI/SNF-like chromatin-remodeling protein complexes. We mapped five SMARC genes toregions on four different chromosomes,SMARCC1to 3p23–p21,SMARCC2to 12q13–q14,SMARCD1to 12q13–q14,SMARCD2to 17q23–q24, andSMARCD3to 7q35–q36.SMARCC1,SMARCC2,andSMARCD1are assigned to chromosomal regions that frequently involved in somatic rearrangements...
HIV/AIDS has the highest mortality among infectious diseases in China. In ongoing efforts to alleviate this crisis, national government placed great emphasis on Henan province where HIV-infected former plasma donors 1990s contributed AIDS becoming a public health crisis. Concomitant with initiative focusing use of phamacogenetics for better prediction treatment response, we studied genetic variants known pharmacokinetic phenotypes set 298 HAART-treated (highly active antiretroviral therapy)...
Fatty-acid amide hydrolase (FAAH) is a membrane-bound enzyme that degrades neuromodulatory fatty acid amides, such as oleamide and anandamide, expressed in the mammalian central nervous system. To evaluateFAAHgenes candidates for neurogenetic diseases humans mice, we have mapped loci both species determined their intron–exon structures. The humanFAAHgene was to region 1p34–p35, closely linked D1S197 D1S443, by using PCR analysis of somatic cell hybrid (SCH) radiation mapping panels. Analysis...
Our ability to taste bitterness affects our food choices and alcohol consumption.
The COVID-19 pandemic highlighted the need for advance care planning (ACP) as a way to help mitigate various concerns that accompanied healthcare crisis. However, unique obstacles typical ACP practice necessitated guidance and innovation facilitate these vital conversations. aim of this systematic review was identify barriers facilitators arose during determine how affected across different contexts among populations. This (PROSPERO registration number: CRD42022359092), which adheres PRISMA...