Iron oxide has been developed as either T1 or T2 magnetic resonance imaging (MRI) contrast agents by controlling the size and composition; however, underlying mechanism of contrasts in one iron entity is still not well understood. Herein, we report that freestanding superparamagnetic magnetite nanoplates with (111) exposed facets have significant but interactional effects. We demonstrate main contribution chemical exchange on iron-rich Fe3O4(111) surfaces, whereas relaxation dominated...

In this paper, we demonstrate the tunable T1 and T2 contrast abilities of engineered iron oxide nanoparticles with high performance for liver contrast-enhanced magnetic resonance imaging (MRI) in mice. To enhance diagnostic accuracy MRI, large numbers agents or ability have been widely explored. The comprehensive investigation high-performance MRI controllable is importance field molecular imaging. study, synthesized uniform manganese-doped (MnIO) size from 5 to 12 nm comprehensively...

Magnetic resonance angiography using gadolinium-based molecular contrast agents suffers from short diagnostic window, relatively low resolution and risk of toxicity. Taking into account the chemical exchange between metal centers surrounding protons, magnetic nanoparticles with suitable surface interfacial features may serve as alternative T1 agents. Herein, we report engineering on structure iron oxide nanoplates to boost ability through synergistic effects exposed metal-rich Fe3O4(100)...

Delivery of arsenic trioxide (ATO), a clinical anticancer drug, has drawn much attention to improve its pharmacokinetics and bioavailability for efficient cancer therapy. Real-time in situ monitoring ATO behaviors vivo is highly desirable tumor treatment. Herein, we report an ATO-based multifunctional drug delivery system that efficiently delivers treat tumors allows real-time release by activatable T1 imaging. We loaded water-insoluble manganese arsenite complexes, the prodrug, into hollow...

The efficacy of chemodynamic therapy (CDT) and its potential to induce immunogenic cell death (ICD) are highly dependent on the types efficiency generated reactive oxygen species (ROS). Herein, we innovatively develop a manganese platinum (MnPt) nanozyme with dual ROS generation for magnetic resonance imaging guided CDT ICD. multivalence state Mn ions authorizes MnPt simultaneously generate hydroxyl radical singlet under high H2O2 acid condition, which obviously increases ROS. Significantly,...

Traditional magnetic resonance imaging (MRI) contrast agents (CAs) are a type of "always on" system that accelerates proton relaxation regardless their enrichment region. This feature leads to decrease in signal differences between lesions and normal tissues, hampering applications accurate early diagnosis. Herein, we report strategy fabricate glutathione (GSH)-responsive one-dimensional (1-D) manganese oxide nanoparticles (MONPs) with improved T2 relaxivities achieve effective T2/T1...

We described the smart and targeted magnetic nanocarriers to control delivery release of anticancer drug doxorubicin (DOX) in vitro demonstrated that they can exhibit much higher cytotoxicity cancer cells than free DOX. The conjugation magnetite nanoparticles (∼14 nm diameter) DOX molecule via acid-labile imine bond endows with three advanced features: magnetically controllable, specific targeting, pH-responsive. cell toxicity assays indicated pH-sensitive (IC50 0.13 μg mL−1 HeLa cells) have...

We combined silver and iron oxide nanoparticles to make unique Ag@Fe2O3 yolk–shell multifunctional by the Kirkendall effect. After surface functionalization using glucose, Ag@Fe2O3–Glu conjugates exhibited both high capture efficiency of bacteria potent antibacterial activity. The nanostructures may offer a platform for simultaneous rapid detection safe detoxification treatment.

Investigating the surface structure, including crystal and surface‐coating ligands, of nanoparticulate T 1 contrast agent may help to understand relaxation enhancement in vitro vivo. This study presents a novel strategy develop high‐performance magnetic resonance imaging (MRI) agents through optimizing nanocrystal nanobio interface. Based on optimized surface, manganese oxide nanocubes (MOCs) show significantly higher surface‐to‐volume ratio an approximately threefold r value compared...

High-performance magnetic resonance imaging (MRI) contrast agents and novel enhancement strategies are urgently needed for sensitive accurate diagnosis. Here we report a strategy to construct new T1 agent based on the Solomon–Bloembergen–Morgan (SBM) theory. We loaded ultrasmall gadolinium oxide nanoparticles into worm-like interior channels of mesoporous silica nanospheres (Gd2O3@MSN nanocomposites). This unique structure endows nanocomposites with geometrical confinement, high molecular...

Recently, some types of MnO nanoparticle (Mn-NP) with favorable imaging capacity have been developed to improve the biocompatible profile existing Mn-based MRI contrast agent Mn-DPDP; however, overall bio-effects and potential toxicity remain largely unknown. In this study, 1H NMR-based metabolic profiling, integrated traditional biochemical analysis histopathological examinations, was used investigate absorption, distribution, metabolism, excretion Mn-NPs as candidates for agent. The...

Tyrosinase is an important marker of human diseases such as the neurodegeneration associated with Parkinson's disease and melanoma. Sensitive detection tyrosinase activity in vitro inside cells great significance to medical diagnostics skin disorder treatments. With unique photophysical properties, semiconductor quantum dots (QDs) are employed photoluminescent platforms for various biosensing, particular enzyme activities. In this work, QDs functionalized tyrosine zwitterionic molecules...

Cation exchange is a powerful means to adjust the properties of nanocrystals through composition change with morphology retention. Herein, we demonstrate that cation can engineer iron oxide dramatically improve their contrast ability in magnetic resonance imaging (MRI). We successfully construct manganese and zinc engineered nanoparticles diverse shapes (sphere, cube, octapod) by facile reactions. Extended X-ray absorption fine structure (EXAFS) study indicates Mn2+ Zn2+ ions are doped into...

The ability to encapsulate and manipulate droplets with a picoliter volume of samples reagents shows great potential for practical applications in chemistry, biology, materials science. Magnetic control is promising approach droplet manipulation due its wireless ease implementation. However, it challenged by the poor biocompatibility magnetic aqueous droplets. Moreover, current technology problematic because molecule leakage between In paper, we propose multifunctional surface coated layer...

Glutathione (GSH) capped CdTe semiconductor quantum dots (QDs) are applied for detecting mercuric ions (Hg2+) of trace quantity. The synthesis GSH-capped (CdTe@GSH) QDs is cost-efficient and straightforward. We observed that Hg2+ can quantitatively quench the fluorescence CdTe@GSH further induce slight redshift emission peaks due to confinement effect. Detailed studies by spectroscopy, dynamic light scattering (DLS), electrospray ionization mass spectrometry (ESI-MS) demonstrated competitive...

We report a strategy to increase the<italic>T</italic>₁contrast ability of magnetite nanoparticles through substituting undesirable Fe(<sc>ii</sc>) ions with Mn(<sc>ii</sc>) on the surface nanoparticles.

Arsenic trioxide is a clinical drug that can be used to successfully treat acute promyelocytic leukemia. However, its therapeutic effect on solid tumors limited because of the poor pharmacokinetics and dose-limiting toxicity. Here, we report facile strategy achieve high anticancer activity arsenic by loading nanoparticulate prodrug into hollow silica inorganic nanoparticles. Because appropriate size, pH sensitivity, surface targeted modification, this smart nanosized system deliver cancer...